Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

A REVIEW ON RECENT ADVANCES IN CHEMISTRY, SYNTHESIS AND BIOLOGICAL APPLICATIONS OF ISATIN DERIVATIVES

2018 ◽  
pp. 16-22
Author(s):  
Shukla PK ◽  
Singh MP ◽  
Patel R
Keyword(s):  
Heterocyclic Compounds ◽  
Biologically Active ◽  
Biological Applications ◽  
Plant Origin ◽  
Recent Past ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Biological Aspects ◽  
Isatin Derivatives

Indole and its derivatives have engaged a unique place in the chemistry of nitrogen heterocyclic compounds. The recognition of the plant growthhormone, heteroauxin, the significant amino acids, tryptamine & tryptophan and anti-inflammatory drug, indomethacine are the imperativederivatives of indole which have added stimulus to this review work. Isatin (1H-indole-2,3-dione), an indole derivative of plant origin. Althoughit is a naturally occurring compound, but was synthesized by Erdmann and Laurent in 1840 before it was found in nature. Isatin is a versatileprecursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. It is concernedin many pharmacological activities like anti-malarial, antiviral, anti-allergic, antimicrobial etc; isatin and its derivatives have been also found todemonstrate promising outcomes against various cancer cell lines. This review provides a brief overview on the recent advances and futureperspectives on chemistry and biological aspects of isatin and its derivatives reported in the recent past.

Approaches for the synthesis, chemical modification and biological properties of N-acylphenothiazines

2021 ◽  
Vol 10 (4) ◽  
pp. 377-392 ◽  
Author(s):  
Iryna Myrko ◽  
Taras Chaban ◽  
Yulia Matiichuk ◽  
Mohammad Arshad ◽  
Vasyl Matiychuk
Keyword(s):  
Experimental Data ◽  
Chemical Modification ◽  
Medicinal Chemistry ◽  
Biological Properties ◽  
Chemotherapeutic Agents ◽  
Present Review ◽  
The Novel ◽  
Pharmacological Activities ◽  
The Past ◽  
Biological Potential

In this review we systematized the theoretical and experimental data concerning the versatile approaches for the synthesis of N-acylphenothiazines. The aim of the study was to compile the literature reported worldwide in the past 20 years. This article also reviewed the analysis of pharmacological activities of these heterocycles as one of the promising chemotherapeutic objects for the modern bioorganic and medicinal chemistry. It has been hypothesized that the enormous biological potential of these moieties is due to the radical nature in the acyl moiety. Therefore, the present review will be a good contribution to the literature and will provide the platform for the medicinal chemistry researchers to carry out more studies aiming the N-acylphenothiazine moieties as the novel chemotherapeutic agents.

scholarly journals Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo
Keyword(s):  
Drug Delivery ◽  
Sialic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

scholarly journals Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives

2021 ◽  
Vol 17 ◽  
pp. 2462-2476
Author(s):  
Yi Liu ◽  
Puying Luo ◽  
Yang Fu ◽  
Tianxin Hao ◽  
Xuan Liu ◽  
...  
Keyword(s):  
Reaction Mechanisms ◽  
Structural Motifs ◽  
Pyrrole Derivatives ◽  
The Past ◽  
Recent Advances ◽  
Functionalized Pyridine ◽  
Great Progress ◽  
Made In

Great progress has been made in the tandem annulation of enynes in the past few years. This review only presents the corresponding reactions of 1,3-enyne structural motifs to provide the functionalized pyridine and pyrrole derivatives. The functionalization reactions cover iodination, bromination, trifluoromethylation, azidation, carbonylation, arylation, alkylation, selenylation, sulfenylation, amidation, esterification, and hydroxylation. We also briefly introduce the applications of the products and the reaction mechanisms for the synthesis of corresponding N-heterocycles.

scholarly journals Recent Advances in Chalcones: Synthesis, Transformation and Pharmacological Activities

