This paper presents a novel fast Fourier transform (FFT)-based exhaustive search method extended to off-grid translational and rotational degrees of freedom. The method combines the advantages of the FFT-based exhaustive search, which samples all the conformations of a system under study on a grid, with a local optimization technique that guarantees to find the nearest optimal off-grid conformation. The method is demonstrated on a fitting problem and can be readily applied to a docking problem. The algorithm first samples a scoring function on a six-dimensional grid of sizeN6using the FFT. This operation has an asymptotic complexity ofO(N6logN). Then, the method performs the off-grid search using a local quadratic approximation of the cost function and the trust-region optimization algorithm. The computation of the quadratic approximation is also accelerated by FFT at the same additional asymptotic cost ofO(N6logN). The method is demonstrated by fitting atomic protein models into several simulated and experimental maps from cryo-electron microscopy. The method is available at https://team.inria.fr/nano-d/software/offgridfit.
Research evaluating the relationship between lactose intolerance (LI) symptoms and age, gender and race is reviewed. An exhaustive search was conducted on the Google Scholar and PubMed databases. The evidence suggests that women, the elderly or specific racial groups are not more susceptible to LI, but rather dose, body size and genetic differences in lactase non-persistence (LNP) are the primary drivers of intolerance symptoms.
Abstract
We show how to build a binary matrix from the MRHS representation of a symmetric-key cipher. The matrix contains the cipher represented as an equation system and can be used to assess a cipher’s resistance against algebraic attacks. We give an algorithm for solving the system and compute its complexity. The complexity is normally close to exhaustive search on the variables representing the user-selected key. Finally, we show that for some variants of LowMC, the joined MRHS matrix representation can be used to speed up regular encryption in addition to exhaustive key search.
Ternary quarter wavelength coatings for gravitational wave detector mirrors: Design optimization via exhaustive search