Many geologists assign most of large- and medium-sized massive sulfide polymetallic ore deposits of Eastern Kazakhstan to the VMS type. These ore deposits formed in the Devonian, under conditions of rifting and active basalt-andesite-rhyolite volcanism. Ore bodies of these deposits are noted to be clearly confined to formations of several geochronologic levels (D1e to D3fm). Hydrothermal-sedimentary syngenetic and hydrothermal-metasomatic ores are distinguished. High concentrations of base metals in the ores (above 10 % sum metals) and their rather simple mineral composition (chalcopyrite, pyrite, galena, and sphalerite) are a characteristic feature of all the massive sulfide polymetallic ore deposits of Rudny Altai. The ores are noted to be multicomponental, with elevated contents of the admixtures of precious metals and rare elements (Cd, Se, Bi, Te, Ta, W, etc.). Mineralogical investigations of the ores have demonstrated an intricate relationships of the major ore minerals (chalcopyrite, pyrite, sphalerite, galena) that exhibit several generations and different geochemical specialization. Minerals of Au, Ag, Te, Bi, and other elements are encountered as individual grains or microscopic inclusions and stringers in minerals of Cu, Pb, and Zn. A significant vertical range of the ore mineralization (more than 100 m), the complexity and long duration of the ore-forming processes, the clearly defined confinement of the ore mineralization to certain geochronologic levels, – all these allow us to suppose a possibility of discovery of new ore lodes or individual ore deposits within the already known ore fields of the Kazakhstan segment of Rudny Altai