Antisperm Contraceptive Vaccine

2016 ◽  
pp. 249-261 ◽  
Author(s):  
Rajesh K. Naz
Reproduction ◽  
2000 ◽  
pp. 15-23 ◽  
Author(s):  
K Jewgenow ◽  
M Rohleder ◽  
I Wegner

Despite many efforts, the control of reproduction in feral cat populations is still a problem in urban regions around the world. Immunocontraception is a promising approach; thus the present study examined the suitability of the widely used pig zona pellucida proteins (pZP) for contraception in feral domestic cats. Purified zona pellucida proteins obtained from pig and cat ovaries were used to produce highly specific antisera in rabbits. Antibodies against pZP raised in rabbits or lions were not effective inhibitors of either in vitro sperm binding (cat spermatozoa to cat oocytes) or in vitro fertilization in cats, whereas antibodies against feline zona pellucida proteins (fZP) raised in rabbits showed a dose-dependent inhibition of in vitro fertilization. Immunoelectrophoresis, ELISA and immunohistology of ovaries confirmed these results, showing crossreactivity of anti-fZP sera to fZP and to a lesser extent to pZP, but no interaction of anti-pZP sera with fZP. It is concluded that cat and pig zonae pellucidae express a very small number of shared antigenic determinants, making the use of pZP vaccine in cats questionable. A contraceptive vaccine based on feline zona pellucida determinants will be a better choice for the control of reproduction in feral cats if immunogenity can be achieved.


1995 ◽  
Vol 7 (4) ◽  
pp. 825 ◽  
Author(s):  
LE Kerr

The development of novel forms of contraception is one way in which the world population crisis is being tackled. The concept of a contraceptive vaccine based on gamete-specific antigens is a particularly attractive approach. Much research has been carried out to identify sperm antigens which could be used as the immunogen. The most encouraging leads have come from groups using monoclonal antibodies to identify and characterize sperm antigens important for fertility (e.g. SP-10, PH-20 and PH-30). Identification of these molecules will also enable the development of specific tests for the diagnosis of immune infertility.


PEDIATRICS ◽  
1991 ◽  
Vol 88 (3) ◽  
pp. A102-A102

The U.S. has fallen behind other countries in developing contraceptives, depriving Americans of birth control choices available elsewhere, a study by the Institute of Medicine reports. All but one of the major pharmaceutical companies in the U.S. have stopped significant contraceptive research, and new birth control techniques used overseas haven't been cleared for the U.S. market... There are a number of promising contraceptive developments on the horizon, some of which already are in use outside the U.S. These include a contraceptive vaccine, reversible male and female sterilization procedures, long-lasting contraceptives that can be implanted under a woman's skin, new spermicides that help reduce the risk of venereal disease, and new male contraceptives that interfere with the production of sperm. But without new spending on research and a different regulatory climate, Americans will continue to depend on 20-year-old birth control technology, said Luigi Mastroianni Jr., the committee's chairman.


Author(s):  
G.P. TALWAR ◽  
S.K. GUPTA ◽  
O. SINGH ◽  
V. SINGH ◽  
C. DAS

2013 ◽  
Vol 69 (5) ◽  
pp. 495-508 ◽  
Author(s):  
Shipra Goyal ◽  
Boomi Manivannan ◽  
Ganesh R. Kumraj ◽  
Abdul S. Ansari ◽  
Nirmal K. Lohiya

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