Orthopedia Homeobox Protein (OTP)

2021 ◽  
pp. 1-2
Author(s):  
Stefano La Rosa
Keyword(s):  
Homeobox Protein

scholarly journals Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating β-catenin

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Anqi Xu ◽  
Xizhao Wang ◽  
Jie Luo ◽  
Mingfeng Zhou ◽  
Renhui Yi ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Tumor Grade ◽  
Prognostic Indicator ◽  
Migration And Invasion ◽  
Poor Overall Survival ◽  
Mesenchymal Transition ◽  
Kaplan Meier ◽  
Homeobox Protein

AbstractThe homeobox protein cut-like 1 (CUX1) comprises three isoforms and has been shown to be involved in the development of various types of malignancies. However, the expression and role of the CUX1 isoforms in glioma remain unclear. Herein, we first identified that P75CUX1 isoform exhibited consistent expression among three isoforms in glioma with specifically designed antibodies to identify all CUX1 isoforms. Moreover, a significantly higher expression of P75CUX1 was found in glioma compared with non-tumor brain (NB) tissues, analyzed with western blot and immunohistochemistry, and the expression level of P75CUX1 was positively associated with tumor grade. In addition, Kaplan–Meier survival analysis indicated that P75CUX1 could serve as an independent prognostic indicator to identify glioma patients with poor overall survival. Furthermore, CUX1 knockdown suppressed migration and invasion of glioma cells both in vitro and in vivo. Mechanistically, this study found that P75CUX1 regulated epithelial–mesenchymal transition (EMT) process mediated via β-catenin, and CUX1/β-catenin/EMT is a novel signaling cascade mediating the infiltration of glioma. Besides, CUX1 was verified to promote the progression of glioma via multiple other signaling pathways, such as Hippo and PI3K/AKT. In conclusion, we suggested that P75CUX1 could serve as a potential prognostic indicator as well as a novel treatment target in malignant glioma.

scholarly journals Epistatic Rescue of Nkx2.5 Adult Cardiac Conduction Disease Phenotypes by Prospero-Related Homeobox Protein 1 and HDAC3

2012 ◽  
Vol 111 (2) ◽  
Author(s):  
Catherine A. Risebro ◽  
Louisa K. Petchey ◽  
Nicola Smart ◽  
John Gomes ◽  
James Clark ◽  
...  
Keyword(s):  
Cardiac Conduction ◽  
Disease Phenotypes ◽  
Homeobox Protein

scholarly journals Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma

2011 ◽  
Vol 105 (4) ◽  
pp. 565-574 ◽  
Author(s):  
G Gremel ◽  
D Ryan ◽  
M Rafferty ◽  
F Lanigan ◽  
S Hegarty ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Prognostic Relevance ◽  
Homeobox Protein

scholarly journals Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach

Oncogene ◽  
2007 ◽  
Vol 26 (31) ◽  
pp. 4600-4608 ◽  
Author(s):  
S Tomida ◽  
K Yanagisawa ◽  
K Koshikawa ◽  
Y Yatabe ◽  
T Mitsudomi ◽  
...  
Keyword(s):  
Homeobox Protein

Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5

Development ◽  
1999 ◽  
Vol 126 (17) ◽  
pp. 3795-3809 ◽  
Author(s):  
D. Acampora ◽  
G.R. Merlo ◽  
L. Paleari ◽  
B. Zerega ◽  
M.P. Postiglione ◽  
...  
Keyword(s):  
Developmental Stages ◽  
Brain Regions ◽  
Lacz Gene ◽  
Vestibular Organ ◽  
E Coli ◽  
Branchial Arches ◽  
Homeobox Protein ◽  
Derivatives Of ◽  
Delayed Ossification ◽  
Newborn Animals

The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse embryo. In later developmental stages, it appears in the branchial arches, the otic and olfactory placodes and their derivatives, in restricted brain regions, in all extending appendages and in all developing bones. We have created a null allele of the mouse Dlx5 gene by replacing exons I and II with the E. coli lacZ gene. Heterozygous mice appear normal. Beta-galactosidase activity in Dlx5+/− embryos and newborn animals reproduces the known pattern of expression of the gene. Homozygous mutants die shortly after birth with a swollen abdomen. They present a complex phenotype characterised by craniofacial abnormalities affecting derivatives of the first four branchial arches, severe malformations of the vestibular organ, a delayed ossification of the roof of the skull and abnormal osteogenesis. No obvious defect was observed in the patterning of limbs and other appendages. The defects observed in Dlx5−/− mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation.

GHF-1, a Tissue-Specific Transcription Factor, is a Homeobox Protein

1989 ◽  
pp. 90-109
Author(s):  
José-Luis Castrillo ◽  
Lars E. Theill ◽  
Mordechai Bodner ◽  
Michael Karin
Keyword(s):  
Transcription Factor ◽  
Tissue Specific ◽  
Specific Transcription Factor ◽  
Homeobox Protein
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