Predictors of remission from body dysmorphic disorder after internet-delivered cognitive behavior therapy: a machine learning approach

2019 ◽  
Author(s):  
Oskar Flygare ◽  
Jesper Enander ◽  
Erik Andersson ◽  
Brjánn Ljótsson ◽  
Volen Z Ivanov ◽  
...  
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Random Forests ◽  
Clinical Utility ◽  
Body Dysmorphic Disorder ◽  
Prediction Models ◽  
Behavioral Therapy ◽  
Learning Approach ◽  
Learning Approaches ◽  
Machine Learning Approach

**Background:** Previous attempts to identify predictors of treatment outcomes in body dysmorphic disorder (BDD) have yielded inconsistent findings. One way to increase precision and clinical utility could be to use machine learning methods, which can incorporate multiple non-linear associations in prediction models. **Methods:** This study used a random forests machine learning approach to test if it is possible to reliably predict remission from BDD in a sample of 88 individuals that had received internet-delivered cognitive behavioral therapy for BDD. The random forest models were compared to traditional logistic regression analyses. **Results:** Random forests correctly identified 78% of participants as remitters or non-remitters at post-treatment. The accuracy of prediction was lower in subsequent follow-ups (68%, 66% and 61% correctly classified at 3-, 12- and 24-month follow-ups, respectively). Depressive symptoms, treatment credibility, working alliance, and initial severity of BDD were among the most important predictors at the beginning of treatment. By contrast, the logistic regression models did not identify consistent and strong predictors of remission from BDD. **Conclusions:** The results provide initial support for the clinical utility of machine learning approaches in the prediction of outcomes of patients with BDD. **Trial registration:** ClinicalTrials.gov ID: NCT02010619.

Mol2vec: Unsupervised Machine Learning Approach with Chemical Intuition

2017 ◽  
Author(s):  
Sabrina Jaeger ◽  
Simone Fulle ◽  
Samo Turk
Keyword(s):  
Machine Learning ◽  
Language Processing ◽  
Supervised Machine Learning ◽  
Learning Approach ◽  
Learning Approaches ◽  
Unsupervised Machine Learning ◽  
Feature Representations ◽  
Machine Learning Approach ◽  
The Individual ◽  
Vector Representations

Inspired by natural language processing techniques we here introduce Mol2vec which is an unsupervised machine learning approach to learn vector representations of molecular substructures. Similarly, to the Word2vec models where vectors of closely related words are in close proximity in the vector space, Mol2vec learns vector representations of molecular substructures that are pointing in similar directions for chemically related substructures. Compounds can finally be encoded as vectors by summing up vectors of the individual substructures and, for instance, feed into supervised machine learning approaches to predict compound properties. The underlying substructure vector embeddings are obtained by training an unsupervised machine learning approach on a so-called corpus of compounds that consists of all available chemical matter. The resulting Mol2vec model is pre-trained once, yields dense vector representations and overcomes drawbacks of common compound feature representations such as sparseness and bit collisions. The prediction capabilities are demonstrated on several compound property and bioactivity data sets and compared with results obtained for Morgan fingerprints as reference compound representation. Mol2vec can be easily combined with ProtVec, which employs the same Word2vec concept on protein sequences, resulting in a proteochemometric approach that is alignment independent and can be thus also easily used for proteins with low sequence similarities.

scholarly journals Development of Machine Learning Models to Predict Probabilities and Types of Stroke at Prehospital Stage: the Japan Urgent Stroke Triage Score Using Machine Learning (JUST-ML)

2021 ◽  
Author(s):  
Kazutaka Uchida ◽  
Junichi Kouno ◽  
Shinichi Yoshimura ◽  
Norito Kinjo ◽  
Fumihiro Sakakibara ◽  
...  
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Random Forests ◽  
Prediction Models ◽  
Characteristic Curve ◽  
Predictive Performance ◽  
Vessel Occlusion ◽  
Predictive Values ◽  
Training Cohort ◽  
Sensitivity Specificity

