Multi-label Whole Heart Segmentation Using CNNs and Anatomical Label Configurations

Author(s):  
Christian Payer ◽  
Darko Štern ◽  
Horst Bischof ◽  
Martin Urschler
Keyword(s):  
2019 ◽  
Vol 82 (4) ◽  
pp. 1331-1342 ◽  
Author(s):  
Haikun Qi ◽  
Olivier Jaubert ◽  
Aurelien Bustin ◽  
Gastao Cruz ◽  
Huijun Chen ◽  
...  

2021 ◽  
Vol 1769 (1) ◽  
pp. 012016
Author(s):  
Kening Le ◽  
Zeyu Lou ◽  
Weiliang Huo ◽  
Xiaolin Tian
Keyword(s):  

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
P Poskaite ◽  
M Pamminger ◽  
C Kranewitter ◽  
C Kremser ◽  
M Reindl ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: None. Background The natural history of thoracic aortic aneurysm (TAA) is one of progressive expansion. Asymptomatic patients who do not meet criteria for repair require conservative management including ongoing aneurysm surveillance, mostly carried out by contrast-enhanced computed tomography angiography (CTA). Purpose To prospectively compare image quality and reliability of a prototype non-contrast, self-navigated 3D whole-heart magnetic resonance angiography (MRA) with contrast-enhanced computed tomography angiography (CTA) for sizing of thoracic aortic aneurysm (TAA). Methods Self-navigated 3D whole-heart 1.5 T MRA was performed in 20 patients (aged 67 ± 8.6 years, 75% male) for sizing of TAA; a subgroup of 18 (90%) patients underwent additional contrast-enhanced CTA on the same day. Subjective image quality was scored according to a 4-point Likert scale and ratings between observers were compared by Cohen’s Kappa statistics. Continuous MRA and CTA measurements were analyzed with regression and Bland-Altman analysis. Results Overall subjective image quality as rated by two observers was 1 [interquartile range (IQR) 1-2] for self-navigated MRA and 1.5 [IQR 1-2] for CTA (p = 0.717). For MRA a perfect inter-observer agreement was found for presence of artefacts and subjective image sharpness (κ=1). Subjective signal inhomogeneity correlated highly with objectively quantified inhomogeneity of the blood pool signal (r = 0.78-0.824, all p <0.0001). Maximum diameters of TAA as measured by self-navigated MRA and CTA showed excellent correlation (r = 0.997, p < 0.0001) without significant inter-method bias (bias -0.0278, lower and upper limit of agreement -0.74 and 0.68, p = 0.749). Inter- and intraobserver correlation of aortic aneurysm as measured by MRA was excellent (r = 0.963 and 0.967, respectively) without significant bias (all p ≤ 0.05). Conclusion Self-navigated 3D whole-heart MRA enables reliable contrast- and radiation free aortic dilation surveillance without significant difference to standardized CTA while providing predictable acquisition time and by offering excellent image quality. Abstract Figure.


2021 ◽  
Vol 11 (4) ◽  
pp. 1965
Author(s):  
Raul-Ronald Galea ◽  
Laura Diosan ◽  
Anca Andreica ◽  
Loredana Popa ◽  
Simona Manole ◽  
...  

Despite the promising results obtained by deep learning methods in the field of medical image segmentation, lack of sufficient data always hinders performance to a certain degree. In this work, we explore the feasibility of applying deep learning methods on a pilot dataset. We present a simple and practical approach to perform segmentation in a 2D, slice-by-slice manner, based on region of interest (ROI) localization, applying an optimized training regime to improve segmentation performance from regions of interest. We start from two popular segmentation networks, the preferred model for medical segmentation, U-Net, and a general-purpose model, DeepLabV3+. Furthermore, we show that ensembling of these two fundamentally different architectures brings constant benefits by testing our approach on two different datasets, the publicly available ACDC challenge, and the imATFIB dataset from our in-house conducted clinical study. Results on the imATFIB dataset show that the proposed approach performs well with the provided training volumes, achieving an average Dice Similarity Coefficient of the whole heart of 89.89% on the validation set. Moreover, our algorithm achieved a mean Dice value of 91.87% on the ACDC validation, being comparable to the second best-performing approach on the challenge. Our approach provides an opportunity to serve as a building block of a computer-aided diagnostic system in a clinical setting.


2019 ◽  
Vol 83 (1) ◽  
pp. 178-187 ◽  
Author(s):  
Giovanna Nordio ◽  
Torben Schneider ◽  
Gastao Cruz ◽  
Teresa Correia ◽  
Aurelien Bustin ◽  
...  

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 548 ◽  
Author(s):  
Helene Juul Belling ◽  
Wolfgang Hofmeister ◽  
Ditte Caroline Andersen

Myocardial infarction (MI) is a worldwide condition that affects millions of people. This is mainly caused by the adult human heart lacking the ability to regenerate upon injury, whereas zebrafish have the capacity through cardiomyocyte proliferation to fully regenerate the heart following injury such as apex resection (AR). But a systematic overview of the methods used to evidence heart regrowth and regeneration in the zebrafish is lacking. Herein, we conducted a systematical search in Embase and Pubmed for studies on heart regeneration in the zebrafish following injury and identified 47 AR studies meeting the inclusion criteria. Overall, three different methods were used to assess heart regeneration in zebrafish AR hearts. 45 out of 47 studies performed qualitative (37) and quantitative (8) histology, whereas immunohistochemistry for various cell cycle markers combined with cardiomyocyte specific proteins was used in 34 out of 47 studies to determine cardiomyocyte proliferation qualitatively (6 studies) or quantitatively (28 studies). For both methods, analysis was based on selected heart sections and not the whole heart, which may bias interpretations. Likewise, interstudy comparison of reported cardiomyocyte proliferation indexes seems complicated by distinct study designs and reporting manners. Finally, six studies performed functional analysis to determine heart function, a hallmark of human heart injury after MI. In conclusion, our data implies that future studies should consider more quantitative methods eventually taking the 3D of the zebrafish heart into consideration when evidencing myocardial regrowth after AR. Furthermore, standardized guidelines for reporting cardiomyocyte proliferation and sham surgery details may be considered to enable inter study comparisons and robustly determine the effect of given genes on the process of heart regeneration.


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