Plasma DNA As A Noninvasive Monitoring Tool For Trauma Patients

2004 ◽  
pp. 142-153
Author(s):  
Y. M. D. Lo ◽  
T. H. Rainer
Keyword(s):  
Noninvasive Monitoring ◽  
Trauma Patients ◽  
Plasma Dna ◽  
Monitoring Tool

NONINVASIVE MONITORING IN TRAUMA PATIENTS WITH GUNSHOT WOUNDS

1995 ◽  
Vol 23 (Supplement) ◽  
pp. A232
Author(s):  
Michael H. Bishop ◽  
William Shoemaker ◽  
Julia Shuleshko ◽  
Harini Thadepalli ◽  
Christy Stephen ◽  
...  
Keyword(s):  
Gunshot Wounds ◽  
Noninvasive Monitoring ◽  
Trauma Patients

Abstract 18459: CT-guided Planar Imaging for the Assessment of Right Ventricular Myocardial Perfusion: a Novel, Noninvasive Monitoring Tool for Patients With Pulmonary Hypertension

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ken Kato ◽  
Hideyuki Miyauchi ◽  
Takashi Iimori ◽  
Koichi Sawada ◽  
Yoichi Kuwabara ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Myocardial Perfusion ◽  
Right Ventricular ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Noninvasive Monitoring ◽  
Study Groups ◽  
Planar Imaging ◽  
Monitoring Tool ◽  
Ct Guided ◽  
Optimal Angle

Introduction: In patients with pulmonary hypertension (PH), right ventricular (RV) dysfunction as a consequence of increased RV pressure may result in RV enlargement and hypertrophy, which also increases the RV myocardial perfusion. Hypothesis: We assessed the hypothesis that RV myocardial perfusion detected by planar thallium-201 (201Tl) imaging is useful for quantitative evaluation for RV dysfunction in PH patients. Method: The study groups included 16 PH patients with chronic thromboembolic pulmonary hypertension (CTEPH) and 24 healthy controls. All subjects underwent myocardial perfusion SPECT/CT. Cardiac CT was used to obtain the optimal angle to differentiate the RV from the left ventricle (LV). Forty minutes after intravenously administration of 111 MBq of 201Tl, planar acquisition from the optimal angle was performed. In the planar image, we measured the total counts of 201Tl in the RV and LV. The relative count of the RV to LV (HR/HL) was calculated as RV myocardial perfusion indicator for this study. Mean pulmonary artery pressure (mPAP) by cardiac catheterization was obtained in all PH patients to estimate the severity. Results: HR/HL was significantly elevated in the PH group compared with control (0.57 ± 0.13 vs. 0.36 ± 0.07, p <0.01). In the PH group, average mPAP was 42.2 ± 8.84mmHg, which was significantly correlated with HR/HL (r=0.70, p<0.01). In 7 patients with CTEPH who underwent pulmonary endarterectomy (PEA), HR/HL significantly decreased after PEA (from 0.57±0.16 to 0.42±0.07, p<0.05). The decrease of HR/HL was significantly associated with the decrease of mPAP after PEA (r=0.78, p<0.05). Conclusion: Relative RV accumulation in CT-guided 201Tl planar imaging by SPECT/CT was associated with the severity of PH in CTEPH patients and decreased after surgical treatment of CTEPH in parallel with the reduction of mPAP. This method may represent a novel, noninvasive monitoring tool for PH patients.

Continuous noninvasive monitoring of cardiac performance and tissue perfusion in pediatric trauma patients

2005 ◽  
Vol 40 (12) ◽  
pp. 1957-1963 ◽  
Author(s):  
Matthew Martin ◽  
Carlos Brown ◽  
David Bayard ◽  
Demetrios Demetriades ◽  
Ali Salim ◽  
...  
Keyword(s):  
Pediatric Trauma ◽  
Tissue Perfusion ◽  
Noninvasive Monitoring ◽  
Cardiac Performance ◽  
Trauma Patients

scholarly journals The Revised Digital Transcutaneous PCO2/SpO2 Ear Sensor Is a Reliable Noninvasive Monitoring Tool in Patients After Cardiac Surgery

