Pathogenesis of Insulin Resistance and Glucose Intolerance in Childhood Obesity

2017 ◽  
pp. 379-391 ◽  
Author(s):  
Ram Weiss ◽  
Emilia Hagman
Keyword(s):  
Insulin Resistance ◽  
Childhood Obesity ◽  
Glucose Intolerance

Female 5[beta]-reductase knockout mice are protected from diet induced obesity, insulin resistance and glucose intolerance

2016 ◽  
Author(s):  
Laura Gathercole ◽  
Matthew Chapman ◽  
Dean Larner ◽  
Petra Klusonova ◽  
Trevor Penning ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Intolerance ◽  
Knockout Mice ◽  
Diet Induced Obesity

scholarly journals PPAR-γ2 Pro12Ala Variant, Insulin Resistance and Plasma Long-chain Polyunsaturated Fatty Acids in Childhood Obesity

2006 ◽  
Vol 60 (4) ◽  
pp. 485-489 ◽  
Author(s):  
Silvia Scaglioni ◽  
Elvira Verduci ◽  
Michela Salvioni ◽  
Maria Luisa Biondi ◽  
Giovanni Radaelli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Childhood Obesity ◽  
Polyunsaturated Fatty Acids ◽  
Long Chain

Diet quality and periodontal disease: Results from the oral infections, glucose intolerance and insulin resistance study (ORIGINS)

2021 ◽  
Vol 48 (5) ◽  
pp. 638-647
Author(s):  
Francesco DeMayo ◽  
Rebecca Molinsky ◽  
Muna J. Tahir ◽  
Sumith Roy ◽  
Jeanine M. Genkinger ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Periodontal Disease ◽  
Glucose Intolerance ◽  
Diet Quality ◽  
Oral Infections

scholarly journals Increased Tumor Growth in Mice with Diet-Induced Obesity: Impact of Ovarian Hormones

Endocrinology ◽  
2006 ◽  
Vol 147 (12) ◽  
pp. 5826-5834 ◽  
Author(s):  
Shoshana Yakar ◽  
Nomeli P. Nunez ◽  
Patricia Pennisi ◽  
Pnina Brodt ◽  
Hui Sun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Tumor Growth ◽  
Glucose Intolerance ◽  
Tumor Development ◽  
Tumor Growth Rate ◽  
Obese Mice ◽  
Female Mice ◽  
Diet Induced Obesity ◽  
Body Adiposity ◽  
Obese Female

Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

scholarly journals Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance

2009 ◽  
Vol 285 (9) ◽  
pp. 6198-6207 ◽  
Author(s):  
Béatrice Bailly-Maitre ◽  
Bengt F. Belgardt ◽  
Sabine D. Jordan ◽  
Beatrice Coornaert ◽  
Miriam John von Freyend ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Intolerance
Sign in / Sign up

Export Citation Format

Share Document