Maternal Deprivation Model

Author(s):  
Michael M. Morgan ◽  
MacDonald J. Christie ◽  
Thomas Steckler ◽  
Ben J. Harrison ◽  
Christos Pantelis ◽  
...  
2020 ◽  
Vol 38 ◽  
pp. 74-82
Author(s):  
Gabriel Olaiya Omotoso ◽  
Fatimah Adeola Abdulsalam ◽  
Nafisat Yetunde Mutholib ◽  
Abdulkabir I. Bature ◽  
Ismail Temitayo Gbadamosi

2020 ◽  
Author(s):  
Gabriel Olaiya Omotoso ◽  
Fatimah Adeola Abdulsalam ◽  
Nafisat Yetunde Mutholib ◽  
Abdulkabir Bature ◽  
Ismail Temitayo Gbadamosi

ABSTRACTMaternal deprivation (MD) during early life development has been documented to culminate in long-term alterations in brain function and behavioural manifestations that mimic schizophrenia. This study elucidated the putative neuroprotective roles of vitamin B complex in MD-induced behavioural and neurochemical modifications in hippocampus and prefrontal cortex of Wistar rats. Rat pups were maternally deprived on postnatal day 9 for 24 hours and then treated with or without vitamin B complex for 15 days while a control group was undisturbed during the experimental period. The rats were then subjected to behavioural paradigms to measure memory indices and anxiety levels. The rats were sacrificed to obtain the PFC and hippocampus for histomorphological and biochemical analysis. Behavioural analysis of the animals revealed that MD induced a declination in long- and short-term memory in addition to anxiety-like behaviour in the open field test. Cortico-hippocampal histomorphology of these animals showed an increased astrocytic density and chromatolysis, which were accompanied by reduced levels of superoxide dismutase and catalase enzymes. Vitamin B complex mitigated MD-induced behavioural decline, histomorphological perturbation and oxidative stress by enhancing the intrinsic antioxidant defence, thereby culminating in nootropic behaviour and reduced anxiety. In conclusion, we confirmed the hypothesis that vitamin B complex is neuroprotective against neuropathological alterations induced by maternal deprivation.


2001 ◽  
Vol 120 (5) ◽  
pp. A715-A715
Author(s):  
A ROSZTOCZY ◽  
S BRADESI ◽  
C BEAUFRAND ◽  
J FIORAMONTI ◽  
T WITTMANN ◽  
...  

Author(s):  
Jasmine Thombs

This vignette illustrates how an individual with a complex pathology can present with a sight-threatening condition that appears to resist medical treatment in some measure if the psychological component is ignored. The case exemplifies the way in which therapeutic intervention can help in the recovery from a sightthreatening condition and from the underlying trauma associated with it. It is recognised that people affected by sight-threatening conditions will understandably experience very strong and at times overwhelming feelings related to grief and loss. In this case, the possibility of sight loss created a severe reaction of panic and confusion, and disrupted cognitive functions. These problems were often compounded by symptoms including anger, disassociation, apathy, and depression. This vignette showed how Bowlby's concepts of attachment and loss, and maternal deprivation, helped in the therapeutic alliance. The understanding of the client's internal working model was fundamental to the ongoing therapeutic process that allowed her to heal.


2014 ◽  
Vol 11 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Samira Valvassori ◽  
Roger Varela ◽  
Camila Arent ◽  
Gustavo Dal-Pont ◽  
Tamara Bobsin ◽  
...  

2021 ◽  
pp. 113494
Author(s):  
Claire Toinon ◽  
Susanne Waiblinger ◽  
Jean-Loup Rault

2021 ◽  
Vol 169 ◽  
pp. 128-135
Author(s):  
Hossein Masrouri ◽  
Maryam Azadi ◽  
Saeed Semnanian ◽  
Hossein Azizi

2021 ◽  
pp. 107479
Author(s):  
Xiaofan Xiong ◽  
Lin Han ◽  
Meiyang Fan ◽  
Lingyu Zhang ◽  
Liying Liu ◽  
...  

Life Sciences ◽  
1979 ◽  
Vol 25 (24-25) ◽  
pp. 2089-2097 ◽  
Author(s):  
Cynthia M. Kuhn ◽  
Gary Evoniuk ◽  
Saul M. Schanberg

Sign in / Sign up

Export Citation Format

Share Document