AbstractIn conjunction with recent advancements in machine learning (ML), such technologies have been applied in various fields owing to their high predictive performance. We tried to develop prehospital stroke scale with ML. We conducted multi-center retrospective and prospective cohort study. The training cohort had eight centers in Japan from June 2015 to March 2018, and the test cohort had 13 centers from April 2019 to March 2020. We use the three different ML algorithms (logistic regression, random forests, XGBoost) to develop models. Main outcomes were large vessel occlusion (LVO), intracranial hemorrhage (ICH), subarachnoid hemorrhage (SAH), and cerebral infarction (CI) other than LVO. The predictive abilities were validated in the test cohort with accuracy, positive predictive value, sensitivity, specificity, area under the receiver operating characteristic curve (AUC), and F score. The training cohort included 3178 patients with 337 LVO, 487 ICH, 131 SAH, and 676 CI cases, and the test cohort included 3127 patients with 183 LVO, 372 ICH, 90 SAH, and 577 CI cases. The overall accuracies were 0.65, and the positive predictive values, sensitivities, specificities, AUCs, and F scores were stable in the test cohort. The classification abilities were also fair for all ML models. The AUCs for LVO of logistic regression, random forests, and XGBoost were 0.89, 0.89, and 0.88, respectively, in the test cohort, and these values were higher than the previously reported prediction models for LVO. The ML models developed to predict the probability and types of stroke at the prehospital stage had superior predictive abilities.

scholarly journals Validation of an Internationally Derived Patient Severity Phenotype to Support COVID-19 Analytics from Electronic Health Record Data

2021 ◽  
Author(s):  
Jeffrey G Klann ◽  
Griffin M Weber ◽  
Hossein Estiri ◽  
Bertrand Moal ◽  
Paul Avillach ◽  
...  
Keyword(s):  
Machine Learning ◽  
Electronic Health Record ◽  
Chart Review ◽  
Learning Approach ◽  
Health Record ◽  
Learning Approaches ◽  
Electronic Health Record Data ◽  
Icu Admission ◽  
Machine Learning Approach ◽  
Electronic Health

Abstract Introduction The Consortium for Clinical Characterization of COVID-19 by EHR (4CE) is an international collaboration addressing COVID-19 with federated analyses of electronic health record (EHR) data. Objective We sought to develop and validate a computable phenotype for COVID-19 severity. Methods Twelve 4CE sites participated. First we developed an EHR-based severity phenotype consisting of six code classes, and we validated it on patient hospitalization data from the 12 4CE clinical sites against the outcomes of ICU admission and/or death. We also piloted an alternative machine-learning approach and compared selected predictors of severity to the 4CE phenotype at one site. Results The full 4CE severity phenotype had pooled sensitivity of 0.73 and specificity 0.83 for the combined outcome of ICU admission and/or death. The sensitivity of individual code categories for acuity had high variability - up to 0.65 across sites. At one pilot site, the expert-derived phenotype had mean AUC 0.903 (95% CI: 0.886, 0.921), compared to AUC 0.956 (95% CI: 0.952, 0.959) for the machine-learning approach. Billing codes were poor proxies of ICU admission, with as low as 49% precision and recall compared to chart review. Discussion We developed a severity phenotype using 6 code classes that proved resilient to coding variability across international institutions. In contrast, machine-learning approaches may overfit hospital-specific orders. Manual chart review revealed discrepancies even in the gold-standard outcomes, possibly due to heterogeneous pandemic conditions. Conclusion We developed an EHR-based severity phenotype for COVID-19 in hospitalized patients and validated it at 12 international sites.

scholarly journals Prediksi Not Operational Transaction Menggunakan Logistic Regression pada Bank XYZ di Kota Kupang

AITI ◽  
2020 ◽  
Vol 17 (1) ◽  
pp. 42-55
Author(s):  
Radius Tanone ◽  
Arnold B Emmanuel
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Regression Method ◽  
Learning Approach ◽  
Know How ◽  
Independent Variables ◽  
Machine Learning Approach ◽  
Logistic Regression Method ◽  
Python Programming

Bank XYZ is one of the banks in Kupang City, East Nusa Tenggara Province which has several ATM machines and is placed in several merchant locations. The existing ATM machine is one of the goals of customers and non-customers in conducting transactions at the ATM machine. The placement of the ATM machines sometimes makes the machine not used optimally by the customer to transact, causing the disposal of machine resources and a condition called Not Operational Transaction (NOP). With the data consisting of several independent variables with numeric types, it is necessary to know how the classification of the dependent variable is NOP. Machine learning approach with Logistic Regression method is the solution in doing this classification. Some research steps are carried out by collecting data, analyzing using machine learning using python programming and writing reports. The results obtained with this machine learning approach is the resulting prediction value of 0.507 for its classification. This means that in the future XYZ Bank can classify NOP conditions based on the behavior of customers or non-customers in making transactions using Bank XYZ ATM machines.  

