Antihyperuricemia Activity of the Ethyl Acetate Fraction of Bilimbi Leaves (Averrhoa bilimbi L.)

Hyperuricemia is a condition where there is an increase in uric acid levels above normal. An increase in the number of leukocytes is also a biological marker of hyperuricemia. The leaves of bilimbi (Averrhoa bilimbi L.) are one of the traditional medicinal plants which contain alkaloids, tannins, steroids, and flavonoid compounds. Flavonoid compounds are thought to inhibit the formation of uric acid in the body. This study investigates the antihyperuricemia activity of the ethyl acetate fraction of bilimbi leaves. The animals were male white mice grouped into six groups: the normal group, negative control, positive control (allopurinol), and the group was given the ethyl acetate fraction of bilimbi leaves at doses of 100, 200, and 400 mg/kg BW. Hyperuricemia induction is by giving high-purine diets and potassium oxonate. The results showed that the variation of the ethyl acetate fraction of bilimbi leaves significantly reduce uric acid levels and the number of leukocyte cells (sig <0.05). Giving ethyl acetate fraction at a dose of 400 mg/kg BW showed the best reduction in uric acid and leukocyte levels.

Ethnopharmacological Review of Traditional Medicinal Plants Found as an Astounding Remedy to Anemia

Iron deficiency is the predominant cause of anemia, which is a recurrent type of nutritional problem. Medicinal herbs have proven to be efficient in the treatment of a variety of ailments in developing countries, including anemia. Anemia is generally treated by hematinics in the form of tablets, capsules and syrup and sometimes injection. Long term intake of hematinics produces some side effects like Gastritis, tooth staining, etc. Many medicinal plants have the ability to treat anemia. Sorghum bicolor stem bark, Brillantasia nitens leaves, Tectona grandis, and Allium ascalonicum are just a few of the plants that have traditionally been used to treat anaemia. The current review aims to list out such medicinal plants along with their ethnopharmacological status in treating anemia.

Role of Botanical Herbs Used in Covid-19 Treatment and Cure

Corona 2019 (COVID-19) is a new infectious disease caused by acute respiratory syndrome corona virus 2 (SARS-CoV-2) which belongs to the family of corona viruses. The first case appeared in December 2019, and the disease has transformed into a pandemic. Physical disability control is one of the main parts that play a role in its disease and leads to adverse effects for COVID-19 patients. At present, people believe taking herbal treatment that can stop COVID-19. Medicinal plants can distribute as the therapeutic agents so it can help people to fight against the COVID-19 disease by boost their immunities. And such as, it can help to decrease the death rate that are linked with SARS-CoV-2 infections. So, in this analysis, we can make an effort to combine and talk about of different kind of traditional medicinal plants and their biological properties that can help to build-up our immune system and also play a biggest role in the fight against the viral infections including COVID-19. This document will help researchers and industry to recognize and assess in the making medicinal herb that can meet their needs in a variation of applications including herbal / ayurvedic antiviral products, anti-bacterial/antimicrobial design, immune-potentiator development, sanitization and sanitization programs.

Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds

Traditional medicinal plants contain a variety of bioactive natural products including cysteine-rich (Cys-rich) antimicrobial peptides (AMPs). Cys-rich AMPs are often crosslinked by multiple disulfide bonds which increase their resistance to chemical and enzymatic degradation. However, this class of molecules is relatively underexplored. Herein, in silico analysis predicted 80–100 Cys-rich AMPs per species from three edible traditional medicinal plants: Linum usitatissimum (flax), Trifolium pratense (red clover), and Sesamum indicum (sesame). Bottom-up proteomic analysis of seed peptide extracts revealed direct evidence for the translation of 3–10 Cys-rich AMPs per species, including lipid transfer proteins, defensins, α-hairpinins, and snakins. Negative activity revealed by antibacterial screening highlights the importance of employing a multi-pronged approach for AMP discovery. Further, this study demonstrates that flax, red clover, and sesame are promising sources for further AMP discovery and characterization.

Sanguiins—Promising Molecules with Broad Biological Potential

Compounds of natural origin, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovering new medicines. In this review, we summarize the naturally occurring ellagitannins, sanguiins, which are bioactive constituents of various traditional medicinal plants, especially from the Rosaceae family. In-depth studies of sanguiin H-6 as an antimicrobial, antiviral, anticancer, anti-inflammatory, and osteoclastogenesis inhibitory agent have led to potent drug candidates. In addition, recently, virtual screening studies have suggested that sanguiin H-6 might increase resistance toward SARS-CoV-2 in the early stages of infection. Further experimental investigations on ADMET (absorption, distribution, metabolism, excretion, and toxicity) supplemented with molecular docking and molecular dynamics simulation are still needed to fully understand sanguiins’ mechanism of action. In sum, sanguiins appear to be promising compounds for additional studies, especially for their application in therapies for a multitude of common and debilitating ailments.

Estimation and evaluation of medicinal efficacy of maximum inhibitory concentration of alkaloids extracted from Iraqi Cordia myxa leaves against some pathogenic bacteria

Cordia myxa is considered as one of traditional medicinal plants abundant in many countries including Iraq. Because of the healthy importance of this plant therefore the current research was established to extract the alkaloids from the its leaves with extraction percentage equal to 5.8% Preliminary qualitative detections were achieved for the alkaloids by using various chemical reagents. The medicinal efficacy of these alkaloids was determined depending on maximum inhibitory concentration (Max IC) which has value equal to 150 mg/ml and this concentration recorded inhibition zone diameters values equal to 30,22,26,25 and 30 mm against Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Proteus Sp. and klebsiella Sp. bacteria. So Cordia myxa leaves alkaloids can be used as natural chemical drug to treat the most infections and inflammatory caused by these pathogens.

review on traditional medicinal plants with ant diabetic properties

In children following asthma and epilepsy, diabetes is the third most prevalent chronic condition. More recently, the cumulative incidence of diabetes has started to grow significantly among children and adults. This has been partly influenced by the obesity pandemic in youth. Understandably, the health agencies and countries coping with the disease's important morbidity with possible grave complications have been placing an economic strain. More treatment discoveries have since broadened the list of alternatives for the drugs available. The use of plants to treat different human conditions is stated in Ayurveda and other Indian literature. India has approximately 48000 plant species and several thousand of them have claimed to have medicinal properties. Ants diabetic properties have been seen in research on plants described or historically used in ancient literature in the last few decades. The area of herbal medicine has grown exponentially in recent years, and both in the development and developed countries these medications are increasingly common due to their natural sources and fewer side effects. This study is aimed to provide information about the plant's anti-diabetes function based on the main evidence gathered from web search pages from different literature and science publications.