A Replicator Dynamics Approach to Collective Feature Engineering in Random Forests

Author(s):  
Khaled Fawgreh ◽  
Mohamed Medhat Gaber ◽  
Eyad Elyan
2019 ◽  
Author(s):  
Oskar Flygare ◽  
Jesper Enander ◽  
Erik Andersson ◽  
Brjánn Ljótsson ◽  
Volen Z Ivanov ◽  
...  

**Background:** Previous attempts to identify predictors of treatment outcomes in body dysmorphic disorder (BDD) have yielded inconsistent findings. One way to increase precision and clinical utility could be to use machine learning methods, which can incorporate multiple non-linear associations in prediction models. **Methods:** This study used a random forests machine learning approach to test if it is possible to reliably predict remission from BDD in a sample of 88 individuals that had received internet-delivered cognitive behavioral therapy for BDD. The random forest models were compared to traditional logistic regression analyses. **Results:** Random forests correctly identified 78% of participants as remitters or non-remitters at post-treatment. The accuracy of prediction was lower in subsequent follow-ups (68%, 66% and 61% correctly classified at 3-, 12- and 24-month follow-ups, respectively). Depressive symptoms, treatment credibility, working alliance, and initial severity of BDD were among the most important predictors at the beginning of treatment. By contrast, the logistic regression models did not identify consistent and strong predictors of remission from BDD. **Conclusions:** The results provide initial support for the clinical utility of machine learning approaches in the prediction of outcomes of patients with BDD. **Trial registration:** ClinicalTrials.gov ID: NCT02010619.


2013 ◽  
Vol 10 (1) ◽  
pp. 38-44
Author(s):  
Smitha Sunil Nair ◽  
N. V. Reddy ◽  
K. Hareesha ◽  
S. Balaji

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alvaro Ras-Carmona ◽  
Marta Gomez-Perosanz ◽  
Pedro A. Reche

Abstract Motivation In eukaryotes, proteins targeted for secretion contain a signal peptide, which allows them to proceed through the conventional ER/Golgi-dependent pathway. However, an important number of proteins lacking a signal peptide can be secreted through unconventional routes, including that mediated by exosomes. Currently, no method is available to predict protein secretion via exosomes. Results Here, we first assembled a dataset including the sequences of 2992 proteins secreted by exosomes and 2961 proteins that are not secreted by exosomes. Subsequently, we trained different random forests models on feature vectors derived from the sequences in this dataset. In tenfold cross-validation, the best model was trained on dipeptide composition, reaching an accuracy of 69.88% ± 2.08 and an area under the curve (AUC) of 0.76 ± 0.03. In an independent dataset, this model reached an accuracy of 75.73% and an AUC of 0.840. After these results, we developed ExoPred, a web-based tool that uses random forests to predict protein secretion by exosomes. Conclusion ExoPred is available for free public use at http://imath.med.ucm.es/exopred/. Datasets are available at http://imath.med.ucm.es/exopred/datasets/.


Author(s):  
Jasmine Ye Nakayama ◽  
Joyce Ho ◽  
Emily Cartwright ◽  
Roy Simpson ◽  
Vicki Stover Hertzberg

Games ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 8
Author(s):  
Gustavo Chica-Pedraza ◽  
Eduardo Mojica-Nava ◽  
Ernesto Cadena-Muñoz

Multi-Agent Systems (MAS) have been used to solve several optimization problems in control systems. MAS allow understanding the interactions between agents and the complexity of the system, thus generating functional models that are closer to reality. However, these approaches assume that information between agents is always available, which means the employment of a full-information model. Some tendencies have been growing in importance to tackle scenarios where information constraints are relevant issues. In this sense, game theory approaches appear as a useful technique that use a strategy concept to analyze the interactions of the agents and achieve the maximization of agent outcomes. In this paper, we propose a distributed control method of learning that allows analyzing the effect of the exploration concept in MAS. The dynamics obtained use Q-learning from reinforcement learning as a way to include the concept of exploration into the classic exploration-less Replicator Dynamics equation. Then, the Boltzmann distribution is used to introduce the Boltzmann-Based Distributed Replicator Dynamics as a tool for controlling agents behaviors. This distributed approach can be used in several engineering applications, where communications constraints between agents are considered. The behavior of the proposed method is analyzed using a smart grid application for validation purposes. Results show that despite the lack of full information of the system, by controlling some parameters of the method, it has similar behavior to the traditional centralized approaches.


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