Alzheimer’s Disease and Medicinal Plants: An Overview

2016 ◽  
pp. 95-105 ◽  
Author(s):  
S. Manoharan ◽  
M. Mohamed Essa ◽  
A. Vinoth ◽  
R. Kowsalya ◽  
A. Manimaran ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medicinal Plants

Natural product-based nanomedicine: Recent advances and issues for the treatment of Alzheimer's disease

2021 ◽  
Vol 20 ◽  
Author(s):  
Choy Ker Woon ◽  
Wong Kah Hui ◽  
Razif Abas ◽  
Muhammad Huzaimi Haron ◽  
Srijit Das ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Medicinal Plants ◽  
Drug Transport ◽  
The Elderly ◽  
Current Evidence ◽  
Alternative Approach ◽  
Progressive Neurodegeneration ◽  
The Brain

: Alzheimer's disease (AD) affects the elderly and is characterized by progressive neurodegeneration caused by different pathologies. The most significant challenges in treating AD include the inability of medications to reach the brain because of its poor solubility, low bioavailability, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and its severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano- sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material’s bioactivity. The review highlights the applications of medicinal plants, their derived components, and various nanomedicine-based approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future.

Medicinal Plants with Acetylcholinesterase Inhibitory Activity: Therapeutic Potential of Brazilian Plants for the Treatment of Alzheimer's Disease

2021 ◽  
Vol 13 (26) ◽  
pp. 45-49
Author(s):  
Fernanda Granja da Silva Oliveira ◽  
Bruno de Oliveira Veras ◽  
Juliane Maria Dos Santos Silva ◽  
Deyzi Caroline da Silva Barbosa ◽  
Tayane de Cássia Dias Mendes Silva ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medicinal Plants ◽  
Inhibitory Activity ◽  
Therapeutic Potential ◽  
Acetylcholinesterase Inhibitory Activity

Potential of South African medicinal plants targeting the reduction of Aβ42 protein as a treatment of Alzheimer's disease

2019 ◽  
Vol 231 ◽  
pp. 363-373 ◽  
Author(s):  
Anuradha Thakur ◽  
Yoon Sun Chun ◽  
Natasha October ◽  
Hyun Ok Yang ◽  
Vinesh Maharaj
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medicinal Plants ◽  
South African

Natural product for the treatment of Alzheimer’s disease

2017 ◽  
Vol 28 (5) ◽  
Author(s):  
Thanh Tung Bui ◽  
Thanh Hai Nguyen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Cognitive Function ◽  
Medicinal Plants ◽  
Neurodegenerative Disease ◽  
Natural Product ◽  
Natural Compound ◽  
Anti Inflammatory

AbstractAlzheimer’s disease (AD) is related to increasing age. It is mainly characterized by progressive neurodegenerative disease, which damages memory and cognitive function. Natural products offer many options to reduce the progress and symptoms of many kinds of diseases, including AD. Meanwhile, natural compound structures, including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, have anti-inflammatory, antioxidant, anti-amyloidogenic, and anticholinesterase activities. In this review, we summarize the pathogenesis and targets for treatment of AD. We also present several medicinal plants and isolated compounds that are used for preventing and reducing symptoms of AD.

Botanical Sources for Alzheimer’s: A Review on Reports From Traditional Persian Medicine

2017 ◽  
Vol 32 (7) ◽  
pp. 429-437 ◽  
Author(s):  
Ayda Hosseinkhani ◽  
Ali Sahragard ◽  
Aida Namdari ◽  
Mohammad M. Zarshenas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Mechanisms Of Action ◽  
Cholinesterase Inhibition ◽  
Clinical Validation ◽  
Persian Medicine ◽  
Traditional Persian Medicine ◽  
Butyryl Cholinesterase

Herbal medicines for the treatment of Alzheimer’s disease (AD) have attracted considerable attention nowadays. Alzheimer’s disease is described in traditional Persian medicine (TPM) by the term Nesyān. In this study, 5 main medicinal medieval Persian manuscripts were reviewed to filter plants reported for the treatment of Nesyān. Databases were searched for related possible mechanisms of action of these medicinal plants. Each herb was searched for along with these keywords: “acetyl and butyryl cholinesterase inhibition,” “antioxidant,” “anti-inflammatory,” and “anti-amyloidogenic.” In Total, 44 herbs were used for the treatment of Nesyān; 40 of those were authenticated. Also, 30 plants had at least one of the mechanisms of action that were searched for or related pharmacological functions known for the treatment of AD. In this work, we introduce promising candidates in TPM that could undergo further investigation for identification of their active compounds and clinical validation in the treatment of AD.

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