Anti-inflammatory effect of Naravelia zeylanica DC via suppression of inflammatory mediators in carrageenan-induced abdominal oedema in zebrafish model

2017 ◽  
Vol 25 (1) ◽  
pp. 147-158 ◽  
Author(s):  
Sanmuga Priya Ekambaram ◽  
Senthamil Selvan Perumal ◽  
Selvaranjani Pavadai
Keyword(s):  
Inflammatory Mediators ◽  
Zebrafish Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Inhibition of the pro-inflammatory mediators’ production and anti-inflammatory effect of the iridoid scrovalentinoside

2007 ◽  
Vol 110 (3) ◽  
pp. 419-427 ◽  
Author(s):  
Esperanza Bas ◽  
M. Carmen Recio ◽  
Mohamed Abdallah ◽  
Salvador Máñez ◽  
Rosa M. Giner ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Resveratrol exerts anti-inflammatory effect in lipopolysaccharide-induced lung inflammation via downregulation of antioxidant and inflammatory mediators

2021 ◽  
Vol 17 (74) ◽  
pp. 275
Author(s):  
Xiaoming CHi ◽  
Xinxin Liang ◽  
Jian Shen ◽  
Xueming Duan ◽  
Rongbing Zhou ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Lung Inflammation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory effect of Sinhyowoldo-san Extract with regard to Pro-inflammatory Mediators in PMA plus A23187-induced Human Mast Cells

2014 ◽  
Vol 29 (6) ◽  
pp. 117-123
Author(s):  
Gyeong Wi ◽  
Da-Wun Yang ◽  
Ok-Hwa Kang ◽  
Sung-Bae Kim ◽  
Su-Hyun Mun ◽  
...  
Keyword(s):  
Mast Cells ◽  
Inflammatory Mediators ◽  
Human Mast Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-Inflammatory Effect of Lycii radicis in LPS-Stimulated RAW 264.7 Macrophages

2014 ◽  
Vol 42 (04) ◽  
pp. 891-904 ◽  
Author(s):  
Mi Young Song ◽  
Hyo Won Jung ◽  
Seok Yong Kang ◽  
Kyung-Ho Kim ◽  
Yong-Ki Park
Keyword(s):  
Inflammatory Cytokines ◽  
Inflammatory Mediators ◽  
Water Extract ◽  
Inhibitory Effect ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Root Bark ◽  
Lycium Barbarum ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The root bark of Lycium barbarum (Lycii radicis cortex, LRC) is used as a cooling agent for fever and night sweats in East Asian traditional medicine. The inhibitory effect of LRC water extract on inflammation is unknown. In this study, the anti-inflammatory effect of LRC was investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage, RAW 264.7 cells. LRC extract significantly decreased the LPS-induced production of inflammatory mediators, nitric oxide (NO), prostaglandin (PG) E2 and pro-inflammatory cytokines, interleukin (IL)-1β and IL-6 in the cells. In addition, LRC extract inhibited the LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, and inflammatory cytokines mRNA in the cells. The action mechanism of LRC underlies the blocking of LPS-mediated p38 and Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPKs), and the nuclear factor (NF)-κB signaling pathway. These results indicate that LRC extract inhibits the inflammatory response in activated macrophages by down-regulating the transcription levels of inflammatory mediators and blocking the MAPKs and NF-κB pathway.

scholarly journals Anti-inflammatory effect of lipophilic grape seed proanthocyanidin in RAW 264.7 cells and a zebrafish model

2020 ◽  
Vol 75 ◽  
pp. 104217
Author(s):  
Linli Zhang ◽  
Jun Chen ◽  
Hejing Liao ◽  
Changhong Li ◽  
Mingshun Chen
Keyword(s):  
Grape Seed ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Zebrafish Model ◽  
Grape Seed Proanthocyanidin ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Molecular mechanisms of the effects of the ethanolic extract of Muntingia calabura Linn. fruit on lipopolysaccharide-induced pro-inflammatory mediators in macrophages

2017 ◽  
Vol 8 (3) ◽  
pp. 1245-1253 ◽  
Author(s):  
Jau-Tien Lin ◽  
Yuan-Yen Chang ◽  
Yi-Chen Chen ◽  
Bo-Yan Shen ◽  
Deng-Jye Yang
Keyword(s):  
Inflammatory Mediators ◽  
Molecular Mechanisms ◽  
Ethanolic Extract ◽  
Anti Inflammatory ◽  
Muntingia Calabura ◽  
Inflammatory Effect

The anti-inflammatory effect and mechanisms ofM. calaburaLinn. fruit.

Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model

2013 ◽  
Vol 92 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Seung-Hong Lee ◽  
Chang-Ik Ko ◽  
Youngheun Jee ◽  
Yoonhwa Jeong ◽  
Misook Kim ◽  
...  
Keyword(s):  
Ecklonia Cava ◽  
Zebrafish Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Novel Analgesics with Peripheral Targets

2020 ◽  
Vol 17 (3) ◽  
pp. 784-825
Author(s):  
Cosmin I. Ciotu ◽  
Michael J. M. Fischer
Keyword(s):  
Sensory Neurons ◽  
Inflammatory Mediators ◽  
Inflammatory Process ◽  
Early Stage ◽  
Cellular Level ◽  
Proinflammatory Mediators ◽  
Inflammation Targeting ◽  
Anti Inflammatory ◽  
Current Stage ◽  
Inflammatory Effect

Abstract A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory process, of which an analgesic effect secondary to an anti-inflammatory effect can be expected. Different approaches to address these systems are discussed, including scavenging proinflammatory mediators, applying anti-inflammatory mediators, and inhibiting proinflammatory or facilitating anti-inflammatory receptors. New approaches are contrasted to established ones; the current stage of progress is mentioned, in particular considering whether there is data from a molecular and cellular level, from animals, or from human trials, including an early stage after a market release. An overview of publication activity is presented, considering a IuPhar/BPS-curated list of targets with restriction to pain-related publications, which was also used to identify topics.

scholarly journals Exploration of Anti-inflammatory Mechanism of Forsythiaside A and Forsythiaside B in CuSO4-Induced Inflammation in Zebrafish by Metabolomic and Proteomic Analyses

2019 ◽  
Author(s):  
Lihong Gong ◽  
Linyuan Yu ◽  
Xiaohong Gong ◽  
Cheng Wang ◽  
Naihua Hu ◽  
...  
Keyword(s):  
Sugar Metabolism ◽  
Amino Sugar ◽  
Zebrafish Model ◽  
Zebrafish Larvae ◽  
Chemically Induced ◽  
Inflammatory Mechanism ◽  
Forsythia Suspensa ◽  
Proteomic Analyses ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Abstract Background: Inflammation is a general pathological phenomenon that operates during severe disturbance of homeostasis. Forsythiaside A (FA) and Forsythiaside B (FB) are isolated from air-dried fruits of Forsythia suspensa, which show a significant effect against inflammation. However, the anti-inflammatory effect and therapeutic mechanism have not yet been clarified in zebrafish. Methods: In this study, the anti-inflammatory effects of FA and FB were investigated in CuSO4-induced zebrafish model. Intracellular ROS and NO generation in zebrafish were performed using fluorescent probe dyes. Metabolomics and proteomics using liquid chromatography mass spectrometry were carried out to identify the expression of metabolites and proteins associated with chemically induced inflammation in zebrafish larvae. Quantitative PCR was performed to detect the progressive changes in the genes.Results: FA and FB inhibited neutrophils migration to the damaged neuromasts and remarkably reduced CuSO4-induced ROS and NO generation in zebrafish. Metabolomics analyses indicated that the Nicotinate and nicotinamide metabolism, Amino sugar and nucleotide sugar metabolism, Pyrimidine metabolism and Purine metabolism were mainly involved. The proteomic analyses identified 146 differentially expressed proteins, among which, the expression of collagen (col2a1b, col9a2, col9a1b), nme3, wdr3, mrps7, srpx, gch2, ptpn11a, rcvrn2, nit2, scaf4a and zgc:162509 were all reversed both in FA and FB groups. FA and FB could reverse the abnormal expression of these metabolites and proteins to alleviate chemical damage to the neuromasts in the lateral line of zebrafish.Conclusions: FA and FB possess remarkable anti-inflammatory effect and could be used to protect chemically induced neuromasts damage in zebrafish larvae.

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