scholarly journals Src Family Kinases in Brain Edema After Acute Brain Injury

2016 ◽  
pp. 185-190 ◽  
Author(s):  
DaZhi Liu ◽  
Xiong Zhang ◽  
BeiLei Hu ◽  
Bradley P. Ander
Keyword(s):  
Brain Injury ◽  
Brain Edema ◽  
Src Family Kinases ◽  
Acute Brain Injury

A methodology for detecting and exploring non-convulsive seizures in patients with acute brain injury

2014 ◽  
Vol 2 ◽  
pp. 396-399 ◽  
Author(s):  
DJ Albers ◽  
J Claassen ◽  
M Schmidt ◽  
G Hripcsak
Keyword(s):  
Brain Injury ◽  
Acute Brain Injury ◽  
Convulsive Seizures

Alterations of blood IL-8, TGF-beta1 and nitric oxide levels in relation to blood cells in patients with acute brain injury

Therapy ◽  
2006 ◽  
Vol 3 (3) ◽  
pp. 399-405
Author(s):  
Elham Hadidi ◽  
Mojtaba Mojtahedzadeh ◽  
Mohammad Hassan Paknejad ◽  
Shekoufeh Nikfar ◽  
Mohammad Jafar Zamani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Brain Injury ◽  
Blood Cells ◽  
Acute Brain Injury

scholarly journals Ulinastatin alleviates traumatic brain injury by reducing endothelin-1

2020 ◽  
Vol 12 (1) ◽  
pp. 001-008
Author(s):  
Ting Liu ◽  
Xing-Zhi Liao ◽  
Mai-Tao Zhou
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Western Blot ◽  
Water Content ◽  
Brain Edema ◽  
Rat Model ◽  
Neurosurgical Procedures ◽  
Brain Water Content ◽  
The Brain ◽  
Brain Water

Abstract Background Brain edema is one of the major causes of fatality and disability associated with injury and neurosurgical procedures. The goal of this study was to evaluate the effect of ulinastatin (UTI), a protease inhibitor, on astrocytes in a rat model of traumatic brain injury (TBI). Methodology A rat model of TBI was established. Animals were randomly divided into 2 groups – one group was treated with normal saline and the second group was treated with UTI (50,000 U/kg). The brain water content and permeability of the blood–brain barrier were assessed in the two groups along with a sham group (no TBI). Expression of the glial fibrillary acidic protein, endthelin-1 (ET-1), vascular endothelial growth factor (VEGF), and matrix metalloproteinase 9 (MMP-9) were measured by immunohistochemistry and western blot. Effect of UTI on ERK and PI3K/AKT signaling pathways was measured by western blot. Results UTI significantly decreased the brain water content and extravasation of the Evans blue dye. This attenuation was associated with decreased activation of the astrocytes and ET-1. UTI treatment decreased ERK and Akt activation and inhibited the expression of pro-inflammatory VEGF and MMP-9. Conclusion UTI can alleviate brain edema resulting from TBI by inhibiting astrocyte activation and ET-1 production.

A pre-injury high ethanol intake in rats promotes brain edema following traumatic brain injury

2014 ◽  
Vol 28 (6) ◽  
pp. 739-745 ◽  
Author(s):  
Weichuan Wu ◽  
Runfa Tian ◽  
Shuyu Hao ◽  
Feifan Xu ◽  
Xiang Mao ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Edema ◽  
Ethanol Intake ◽  
High Ethanol

Heart rate and blood pressure variability and baroreflex sensitivity in patients with acute brain injury

2005 ◽  
Vol 20 (4) ◽  
pp. 394 ◽  
Author(s):  
V. Papaioannou ◽  
M. Giannakou ◽  
N. Maglaveras ◽  
E. Sofianos ◽  
M. Giala
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Brain Injury ◽  
Blood Pressure Variability ◽  
Baroreflex Sensitivity ◽  
Acute Brain Injury

The Tangled History of Brain–Heart Pathways in Acute Brain Injury

2021 ◽  
Author(s):  
Eelco F. M. Wijdicks
Keyword(s):  
Brain Injury ◽  
Acute Brain Injury ◽  
History Of

scholarly journals Outcome Prognostication of Acute Brain Injury using the Neurological Pupil Index (ORANGE) study: protocol for a prospective, observational, multicentre, international cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e046948
Author(s):  
Mauro Oddo ◽  
Fabio Taccone ◽  
Stefania Galimberti ◽  
Paola Rebora ◽  
Giuseppe Citerio
Keyword(s):  
Brain Injury ◽  
Latent Class ◽  
Acute Brain Injury ◽  
Institutional Review ◽  
Infrared Pupillometry ◽  
Poor Neurological Outcome ◽  
Registration Number ◽  
Poor Outcomes ◽  
Injured Patients ◽  
Neurological Pupil Index

IntroductionThe pupillary examination is an important part of the neurological assessment, especially in the setting of acutely brain-injured patients, and pupillary abnormalities are associated with poor outcomes. Currently, the pupillary examination is based on a visual, subjective and frequently inaccurate estimation. The use of automated infrared pupillometry to measure the pupillary light reflex can precisely quantify subtle changes in pupillary functions. The study aimed to evaluate the association between abnormal pupillary function, assessed by the Neurological Pupil Index (NPi), and long-term outcomes in patients with acute brain injury (ABI).Methods and analysisThe Outcome Prognostication of Acute Brain Injury using the Neurological Pupil Index study is a prospective, observational study including adult patients with ABI requiring admission at the intensive care unit. We aimed to recruit at least 420 patients including those suffering from traumatic brain injury or haemorrhagic strokes, over 12 months. The primary aim was to assess the relationship between NPi and 6-month mortality or poor neurological outcome, measured by the Extended Glasgow Outcome Score (GOS-E, poor outcome=GOS-E 1–4). Supervised and unsupervised methods and latent class mixed models will be used to identify patterns of NPi trajectories and Cox and logistic model to evaluate their association with outcome.Ethics and disseminationThe study has been approved by the institutional review board (Comitato Etico Brianza) on 16 July 2020. Approved protocol V.4.0 dated 10 March 2020. The results of this study will be published in peer-reviewed journals and presented at conferences.Trial registration numberNCT04490005.

scholarly journals Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits

2012 ◽  
Vol 13 (1) ◽  
pp. 47 ◽  
Author(s):  
Zong Zhuang ◽  
Meng-liang Zhou ◽  
Wan-chun You ◽  
Lin Zhu ◽  
Chi-yuan Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Brain Edema ◽  
Early Brain Injury ◽  
Experimental Subarachnoid Hemorrhage

Reliability and Validity of the PERPOS for Post-Acute Brain Injury Rehabilitation

2015 ◽  
Vol 96 (10) ◽  
pp. e31
Author(s):  
Carlos Daniel Marquez de la Plata ◽  
Lisa Morgan ◽  
Devin Qualls ◽  
Patrick Michael Plenger ◽  
Richard M. Capriotti ◽  
...  
Keyword(s):  
Brain Injury ◽  
Reliability And Validity ◽  
Acute Brain Injury ◽  
Injury Rehabilitation
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