The General Approach to Cystic Fibrosis Pulmonary Infection in Russia

ABSTRACT Cystic fibrosis patients infected with strains from different genomovars of the Burkholderia cepacia complex can experience diverse clinical outcomes. To identify genomovar-specific determinants that might be responsible for these differences, we developed a pulmonary model of infection in BALB/c mice. Mice were rendered leukopenic by administration of cyclophosphamide prior to intranasal challenge with 1.6 × 104 bacteria. Five of six genomovar II strains persisted at stable numbers in the lungs until day 16 with minimal toxicity, whereas zero of seven genomovar III strains persisted but resulted in variable toxicity. We have developed a chronic pulmonary model of B. cepacia infection which reveals differences among genomovars in terms of clinical infection outcome.

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The future of antimicrobial therapy in the era of antibiotic resistance in cystic fibrosis pulmonary infection

Expert Review of Respiratory Medicine ◽

10.1586/17476348.2013.814411 ◽

2013 ◽

Vol 7 (4) ◽

pp. 385-396 ◽

Cited By ~ 10

Author(s):

G McCaughey ◽

DF Gilpin ◽

JS Elborn ◽

Michael M Tunney

Keyword(s):

Cystic Fibrosis ◽

Antibiotic Resistance ◽

Antimicrobial Therapy ◽

Pulmonary Infection ◽

The Future

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EPS4.02 Porphyromonas, a candidate biomarker for detection of Pseudomonas aeruginosa pulmonary infection in cystic fibrosis

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(18)30254-6 ◽

2018 ◽

Vol 17 ◽

pp. S43 ◽

Cited By ~ 1

Author(s):

C.-A. Guilloux ◽

G. Marenne ◽

S. Mondot ◽

C. Lamoureux ◽

L. Billard ◽

...

Keyword(s):

Cystic Fibrosis ◽

Pseudomonas Aeruginosa ◽

Pulmonary Infection

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Pulmonary Infection and its Management in Cystic Fibrosis Patients in the Czech Republic

Cystic Fibrosis Pulmonary Infections: Lessons from Around the World ◽

10.1007/978-3-0348-7359-8_21 ◽

1996 ◽

pp. 251-257 ◽

Cited By ~ 1

Author(s):

Věra Vávrová ◽

Zdenka Jedličková ◽

Otto Lochmann ◽

Dana Zemková ◽

Hana Krásničanová ◽

...

Keyword(s):

Cystic Fibrosis ◽

Czech Republic ◽

Pulmonary Infection ◽

The Czech Republic

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Multiple Microaerophilic Streptococcal Lung Abscesses After Orthodontic Treatment

PEDIATRICS ◽

10.1542/peds.70.5.722 ◽

1982 ◽

Vol 70 (5) ◽

pp. 722-724

Author(s):

Robert C. Stern ◽

Robert J. Berkowitz ◽

Susan B. Shurin ◽

Ricardo U. Sorensen ◽

John R. Haaga

Keyword(s):

Cystic Fibrosis ◽

Sickle Cell Anemia ◽

Supine Position ◽

Orthodontic Treatment ◽

Pulmonary Infection ◽

Neuromuscular Diseases ◽

Dental Cement ◽

Rubber Dam ◽

Rubber Dams ◽

Dental Work

An immunocompetent 12-year-old boy developed multiple microaerophilic streptococcal lung abscesses after application of orthodontic bands ("braces"). The dental work was done in the supine position. The data suggest that the patient aspirated the organisms and, possibly, flecks of dental cement, during orthodontic treatment. "Rubber dams" should be used to help prevent aspiration in children who receive dental work in the supine position. When a rubber dam cannot be used, as with orthodontic treatment, physicians should advise patients who are at risk for developing pulmonary infection (eg, patients with neuromuscular diseases which compromine cough and/or gag, cystic fibrosis, sickle cell anemia, primary immunodeficiency, etc) to have this dental work, including orthodontic treatment, performed in the erect position.

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72 Inhalatory antibiotic therapy in cystic fibrosis and emergence of colistin resistant Gram-negative non-fermenting bacteria: a new problem in pulmonary infection treatment?

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(14)60208-3 ◽

2014 ◽

Vol 13 ◽

pp. S64

Author(s):

P. Morelli ◽

E. Delfino ◽

R. Casciaro ◽

A. Formiga ◽

A. Pellettieri ◽

...

Keyword(s):

Cystic Fibrosis ◽

Antibiotic Therapy ◽

Pulmonary Infection ◽

Gram Negative ◽

Infection Treatment ◽

Fermenting Bacteria

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Pseudomonas aeruginosa bacteremia and prostatitis in a patient with cystic fibrosis

Canadian Urological Association Journal ◽

10.5489/cuaj.173 ◽

2013 ◽

Vol 7 (1-2) ◽

pp. 1

Author(s):

Anju Anand ◽

Elizabeth Tullis ◽

Anne Stephenson ◽

J. Curtis Nickel ◽

Michael J. Leveridge

Keyword(s):

Cystic Fibrosis ◽

Pseudomonas Aeruginosa ◽

Lower Urinary Tract ◽

Pulmonary Infection ◽

Respiratory Infections ◽

Bacterial Prostatitis ◽

Systemic Dissemination ◽

Microbial Etiology ◽

Acute Bacterial Prostatitis ◽

Lower Urinary

Patients with cystic fibrosis (CF) commonly suffer chronic respiratory infections, although systemic dissemination is relatively rare. Acute bacterial prostatitis presents dramatically and is believed to be mostly caused by local migration (with or without instrumentation) of the lower urinary tract and presents with a predictable microbial etiology. We report a case of a 26-year-old man presenting with acute Pseudomonas aeruginosa bacterial prostatitis due to hematogenous propagation from a chronic pulmonary infection.

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