Anti-inflammatory Effect of Short Neck Clam (Tapes philippinarum) Water Extract Containing Taurine in Zebrafish Model

The root bark of Lycium barbarum (Lycii radicis cortex, LRC) is used as a cooling agent for fever and night sweats in East Asian traditional medicine. The inhibitory effect of LRC water extract on inflammation is unknown. In this study, the anti-inflammatory effect of LRC was investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage, RAW 264.7 cells. LRC extract significantly decreased the LPS-induced production of inflammatory mediators, nitric oxide (NO), prostaglandin (PG) E2 and pro-inflammatory cytokines, interleukin (IL)-1β and IL-6 in the cells. In addition, LRC extract inhibited the LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, and inflammatory cytokines mRNA in the cells. The action mechanism of LRC underlies the blocking of LPS-mediated p38 and Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPKs), and the nuclear factor (NF)-κB signaling pathway. These results indicate that LRC extract inhibits the inflammatory response in activated macrophages by down-regulating the transcription levels of inflammatory mediators and blocking the MAPKs and NF-κB pathway.

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Antioxidant Effects of Short-Neck Clam (Tapes philippinarum) Water Extract Containing Taurine Against AAPH-Induced Oxidative Stress in Zebrafish Embryos

Advances in Experimental Medicine and Biology - Taurine 10 ◽

10.1007/978-94-024-1079-2_82 ◽

2017 ◽

pp. 1035-1046

Author(s):

Dong-Sung Lee ◽

Seung-Hong Lee ◽

You-Jin Jeon ◽

Sun Hee Cheong

Keyword(s):

Oxidative Stress ◽

Water Extract ◽

Zebrafish Embryos ◽

Short Neck ◽

Tapes Philippinarum ◽

Antioxidant Effects

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Dried Ginger (Zingiber officinalis) Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/914563 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 17

Author(s):

You Yeon Choi ◽

Mi Hye Kim ◽

Jongki Hong ◽

Sung-Hoon Kim ◽

Woong Mo Yang

Keyword(s):

Water Extract ◽

Clinical Settings ◽

Protein Factor ◽

Therapeutic Benefits ◽

History Of ◽

Human Use ◽

Anti Inflammatory ◽

Oxide Synthase ◽

Inducible Nitric Oxide ◽

Inflammatory Effect

Objectives. Ginger rhizomes have a long history of human use, especially with regards to their anti-inflammatory properties. However, the mechanisms by which ginger acts on lipopolysaccharide-(LPS-)induced inflammation have not yet been identified. We investigated the anti-inflammatory effects of driedZingiber officinalis(DZO) on LPS-induced hepatic injury.Methods. ICR mice were given a DZO water extract (100, 1000 mg/kg) orally for three consecutive days. On the third day, they were administered by LPS intraperitoneally. To investigate the anti-inflammatory effects of DZO, histological, cytokine expression, and protein factor analyses were performed.Results. Oral administration of DZO significantly reduced pathological changes in the liver and proinflammatory cytokines including interferon-(IFN-)γand interleukin-(IL-)6 in the serum. In addition, DZO inhibited LPS-induced NF-κB activation by preventing degradation of the IκB-α, as well as the phosphorylation of ERK1/2, SAPK/JNK, and p38 MAPKs. These were associated with a decrease in the expression of inducible nitric oxide synthase (iNOS) and cyclooxyenase-2 (COX-2).Conclusions. Our data provide evidence for the hepatoprotective mechanisms of DZO as an anti-inflammatory effect. Furthermore, use of DZO to treat could provide therapeutic benefits in clinical settings.

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