Performance Comparison of Screening Tests for POAG for T2DM Using Comp2ROC Package

Early Development of Drug-Induced Hepatic Necrosis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066942 ◽

1971 ◽

Vol 29 ◽

pp. 576-577

Author(s):

F. G. Zaki ◽

E. Detzi ◽

C. H. Keysser

Keyword(s):

Early Development ◽

Hepatic Necrosis ◽

Screening Tests ◽

Dense Matrix ◽

Sprague Dawley ◽

Electron Microscopic ◽

Drug Induced ◽

Hepatocellular Damage ◽

Sprague Dawley Rats ◽

Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

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A Validation Study of the Elementary and Advanced Screening Tests of the Clinical Evaluation of Language Functions (CELF)

Language Speech and Hearing Services in Schools ◽

10.1044/0161-1461.1404.215 ◽

1983 ◽

Vol 14 (4) ◽

pp. 215-222 ◽

Cited By ~ 3

Author(s):

Sol Ribner ◽

Laurence Becker ◽

Sid Marks ◽

Paul Kahn ◽

Fred Wolfson

Keyword(s):

Clinical Evaluation ◽

Validation Study ◽

Screening Tests ◽

Language Functions

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Biochemical screening tests. Effect of panel size on medical care

Archives of Internal Medicine ◽

10.1001/archinte.129.1.91 ◽

1972 ◽

Vol 129 (1) ◽

pp. 91-97 ◽

Cited By ~ 2

Author(s):

G. D. Friedman

Keyword(s):

Medical Care ◽

Screening Tests ◽

Biochemical Screening ◽

Panel Size

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Age of first diagnosis in children with cerebral palsy - the need for new developmental screening tests

Acta Paediatrica ◽

10.1080/080352598750013950 ◽

1998 ◽

Vol 87 (7) ◽

pp. 814-814

Author(s):

DI Zafeiriou ◽

IG Tsikoulas

Keyword(s):

Cerebral Palsy ◽

Developmental Screening ◽

Screening Tests ◽

Children With Cerebral Palsy ◽

First Diagnosis

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Kognition und Motorik

Therapeutische Umschau ◽

10.1024/0040-5930/a000668 ◽

2015 ◽

Vol 72 (4) ◽

pp. 219-224 ◽

Cited By ~ 2

Author(s):

Stephanie A. Bridenbaugh

Keyword(s):

Dual Task ◽

Screening Tests ◽

Kognitive Defizite ◽

Ältere Erwachsene

Es gibt eine starke Assoziation zwischen Kognition und Mobilität. Ältere Erwachsene mit Gangdefiziten haben ein erhöhtes Risiko, kognitive Defizite, sogar eine Demenz, zu entwickeln. Kognitive Defizite wiederum sind mit einer Verschlechterung des Gehens assoziiert. Sowohl kognitive als auch Mobilitätsdefizite sind mit einem erhöhten Sturzrisiko verbunden. Untersuchungen der Kognition, vor allem der Exekutivfunktionen, und die funktionale Mobilität sollen daher ein wesentlicher Bestandteil jedes umfassenden geriatrischen Assessments sein. Einige schnelle Screening-Tests können in der Hausarztpraxis durchgeführt werden, um Mobilitätsprobleme zu erfassen. Falls diese pathologisch ausfallen, sollten genauere Ganguntersuchungen veranlasst werden. Bei Untersuchungen des Ganges sind Dual-Task Paradigmen (Gehen und gleichzeitig eine andere Aufgaben ausführen) besonders aussagekräftig in der Früherkennung von Mobilitäts- und auch Hirnleistungsdefiziten. Die Früherkennung erlaubt eine frühzeitige Implementierung von gezielten Interventionen, um die Gangsicherheit und möglicherweise auch gewisse Hirnleistungen zu verbessern.

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