Correlating Tissue Response with Anatomical Location of mTBI Using a Human Head Finite Element Model under Simulated Blast Conditions

Author(s):  
T. P. Harrigan ◽  
J. C. Roberts ◽  
E. E. Ward ◽  
A. C. Merkle
2020 ◽  
Vol 142 (7) ◽  
Author(s):  
Lauren Dawson ◽  
David Koncan ◽  
Andrew Post ◽  
Roger Zemek ◽  
Michael D. Gilchrist ◽  
...  

Abstract Accidental falls occur to people of all ages, with some resulting in concussive injury. At present, it is unknown whether children and adolescents are at a comparable risk of sustaining a concussion compared to adults. This study reconstructed the impact kinematics of concussive falls for children, adolescents, and adults and simulated the associated brain tissue deformations. Patients included in this study were diagnosed with a concussion as defined by the Zurich Consensus guidelines. Eleven child, 10 adolescent, and 11 adult falls were simulated using mathematical dynamic models(MADYMO), with three ellipsoid pedestrian models sized to each age group. Laboratory impact reconstruction was conducted using Hybrid III head forms, with finite element model simulations of the brain tissue response using recorded impact kinematics from the reconstructions. The results of the child group showed lower responses than the adolescent group for impact variables of impact velocity, peak linear acceleration, and peak rotational acceleration but no statistical differences existed for any other groups. Finite element model simulations showed the child group to have lower strain values than both the adolescent and adult groups. There were no statistical differences between the adolescent and adult groups for any variables examined in this study. With the cases included in this study, young children sustained concussive injuries at lower modeled brain strains than adolescents and adults, supporting the theory that children may be more susceptible to concussive impacts than adolescents or adults.


2015 ◽  
Vol 08 (06) ◽  
pp. 1550074 ◽  
Author(s):  
Akshara Makrariya ◽  
Neeru Adlakha

Temperature as an indicator of tissue response is widely used in clinical applications. In view of above a problem of temperature distribution in peripheral regions of extended spherical organs of a human body like, human breast involving uniformly perfused tumor is investigated in this paper. The human breast is assumed to be spherical in shape with upper hemisphere projecting out from the trunk of the body and lower hemisphere is considered to be a part of the body core. The outer surface of the breast is assumed to be exposed to the environment from where the heat loss takes place by conduction, convection, radiation and evaporation. The heat transfer from core to the surface takes place by thermal conduction and blood perfusion. Also metabolic activity takes place at different rates in different layers of the breast. An elliptical-shaped tumor is assumed to be present in the dermis region of human breast. A finite element model is developed for a two-dimensional steady state case incorporating the important parameters like blood flow, metabolic activity and thermal conductivity. The triangular ring elements are employed to discretize the region. Appropriate boundary conditions are framed using biophysical conditions. The numerical results are used to study the effect of tumor on temperature distribution in the region.


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