Knowledge Extraction from Microarray Datasets Using Combined Multiple Models to Predict Leukemia Types

Author(s):  
Gregor Stiglic ◽  
Nawaz Khan ◽  
Peter Kokol
2006 ◽  
Vol 3 (1) ◽  
pp. 48-55
Author(s):  
Aparesh Sood ◽  
◽  
Ankush Mittal ◽  
Divya Sarthi ◽  
◽  
...  

2001 ◽  
Vol 34 (2) ◽  
Author(s):  
Margaret Harris
Keyword(s):  

2010 ◽  
Vol 36 (9) ◽  
pp. 1295-1304 ◽  
Author(s):  
Yi-Hui ZHENG ◽  
Xin WANG ◽  
Shao-Yuan LI ◽  
Jian-Guo JIANG

2019 ◽  
Vol 13 (4) ◽  
pp. 325-333
Author(s):  
Xu Liu ◽  
Xiaoqiang Di ◽  
Jinqing Li ◽  
Huamin Yang ◽  
Ligang Cong ◽  
...  

Background: User behavior models have been widely used to simulate attack behaviors in the security domain. We revised all patents related to response to attack behavior models. How to decide the protected target against multiple models of attack behaviors is studied. Methods: We utilize one perfect rational and three bounded rational behavior models to simulate attack behaviors in cloud computing, and then investigate cloud provider’s response based on Stackelberg game. The cloud provider plays the role of defender and it is assumed to be intelligent enough to predict the attack behavior model. Based on the prediction accuracy, two schemes are built in two situations. Results: If the defender can predict the attack behavior model accurately, a single-objective game model is built to find the optimal protection strategy; otherwise, a multi-objective game model is built to find the optimal protection strategy. Conclusion: The numerical results prove that the game theoretic model performs better in the corresponding situation.


Author(s):  
Stuart Glennan

This chapter explores how mechanisms and their constituents can be classified into kinds. It argues for a weakly realist account of natural kinds—one which suggests that classification into kinds is based upon real similarities between instances of those kinds, but which denies that kinds have essences or have some reality apart from their instances. I introduce a models-first account of kinds, which suggests that two things are of the same kind to the extent that they can be represented by the same model. Because target entities can be represented by multiple models, they will belong to multiple kinds. I illustrate the approach by showing how the entities and activities that make up mechanisms can be classified into kinds.


1998 ◽  
Vol 12 (5) ◽  
pp. 1054-1065 ◽  
Author(s):  
Elizabeth E. Crone ◽  
Janet L. Gehring

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 665
Author(s):  
Hui Yu ◽  
Yan Guo ◽  
Jingchun Chen ◽  
Xiangning Chen ◽  
Peilin Jia ◽  
...  

Transcriptomic studies of mental disorders using the human brain tissues have been limited, and gene expression signatures in schizophrenia (SCZ) remain elusive. In this study, we applied three differential co-expression methods to analyze five transcriptomic datasets (three RNA-Seq and two microarray datasets) derived from SCZ and matched normal postmortem brain samples. We aimed to uncover biological pathways where internal correlation structure was rewired or inter-coordination was disrupted in SCZ. In total, we identified 60 rewired pathways, many of which were related to neurotransmitter, synapse, immune, and cell adhesion. We found the hub genes, which were on the center of rewired pathways, were highly mutually consistent among the five datasets. The combinatory list of 92 hub genes was generally multi-functional, suggesting their complex and dynamic roles in SCZ pathophysiology. In our constructed pathway crosstalk network, we found “Clostridium neurotoxicity” and “signaling events mediated by focal adhesion kinase” had the highest interactions. We further identified disconnected gene links underlying the disrupted pathway crosstalk. Among them, four gene pairs (PAK1:SYT1, PAK1:RFC5, DCTN1:STX1A, and GRIA1:MAP2K4) were normally correlated in universal contexts. In summary, we systematically identified rewired pathways, disrupted pathway crosstalk circuits, and critical genes and gene links in schizophrenia transcriptomes.


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