The future of antimicrobial therapy in the era of antibiotic resistance in cystic fibrosis pulmonary infection

2013 ◽  
Vol 7 (4) ◽  
pp. 385-396 ◽  
Author(s):  
G McCaughey ◽  
DF Gilpin ◽  
JS Elborn ◽  
Michael M Tunney
Mycoses ◽  
2021 ◽  
Author(s):  
Mohanad Al‐Obaidi ◽  
Hamid Badali ◽  
Connie Cañete‐Gibas ◽  
Hoja P. Patterson ◽  
Nathan P. Wiederhold

1986 ◽  
Vol 75 (1) ◽  
pp. 128-138 ◽  
Author(s):  
U. B. SCHAAD ◽  
D. DESGRANDCHAMPS ◽  
R. KRAEMER

2002 ◽  
Vol 70 (5) ◽  
pp. 2715-2720 ◽  
Author(s):  
Karen K. Chu ◽  
Donald J. Davidson ◽  
T. Keith Halsey ◽  
Jacqueline W. Chung ◽  
David P. Speert

ABSTRACT Cystic fibrosis patients infected with strains from different genomovars of the Burkholderia cepacia complex can experience diverse clinical outcomes. To identify genomovar-specific determinants that might be responsible for these differences, we developed a pulmonary model of infection in BALB/c mice. Mice were rendered leukopenic by administration of cyclophosphamide prior to intranasal challenge with 1.6 × 104 bacteria. Five of six genomovar II strains persisted at stable numbers in the lungs until day 16 with minimal toxicity, whereas zero of seven genomovar III strains persisted but resulted in variable toxicity. We have developed a chronic pulmonary model of B. cepacia infection which reveals differences among genomovars in terms of clinical infection outcome.


PEDIATRICS ◽  
1967 ◽  
Vol 40 (2) ◽  
pp. 224-232
Author(s):  
Welton M. Gersony ◽  
George H. McCracken

Seven patients less than 2 years of age with purulent pericarditis were encountered. Four infants survived, including the first infant reported with meningococcal pericarditis. Including the present patients, 50 infants with suppurative pericarditis have been described in the literature. The overall mortality was 67%; it was 47% among patients in whom the diagnosis was made clinically. Staphylococcus aureus was the most common infecting organism, and it was responsible for the greatest number of deaths. Pulmonary infection was by far the most frequently observed associated illness, whereas purulent pericarditis occurring as a primary infection was rare. Survival from purulent pericarditis depends upon adequate pericardial drainage with antimicrobial therapy. Antibiotics alone have not been successful in the treatment of this disease.


2018 ◽  
Vol 17 ◽  
pp. S43 ◽  
Author(s):  
C.-A. Guilloux ◽  
G. Marenne ◽  
S. Mondot ◽  
C. Lamoureux ◽  
L. Billard ◽  
...  

Author(s):  
Věra Vávrová ◽  
Zdenka Jedličková ◽  
Otto Lochmann ◽  
Dana Zemková ◽  
Hana Krásničanová ◽  
...  

Author(s):  
Tatiana E. Guembitskaia ◽  
Ludmila A. Vishnyakova ◽  
Ludmila A. Zhelenina ◽  
Nikolai J. Kapranov

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