2019 ◽  
pp. 1-16
Author(s):  
Oluwaseyi Bukky Ovonramwen ◽  
Bodunde Joseph Owolabi ◽  
Amowie Philip Oviawe
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compound ◽  
Heterocyclic Compounds ◽  
Condensation Reaction ◽  
Review Article ◽  
Pharmacological Activities ◽  
Usual Approach ◽  
Recent Advances ◽  
Anti Cancer ◽  
Multifunctional Molecules

Chalcones are useful intermediates in the synthesis of heterocyclic compound and the unique reagents in organic synthesis. The usual approach to obtain chalcones is through Claisen-Schmidt condensation. Several novel heterocyclic chalcone analogs have emerged. Chalcones are multifunctional molecules that possess promising pharmacological activities. Chalcones are known for anti-cancer, antioxidant, anti-inflammatory, anti-microbial, anti-tubercular, antileishmanial, antimalarial, anthelmintic, osteogenic activities. This review article focuses on recent applications of Claisen-Schmidt condensation reaction employed in the synthesis of chalcone, its transformation to heterocyclic compounds and pharmacological activities.

scholarly journals Recent Advances in the Pharmacological Activities of Dioscin

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Longfei Yang ◽  
Shengnan Ren ◽  
Fei Xu ◽  
Zhiming Ma ◽  
Xin Liu ◽  
...  
Keyword(s):  
Pharmacological Activities ◽  
Protective Properties ◽  
The Past ◽  
Recent Advances ◽  
Clinical Disorders ◽  
Anti Inflammatory ◽  
Potential Use

Dioscin is a typical saponin with multiple pharmacological activities. The past few years have seen an emerging interest in and growing research on this pleiotropic saponin. Here, we review the emerging pharmacological activities reported recently, with foci on its antitumor, antimicrobial, anti-inflammatory, antioxidative, and tissue-protective properties. The potential use of dioscin in therapies of diverse clinical disorders is also discussed.

scholarly journals A Review: Medicinally Important Nitrogen Sulphur Containing Heterocycles

2020 ◽  
Vol 14 (1) ◽  
pp. 49-64
Author(s):  
Praveen K. Sharma ◽  
Andleeb Amin ◽  
M. Kumar
Keyword(s):  
Broad Spectrum ◽  
Mode Of Action ◽  
Mammalian Cells ◽  
Heterocyclic Compounds ◽  
Structural Features ◽  
Present Review ◽  
Pharmacological Activities ◽  
Sulfur Heterocycles ◽  
Biological And Pharmacological Activities

Nitrogen sulphur containing heterocycles have specific properties due to which they can be used as a potential material in a different type of industries such as medicinal/pharmaceutical, paint, packing and textile, required for various chemical, physical operations and their use as products. Especially dyes, paint, agrochemicals, medicine, etc. make them more significant. In present days, Nitrogen-Sulfur heterocycles are repeatedly attracting the interest of chemists due to their exceptional bioactive behavior. The present study is a review of the work carried out by a chemist in the discovery of new, effective, medicinally important heterocyclic compounds. The present review basically focused on nitrogen-sulfur heterocycles of potential therapeutic interest, especially with thiazole, thiazine, pyrimidine, morpholine and piperazine heterosystems, benzothiazines, pyrazole-benzothiazines, morpholine-benzothiazines, piperazine-benzothiazines and pyrimidine-benzothiazoles, mainly due to their unique structural features, which enable them to exhibit a number of biological and pharmacological activities. Due to a novel mode of action, a broad spectrum of activity, lesser toxicity towards mammalian cells, and suitable profiles towards humans have triggered the use of Nitrogen Sulphur containing heterocycles in designing and synthesizing their derivatives with better properties. The overall objective of the review is to discuss the importance of novel biodynamic structurally diverse heterocycles of potential therapeutic interest: pyrimidine, morpholine, piperazine, pyrozole, benothiazoles, pyrimidobenzothiazoles, 4H-1,4-benzothiazines, pyrazolyl-benzothiazines, morpholinyl-benzothiazines and piperazinylbenzothiazines in order to have access to important commercial molecules for the search of better future.

