Physiology of Bone Formation, Remodeling, and Metabolism

The purpose of this study was to clarify the effects of dietary calcium (Ca) supplementation on bone metabolism of magnesium (Mg)-deficient rats. Male Wistar rats were randomized by weight into three groups, and fed a control diet (control group), a Mg-deficient diet (Mg- group) or a Mg-deficient diet having twice the control Ca concentrations (Mg-2Ca group) for 14 days. Trabecular bone volume was significantly lower in the Mg - and Mg-2Ca groups than in the control group. Trabecular number was also significantly lower in the Mg - and Mg-2Ca groups than in the control group. Mineralizing bone surface, mineral apposition rate (MAR), and surface referent bone formation rate (BFR/BS) were significantly lower in the Mg - and Mg-2Ca groups than in the control group. Furthermore, MAR and BFR/BS were significantly lower in the Mg-2Ca group than in the Mg - group. These results suggest that dietary Ca supplementation suppresses bone formation in Mg-deficient rats.

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Bone Formation and Osteoclast Remodeling in Calcified Cardiac Valves: A Clinical and Pathologic Analysis

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)88192-2 ◽

1998 ◽

Vol 31 (2) ◽

pp. 503A ◽

Cited By ~ 5

Author(s):

E Mohler

Keyword(s):

Bone Formation ◽

Cardiac Valves ◽

Pathologic Analysis

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Bone formation in a carcinoma of the maxillary antrum

Dentomaxillofacial Radiology ◽

10.1038/sj.dmfr.4600474 ◽

1999 ◽

Vol 28 (6) ◽

pp. 375-377 ◽

Cited By ~ 4

Author(s):

K Lee ◽

Y Suei ◽

T Yamada ◽

S Masuda ◽

I Ogawa ◽

...

Keyword(s):

Bone Formation ◽

Maxillary Antrum

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Molecular Mechanisms of Heterotopic Bone Formation

Hormone and Metabolic Research ◽

10.1055/s-0032-1304251 ◽

2012 ◽

Vol 44 (10) ◽

Cited By ~ 4

Author(s):

S Zhang ◽

FS Kaplan ◽

EM Shore

Keyword(s):

Bone Formation ◽

Molecular Mechanisms ◽

Heterotopic Bone ◽

Heterotopic Bone Formation

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[18F]Fluoride PET Indicates Reduced Bone Formation in Severe Glucocorticoid-induced Osteoporosis

Nuklearmedizin ◽

10.1055/s-0038-1629797 ◽

1998 ◽

Vol 37 (02) ◽

pp. 76-79 ◽

Cited By ~ 8

Author(s):

T. D. Kirchhoff ◽

W. Burchert ◽

J. v. d. Hoff ◽

H. Zeidler ◽

H. Hundeshagen ◽

...

Keyword(s):

Bone Formation ◽

Multiple Organ ◽

High Dose ◽

Multiple Fractures ◽

Glucocorticoid Treatment ◽

Organ Manifestations ◽

Diagnostic Benefit ◽

Sharp Syndrome ◽

18F Fluoride

SummaryA 61-year-old female patient presenting with mixed connective tissue disease (Sharp syndrome), underwent a long-term high dose glucocorticoid treatment because of multiple organ manifestations. Under steroid therapy she developed severe osteoporosis resulting in multiple fractures. A dynamic [18F]fluoride PET study in this patient revealed reduced fluoride influx in non-fractured vertebrae. This finding corresponds to pathogenetic concepts which propose an inhibition of bone formation as major cause of glucocorticoid-induced osteoporosis. In the light of the presented case it seems to be promising to evaluate the diagnostic benefit of [18F]fluoride PET in osteoporosis.

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