The Crucial Relevance of ALA and LA as Primary Peroxisomal Beta-Oxidation Substrates, of Oxidised LA as the Primary Endogenous Activator of PPAR Gamma, and Energy Deficit as the Primary Activator of PPAR Alpha

2016 ◽  
pp. 451-463
Author(s):  
Robert Andrew Brown
Keyword(s):  
Ppar Gamma ◽  
Energy Deficit ◽  
Beta Oxidation ◽  
Ppar Alpha ◽  
Oxidation Substrates

Impact of Interaction Between PPAR Alpha and PPAR Gamma on Breast Cancer Risk in the Chinese Han Population

2017 ◽  
Vol 17 (5) ◽  
pp. 336-340 ◽  
Author(s):  
Xiong Lianggeng ◽  
Liang Baiwu ◽  
Bai Maoshu ◽  
Liu Jiming ◽  
Li Youshan
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Ppar Gamma ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Ppar Alpha ◽  
Han Population

scholarly journals Association of PPAR Alpha Intron 7 G/C, PPAR Gamma 2 Pro12Ala, and C161T Polymorphisms with Serum Fetuin-A Concentrations

PPAR Research ◽  
2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Bernadett Márkus ◽  
Krisztián Vörös ◽  
Dorina Supák ◽  
Zsolt Melczer ◽  
Károly Cseh ◽  
...  
Keyword(s):  
Fragment Length Polymorphism ◽  
Ppar Gamma ◽  
Multiple Regression Model ◽  
Chain Reaction ◽  
Ppar Alpha ◽  
Fetuin A ◽  
Activator Proteins ◽  
Allele Variant ◽  
Polymerase Chain ◽  
Restriction Fragment Length

Background. Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. Aims. We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. Patients and Methods. The PPARα intron 7 G/C polymorphism was studied in cohort 1 (79 reference individuals, 165 postinfarction patients). The two PPARγ polymorphisms were investigated in cohort 2 (162 reference individuals, 165 postinfarction patients). Fetuin-A levels and PPAR polymorphisms were determined by radial immunodiffusion and polymerase chain reaction-restriction fragment length polymorphism techniques. Results. The C allele variant of PPARα intron 7 G2467C was associated with higher fetuin-A levels (p=0.018). Postinfarction status (p=0.001), PPARα intron 7 GG/GC/CC genotypes (p=0.032), and the C allele (p=0.021) were the strongest determinants of fetuin-A concentration in a multiple regression model. Higher fetuin-A levels were associated with the Pro variant of PPARγ2 (p=0.047). Postinfarction status (p=0.041) and BMI (p<0.001) but not PPARγ2 Pro were the strongest determinants of fetuin-A concentrations. PPARγ exon 6 C161T genotypes were not associated with fetuin-A levels. Conclusions. Fetuin-A was determined mainly by the PPARα intron 7C allele and postinfarction status in cohort 1 and the BMI and postinfarction in cohort 2. The PPARα intron 7C and PPARγ2 Pro variants are associated with fetuin-A levels.

Differential modulation of CXCL8 versus CXCL10, by cytokines, PPAR-gamma, or PPAR-alpha agonists, in primary cells from Graves' disease and ophthalmopathy

2019 ◽  
Vol 18 (7) ◽  
pp. 673-678 ◽  
Author(s):  
Silvia Martina Ferrari ◽  
Francesca Ragusa ◽  
Sabrina Rosaria Paparo ◽  
Francesco Nasini ◽  
Marco Nardi ◽  
...  
Keyword(s):  
Ppar Gamma ◽  
Graves Disease ◽  
Primary Cells ◽  
Differential Modulation ◽  
Ppar Alpha

Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma

2007 ◽  
Vol 561 (1-3) ◽  
pp. 194-201 ◽  
Author(s):  
Antônio Carlos P. Oliveira ◽  
Caryne M. Bertollo ◽  
Leonardo Tadeu S. Rocha ◽  
Elias B. Nascimento ◽  
Karina A. Costa ◽  
...  
Keyword(s):  
Ppar Gamma ◽  
Ppar Alpha

P189 Les agonistes de PPAR gamma et de PPAR alpha induisent la conversion d’adipocytes blancs humains en adipocytes bruns et une augmentation du métabolisme des acides gras

2015 ◽  
Vol 41 ◽  
pp. A80-A81
Author(s):  
D. Beuzelin ◽  
V. Barquissau ◽  
M. Giroud ◽  
G. Béranger ◽  
A. Mairal ◽  
...  
Keyword(s):  
Ppar Gamma ◽  
Ppar Alpha ◽  
Acides Gras

30 GREEN COFFEE EXTRACT INCREASED PPAR ALPHA AND PPAR GAMMA GENE EXPRESSION IN METABOLIC SYNDROME RAT MODEL

2018 ◽  
Vol 36 ◽  
pp. e9
Author(s):  
Dwi Adi Nugroho ◽  
Mifetika Lukitasari ◽  
Mohammad Saifur Rohman
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Rat Model ◽  
Ppar Gamma ◽  
Green Coffee ◽  
Ppar Alpha
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