Therapeutic Potential of Cinnoline Core: A Comprehensive Review

2020 ◽  
Vol 20 (3) ◽  
pp. 196-218
Author(s):  
Rajiv K. Tonk ◽  
Sandhya Bawa ◽  
Deepak Kumar
Keyword(s):  
Heterocyclic Compounds ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Present Review ◽  
Natural Occurrence ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Wide Range ◽  
The Family ◽  
Almost All

Cinnoline or Benzo-pyridazine has its place in the family of fairly well-known benzfuseddiazine heterocycles. Because of its natural occurrence and synthetic exploration, cinnoline compounds validated its thought-provoking bioactivity through a number of research publications and patents during last few decades. A creative consideration has been rewarded to the synthesis of cinnoline based heterocyclic compounds, mostly due to their wide range of diverse pharmacological activities. The present review covers the principle approaches to the synthesis of cinnoline nucleus and almost all biological properties of 115 cinnoline derivatives reported during the last 65 years from natural and synthetic origin with 140 references.

scholarly journals Recent Advances in the Oxone-Mediated Synthesis of Heterocyclic Compounds

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7523
Author(s):  
Helen A. Goulart ◽  
Daniela R. Araujo ◽  
Filipe Penteado ◽  
Raquel G. Jacob ◽  
Gelson Perin ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Environmentally Friendly ◽  
The Past ◽  
Recent Advances ◽  
Inorganic Species ◽  
Species Being ◽  
Potassium Peroxymonosulfate

Oxone is a commercially available oxidant, composed of a mixture of three inorganic species, being the potassium peroxymonosulfate (KHSO5) the reactive one. Over the past few decades, this cheap and environmentally friendly oxidant has become becoming a powerful tool in organic synthesis, being extensively employed to mediate the construction of a plethora of important compounds. This review summarizes the recent advances in the Oxone-mediated synthesis of N-, O- and chalcogen-containing heterocyclic compounds, through a wide diversity of reactions, starting from several kinds of substrate, highlighting the main synthetic differences, advantages, the scope and limitations.

Recent Advances in Denitrogenative Reactions of Pyridotriazoles

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3564-3576 ◽  
Author(s):  
Ilya P. Filippov ◽  
Gleb D. Titov ◽  
Nikolai V. Rostovskii
Keyword(s):  
Lewis Acids ◽  
Heterocyclic Compounds ◽  
Short Review ◽  
Diazo Compounds ◽  
Metal Compounds ◽  
The Past ◽  
Recent Advances ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Chain Isomerization

AbstractDiazo compounds display versatile reactivity and therefore are widely used in organic synthesis. Diazo compounds bearing a 2-pyridyl or a related azine moiety on the diazo carbon exist in the form of fused 1,2,3-triazoles. In this short review, we summarize the recent advances in denitrogenative reactions of [1,2,3]triazolo[1,5-a]pyridines (‘pyridotriazoles’) and related fused 1,2,3-triazoles. Over the past decade, there has been a surge of activity in this field, with novel denitrogenative reactions of pyridotriazoles induced by metal compounds, light, and Brønsted and Lewis acids having been devised. As a result, heterocyclic compounds and functionalized α-picolines as well as bio­active molecules have been synthesized. In the review, emphasis is also placed on the mechanisms of the new reactions.1 Introduction2 Ring-Chain Isomerization of Pyridotriazoles3 Metal-Catalyzed Reactions3.1 Rh(II) Catalysis3.2 Rh(III) Catalysis3.3 Cu Catalysis3.4 Pd Catalysis3.5 Catalysis by Other Metals4 Metal-Free Reactions5 Conclusion

Sign in / Sign up

Export Citation Format

Share Document