Lung Microvascular Endothelium as a Putative Progenitor Cell Niche

2015 ◽  
pp. 203-219
Author(s):  
Lauren Hartman ◽  
Troy Stevens
Keyword(s):  
Progenitor Cell ◽  
Microvascular Endothelium ◽  
Cell Niche

530 CHARACTERISATION OF THE LIVER PROGENITOR CELL NICHE

2008 ◽  
Vol 48 ◽  
pp. S199
Author(s):  
B. Spee ◽  
S. Vanderborght ◽  
M. Komuta ◽  
G. Carpino ◽  
B.A. Schotanus ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Cell Niche ◽  
Liver Progenitor Cell

Cardiac embryogenesis

ESC CardioMed ◽  
2018 ◽  
pp. 33-36
Author(s):  
Robert G. Kelly
Keyword(s):  
Progenitor Cells ◽  
Progenitor Cell ◽  
Congenital Heart ◽  
Heart Defects ◽  
Embryonic Heart ◽  
Heart Tube ◽  
Second Heart Field ◽  
Heart Field ◽  
Cell Niche ◽  
The Right

The embryonic heart forms in anterior lateral splanchnic mesoderm and is derived from Mesp1-expressing progenitor cells. During embryonic folding, the earliest differentiating progenitor cells form the linear heart tube in the ventral midline. The heart tube extends in length and loops to the right as new myocardium is progressively added at the venous and arterial poles from multipotent second heart field cardiovascular progenitor cells in contiguous pharyngeal mesoderm. While the linear heart tube gives rise to the left ventricle, the right ventricle, outflow tract, and a large part of atrial myocardium are derived from the second heart field. Progressive myocardial differentiation is controlled by intercellular signals within the progenitor cell niche. The embryonic heart is the template for septation and growth of the four-chambered definitive heart and defects in progenitor cell deployment result in a spectrum of common forms of congenital heart defects.

scholarly journals Redox Control of the Immune Response in the Hepatic Progenitor Cell Niche

2020 ◽  
Vol 8 ◽  
Author(s):  
Francesco Bellanti ◽  
Giuseppe Pannone ◽  
Nicola Tartaglia ◽  
Gaetano Serviddio
Keyword(s):  
Immune Response ◽  
Progenitor Cell ◽  
Redox Control ◽  
Hepatic Progenitor Cell ◽  
Cell Niche

scholarly journals e0193 A critical role of ckit in CXCR4-mediated progenitor cell niche maintenance and mobilisation

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A62-A62
Author(s):  
C. Min ◽  
Z. Qiutang ◽  
L. Douglas
Keyword(s):  
Progenitor Cell ◽  
Critical Role ◽  
Cell Niche

scholarly journals Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Jessica M. Gluck ◽  
Jennifer Chyu ◽  
Connor Delman ◽  
Sepideh Heydarkhan-Hagvall ◽  
W. Robb MacLellan ◽  
...  
Keyword(s):  
Cell Fate ◽  
Progenitor Cell ◽  
Three Dimensional ◽  
Extrinsic Factors ◽  
Cell Fate Decisions ◽  
3D Microenvironment ◽  
Cell Niche ◽  
The Relationship ◽  
Stem Cell Niches

The relationship between stem cell niches in vivo and their surrounding microenvironment is still relatively unknown. Recent advances have indicated that extrinsic factors within the cardiovascular progenitor cell niche influence maintenance of a multipotent state as well as drive cell-fate decisions. We have previously shown the direct effects of extracellular matrix (ECM) proteins and have now investigated the effects of dimension on the induction of a cardiovascular progenitor cell (CPC) population. We have shown here that the three-dimensionality of a hyaluronan-based hydrogel greatly induces a CPC population, as marked by Flk-1. We have compared the effects of a 3D microenvironment to those of conventional 2D cell culture practices and have found that the 3D microenvironment potently induces a progenitor cell state.

scholarly journals Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche

2020 ◽  
Vol 11 (10) ◽  
Author(s):  
Xiaohong Peng ◽  
Yi Wu ◽  
Uilke Brouwer ◽  
Thijmen van Vliet ◽  
Boshi Wang ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cellular Senescence ◽  
Progenitor Cell ◽  
Tissue Degeneration ◽  
Cycle Arrest ◽  
Radiation Induced ◽  
Secretory Phenotype ◽  
Cell Niche ◽  
Gland Function ◽  
Formation Efficiency

Abstract Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent state of cell cycle arrest accompanied by a secretory phenotype which contributes to inflammation and tissue deterioration. Genotoxic stresses, including radiation-induced DNA damage, are known to induce a senescence response. Here, we show that radiation induces cellular senescence preferentially in the salivary gland stem/progenitor cell niche of mouse models and patients. Similarly, salivary gland-derived organoids show increased expression of senescence markers and pro-inflammatory senescence-associated secretory phenotype (SASP) factors after radiation exposure. Clearance of senescent cells by selective removal of p16Ink4a-positive cells by the drug ganciclovir or the senolytic drug ABT263 lead to increased stem cell self-renewal capacity as measured by organoid formation efficiency. Additionally, pharmacological treatment with ABT263 in mice irradiated to the salivary glands mitigates tissue degeneration, thus preserving salivation. Our data suggest that senescence in the salivary gland stem/progenitor cell niche contributes to radiation-induced hyposalivation. Pharmacological targeting of senescent cells may represent a therapeutic strategy to prevent radiotherapy-induced xerostomia.

The canine hepatic progenitor cell niche: Molecular characterisation in health and disease

2014 ◽  
Vol 201 (3) ◽  
pp. 345-352 ◽  
Author(s):  
H.S. Kruitwagen ◽  
B. Spee ◽  
C.S. Viebahn ◽  
H.B. Venema ◽  
L.C. Penning ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Molecular Characterisation ◽  
Hepatic Progenitor Cell ◽  
Health And Disease ◽  
Cell Niche
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