Finding Compact Structural Motifs

2007 ◽  
pp. 142-149 ◽  
Author(s):  
Jianbo Qian ◽  
Shuai Cheng Li ◽  
Dongbo Bu ◽  
Ming Li ◽  
Jinbo Xu
Keyword(s):  
Structural Motifs

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

scholarly journals Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein

2020 ◽  
Vol 432 (4) ◽  
pp. 1048-1063 ◽  
Author(s):  
Tossapol Pholcharee ◽  
David Oyen ◽  
Jonathan L. Torres ◽  
Yevel Flores-Garcia ◽  
Gregory M. Martin ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antibody Responses ◽  
Circumsporozoite Protein ◽  
Structural Motifs

Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs

2021 ◽  
Vol 86 (3) ◽  
pp. 2499-2521
Author(s):  
K. C. Nicolaou ◽  
Santhosh Reddy Rekula ◽  
S. Mothish Kumar ◽  
Ananda Rao Podilapu ◽  
Ryan P. Matuszak ◽  
...  
Keyword(s):  
Biological Investigation ◽  
Structural Motifs ◽  
Design Synthesis

scholarly journals Structural motifs and intramolecular interactions in non-canonical G-quadruplexes

2021 ◽  
Author(s):  
Jagannath Jana ◽  
Swantje Mohr ◽  
Yoanes Maria Vianney ◽  
Klaus Weisz
Keyword(s):  
Nucleic Acid ◽  
Structural Features ◽  
Intramolecular Interactions ◽  
Structural Motifs ◽  
Nucleic Acid Sequences

G-rich nucleic acid sequences encompassing G-tracts of varying lengths can fold into different non-canonical G-quadruplexes with distinct structural features.

Defects in Graphene Oxide as Structural Motifs

ChemNanoMat ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 244-252 ◽  
Author(s):  
Patrick Feicht ◽  
Siegfried Eigler
Keyword(s):  
Graphene Oxide ◽  
Structural Motifs

scholarly journals Scandium calix[n]arenes (n = 4, 6, 8): Structural, cytotoxicity and ring opening polymerization studies.

2021 ◽  
Author(s):  
Abdullah F. Alshamrani ◽  
Orlando Santoro ◽  
Timothy J. Prior ◽  
"Mohammed A Alamri ◽  
Graeme J Stasiuk ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Structural Motifs

Interaction of [Sc(OR)3] (R = iPr or triflate) with p-tert-butylcalix[n]arenes, where n = 4, 6, or 8, affords a number of intriguing structural motifs, which are relatively non-toxic (cytotoxicity evaluated...

scholarly journals RNA 3-dimensional structural motifs as a critical constraint of viroid RNA evolution

2018 ◽  
Vol 14 (2) ◽  
pp. e1006801 ◽  
Author(s):  
Ying Wang ◽  
Craig L. Zirbel ◽  
Neocles B. Leontis ◽  
Biao Ding
Keyword(s):  
Structural Motifs ◽  
3 Dimensional ◽  
Rna Evolution
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