Estrogen Protects Against Global Ischemia-Induced Neuronal Death and Prevents Activation of Apoptotic Signaling Cascades in the Hippocampal CA1

2004 ◽  
pp. 311-311 ◽  
Author(s):  
T. Jover ◽  
H. Tanaka ◽  
A. Calderone ◽  
K. Oguro ◽  
M. V. L. Bennett ◽  
...  
Keyword(s):  
Neuronal Death ◽  
Global Ischemia ◽  
Signaling Cascades ◽  
Apoptotic Signaling ◽  
Hippocampal Ca1

scholarly journals Estrogen Protects against Global Ischemia-Induced Neuronal Death and Prevents Activation of Apoptotic Signaling Cascades in the Hippocampal CA1

2002 ◽  
Vol 22 (6) ◽  
pp. 2115-2124 ◽  
Author(s):  
Teresa Jover ◽  
Hidenobu Tanaka ◽  
Agata Calderone ◽  
Keiji Oguro ◽  
Michael V. L. Bennett ◽  
...  
Keyword(s):  
Neuronal Death ◽  
Global Ischemia ◽  
Signaling Cascades ◽  
Apoptotic Signaling ◽  
Hippocampal Ca1

Abstract WP329: The Role of miR-34b/c in Global Ischemic Stroke

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Hyae-Ran Byun ◽  
Morgan Porch ◽  
Fabrizio Pontarelli ◽  
Brenda L Court Vazquez ◽  
R.Suzanne Zukin ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Deficits ◽  
Neuronal Death ◽  
Target Genes ◽  
Pyramidal Neurons ◽  
Unmet Need ◽  
Global Ischemia ◽  
Hippocampal Ca1

Transient global ischemia arising as a consequence of cardiac arrest in humans causes selective, delayed death of hippocampal CA1 pyramidal neurons and cognitive impairment. Effective treatments to ameliorate the neurodegeneration and cognitive dysfunction associated with global ischemia are an unmet need. Emerging evidence points to a widespread role for microRNAs (miRNAs) as key modulators of target gene expression in neurons. Accordingly, dysregulation of miRNAs are implicated in the pathophysiology of neurodegenerative disease and neurological disorders. Our findings, derived via miRNA-seq, indicate that expression of a subset of microRNAs are altered in postischemic CA1 including miR-34b/c, miR-21, miR-331, miR-181 and miR-29. Ingenuity pathway analysis reveals that miR-34b/c is the leading miR candidate implicated in cell death and survival. A role for miR-34 in the pathogenesis of global ischemia is, as yet, unclear. Here we show ischemia induces p53-dependent activation of miR-34b/c and downregulation of its target genes Bcl-2 and Sirt1, which together promote neuronal death in selectively vulnerable hippocampal CA1 in vivo . Consistent with this, inhibition of miR-34b/c affords neuroprotection, rescues impaired synaptic plasticity and reduces memory deficits in global ischemia. These findings document a causal role for p53-dependent activation of miR-34b/c in neuronal death and identify a novel therapeutic target for amelioration of the neurodegeneration and cognitive deficits associated with ischemic stroke.

Diazepam delays the death of hippocampal CA1 neurons following global ischemia

2008 ◽  
Vol 214 (2) ◽  
pp. 309-314 ◽  
Author(s):  
Dale Corbett ◽  
Jennifer Larsen ◽  
Kristopher D. Langdon
Keyword(s):  
Global Ischemia ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1

Accumulation of apolipoprotein E and β-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death

Neuroreport ◽  
1996 ◽  
Vol 7 (18) ◽  
pp. 3063-3068 ◽  
Author(s):  
Hirohisa Ishimaru ◽  
Koichi Ishikawa ◽  
Seiichi Haga ◽  
Mikio Shoji ◽  
Yoshihide One ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Pyramidal Cell ◽  
Neuronal Death ◽  
Cell Layer ◽  
Delayed Neuronal Death ◽  
Pyramidal Cell Layer ◽  
Hippocampal Ca1 ◽  
Β Amyloid

Visfatin reduces hippocampal CA1 cells death and improves learning and memory deficits after transient global ischemia/reperfusion

Neuropeptides ◽  
2015 ◽  
Vol 49 ◽  
pp. 63-68 ◽  
Author(s):  
Sohaila Erfani ◽  
Mehdi Khaksari ◽  
Shahrbanoo Oryan ◽  
Nabi Shamsaei ◽  
Nahid Aboutaleb ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Ischemia Reperfusion ◽  
Memory Deficits ◽  
Global Ischemia ◽  
Hippocampal Ca1 ◽  
Transient Global Ischemia ◽  
Learning And Memory Deficits ◽  
Cells Death ◽  
Ca1 Cells

Effect of hypotension severity on hippocampal CA1 neurons in a rat global ischemia model

2000 ◽  
Vol 877 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Taku Sugawara ◽  
Makoto Kawase ◽  
Anders Lewén ◽  
Nobuo Noshita ◽  
Yvan Gasche ◽  
...  
Keyword(s):  
Global Ischemia ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1
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