2011 ◽  
Vol 25 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Regine Roediger ◽  
Beatrice Beck-Schimmer ◽  
Oliver M. Theusinger ◽  
Denise Rusch ◽  
Burkhardt Seifert ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Noninvasive Monitoring ◽  
Monitoring Tool

The Clinical Significance of Plasma DNA Quantification for Quake Trauma Patients

2010 ◽  
pp. 171-182 ◽  
Author(s):  
Dan Chen ◽  
Shiyang Pan ◽  
Shijiang Zhang ◽  
Peijun Huang ◽  
Wenying Xia ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Dna Quantification ◽  
Trauma Patients ◽  
Plasma Dna

scholarly journals Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Radha S. P. Malon ◽  
Sahba Sadir ◽  
Malarvili Balakrishnan ◽  
Emma P. Córcoles
Keyword(s):  
Clinical Diagnosis ◽  
Noninvasive Monitoring ◽  
Research Field ◽  
Clinical Diagnostics ◽  
Blood Sampling ◽  
Monitoring Tool ◽  
Therapeutic Applications ◽  
Salivary Biomarkers ◽  
Disease States

Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.

scholarly journals Time Course of Early and Late Changes in Plasma DNA in Trauma Patients

2003 ◽  
Vol 49 (8) ◽  
pp. 1286-1291 ◽  
Author(s):  
Nicole Y L Lam ◽  
Timothy H Rainer ◽  
Lisa Y S Chan ◽  
Gavin M Joynt ◽  
Y M Dennis Lo
Keyword(s):  
Organ Failure ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Time Course ◽  
Temporal Changes ◽  
Multiple Organ ◽  
Trauma Patients ◽  
Multiple Organ Dysfunction ◽  
Plasma Dna ◽  
Severe Injuries

Abstract Background: Cell-free DNA concentrations increase in the circulation of patients after trauma and may have prognostic potential, but little is know concerning the temporal changes or clearance of the DNA or its relationships with posttraumatic complications. We investigated temporal changes in plasma DNA concentrations in patients after trauma with use of real-time quantitative PCR. Methods: Serial plasma samples were taken from two trauma populations. In the first study, samples were collected every 20 min from 25 patients within the first 3 h of trauma. In the second study, samples were collected every day from 36 other trauma patients admitted to the intensive care unit (ICU). Results: In the first study, plasma DNA was increased within 20 min of injury and was significantly higher in patients with severe injury and in patients who went on to develop organ failure. In patients with less severe injuries, plasma DNA concentrations decreased toward reference values within 3 h. In the second study, plasma DNA concentrations were higher in patients who developed multiple organ dysfunction syndrome between the second and fourth days of admission than in patients who did not develop the syndrome. In patients who remained in the ICU with continuing organ dysfunction, plasma DNA remained higher than in healthy controls even at 28 days after injury. Most survivors with multiple organ dysfunction syndrome showed an initial very high peak followed by a prolonged smaller increase. Conclusions: Plasma DNA concentrations increase early after injury and are higher in patients with severe injuries and in those who develop organ failure. Increased plasma DNA persists for days after injuries, especially in patients with multiple organ dysfunction syndrome.

212: Plasma DNA Based Detection of Renal Cell Carcinoma by using New Multiplex Molecular Assay

2007 ◽  
Vol 177 (4S) ◽  
pp. 71-71
Author(s):  
Woo Chul Moon ◽  
C. Noh ◽  
T. Kim ◽  
Sy Oh ◽  
J. Shin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Molecular Assay ◽  
Plasma Dna

Nutritional Needs of Trauma Patients: Challenges, Barriers, and Solutions

1994 ◽  
Vol 6 (3) ◽  
pp. 501-514 ◽  
Author(s):  
Christine A. Stamatos ◽  
Elizabeth Reed
Keyword(s):  
Trauma Patients ◽  
Nutritional Needs
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