Targeted Therapeutic Nanoparticles for Cancer and Other Human Diseases

Nanotechnology: Applications in Energy, Drug and Food ◽

10.1007/978-3-319-99602-8_8 ◽

2018 ◽

pp. 187-207

Author(s):

Rabiatul Basria S. M. N. Mydin ◽

Wan Nordiana Rahman ◽

Rosmazihana Mat Lazim ◽

Amirah Mohd Gazzali ◽

Nur Hazirah Mohd Azlan ◽

...

Keyword(s):

Human Diseases ◽

Targeted Therapeutic

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NLRP3 Inflammasome and Inflammatory Diseases

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/4063562 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11 ◽

Cited By ~ 11

Author(s):

Zheng Wang ◽

Simei Zhang ◽

Ying Xiao ◽

Wunai Zhang ◽

Shuai Wu ◽

...

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammatory Diseases ◽

Deep Understanding ◽

Vital Role ◽

Human Diseases ◽

Therapeutic Approaches ◽

Proinflammatory Role ◽

Almost All ◽

Targeted Therapeutic

Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.

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Experimental Amyloidosis Induced by Immune Complex

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066978 ◽

1971 ◽

Vol 29 ◽

pp. 582-583

Author(s):

A. Kawaoi

Keyword(s):

Immune Complex ◽

Systemic Amyloidosis ◽

Human Diseases ◽

Experimental Amyloidosis ◽

Freund’S Complete Adjuvant ◽

Freund's Complete Adjuvant ◽

Immunological Approach ◽

Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

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