scholarly journals COVID-19 Pandemic Prediction for Hungary; a Hybrid Machine Learning Approach

2020 ◽  
Author(s):  
Amir Mosavi
Keyword(s):  
Machine Learning ◽  
Prediction Models ◽  
Future Research ◽  
Complex Nature ◽  
Learning Approach ◽  
Epidemiological Models ◽  
Inference System ◽  
Proper Actions ◽  
Machine Learning Approach ◽  
Hybrid Machine

Several epidemiological models are being used around the world to project the number of infected individuals and the mortality rates of the COVID-19 outbreak. Advancing accurate prediction models is of utmost importance to take proper actions. Due to a high level of uncertainty or even lack of essential data, the standard epidemiological models have been challenged regarding the delivery of higher accuracy for long-term prediction. As an alternative to the susceptible-infected-resistant (SIR)-based models, this study proposes a hybrid machine learning approach to predict the COVID-19 and we exemplify its potential using data from Hungary. The hybrid machine learning methods of adaptive network-based fuzzy inference system (ANFIS) and multi-layered perceptron-imperialist competitive algorithm (MLP-ICA) are used to predict time series of infected individuals and mortality rate. The models predict that by late May, the outbreak and the total morality will drop substantially. The validation is performed for nine days with promising results, which confirms the model accuracy. It is expected that the model maintains its accuracy as long as no significant interruption occurs. Based on the results reported here, and due to the complex nature of the COVID-19 outbreak and variation in its behavior from nation-to-nation, this study suggests machine learning as an effective tool to model the outbreak. This paper provides an initial benchmarking to demonstrate the potential of machine learning for future research.

scholarly journals Analysis of Machine Learning Approach for the modemodel in SWC Mapping in Automotive Systems

2021 ◽  
Vol 7 (1) ◽  
pp. 16-19
Author(s):  
Owes Khan ◽  
Geri Shahini ◽  
Wolfram Hardt
Keyword(s):  
Machine Learning ◽  
Autonomous Driving ◽  
Learning Approach ◽  
Software Components ◽  
Control Mechanisms ◽  
Learning Approaches ◽  
Software Applications ◽  
Automotive Systems ◽  
Machine Learning Approach ◽  
Development Processes

Automotive technologies are ever-increasinglybecoming digital. Highly autonomous driving togetherwith digital E/E control mechanisms include thousandsof software applications which are called as software components. Together with the industry requirements, and rigorous software development processes, mappingof components as a software pool becomes very difficult.This article analyses and discusses the integration possiblilities of machine learning approaches to our previously introduced concept of mapping of software components through a common software pool.

scholarly journals Retinal Area Segmentation using Adaptive Superpixalation and its Classification using RBFN

2016 ◽  
Vol 6 (6) ◽  
pp. 2674
Author(s):  
Nimisha Singh ◽  
Rana Gill
Keyword(s):  
Machine Learning ◽  
Retinal Disease ◽  
Learning Approach ◽  
Learning Approaches ◽  
Retinal Area ◽  
Original Image ◽  
Feature Generation ◽  
Medical Field ◽  
Machine Learning Approach ◽  
Image Pattern

<p class="Abstract">Retinal disease is the very important issue in medical field. To diagnose the disease, it needs to detect the true retinal area. Artefacts like eyelids and eyelashes are come along with retinal part so removal of artefacts is the big task for better diagnosis of disease into the retinal part.  In this paper, we have proposed the segmentation and use machine learning approaches to detect the true retinal part. Preprocessing is done on the original image using Gamma Normalization which helps to enhance the image  that can gives detail information about the image. Then the segmentation is performed on the Gamma Normalized image by Superpixel method. Superpixel is the group of pixel into different regions which is based on compactness and regional size. Superpixel is used to reduce the complexity of image processing task and provide suitable primitive image pattern. Then feature generation must be done and machine learning approach helps to extract true retinal area. The experimental evaluation gives the better result with accuracy of 96%.</p>

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