Improving Parallel I/O Performance Using Multithreaded Two-Phase I/O with Processor Affinity Management

ObjectivesTo explore the type of education needed for nurses when dealing with aggression from patients and their families.DesignA two-phase sequential mixed-methods study.SettingThis study was conducted in Japan, with phase I from March to November 2016 and phase II in November 2018.Main outcome measuresThe challenges faced by nurses when dealing with incidents of aggression from the neutral perspective of neither nurse nor patient/family and perceptions of the educational contents developed in this study. Descriptive analyses were used to examine the data retrieved from both phases.ParticipantsPhase I entailed semistructured interviews among 11 neutral-party participants who observed aggressive incidents between nurses and patients/families. Phase II consisted of a web survey conducted among 102 nursing students and 308 nursing professionals.ResultsPhase I resulted in the identification of the following five main educational components: understanding the mechanisms of anger and aggression, maintaining self-awareness, observant listening, managing the self-impression, and communicating based on specific disease characteristics. Each component was related to improved communication through self-awareness. The results of phase II indicated that participants positively perceived these educational contents as likely to be effective for dealing with aggression from patients/families.ConclusionsThis study clarified the type of education needed for nurses when dealing with aggression based on multiple viewpoints. Specifically, neutral-party interviews revealed that communication should be improved through self-awareness. A subsequent survey among nurses and nursing students showed that the identified educational contents were positively received.

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A new fully human recombinant FSH (follitropin epsilon): two phase I randomized placebo and comparator-controlled pharmacokinetic and pharmacodynamic trials

Human Reproduction ◽

10.1093/humrep/dex220 ◽

2017 ◽

Vol 32 (8) ◽

pp. 1639-1647 ◽

Cited By ~ 6

Author(s):

Khalid Abd-Elaziz ◽

Ingrid Duijkers ◽

Lars Stöckl ◽

Bruno Dietrich ◽

Christine Klipping ◽

...

Keyword(s):

Phase I ◽

Recombinant Fsh ◽

Two Phase

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Relative Bioavailability of Orally Dispersible Tablet Formulations of Levo‐ and Racemic Praziquantel: Two Phase I Studies

Clinical and Translational Science ◽

10.1111/cts.12601 ◽

2018 ◽

Vol 12 (1) ◽

pp. 66-76 ◽

Cited By ~ 2

Author(s):

Wilhelmina Maria Bagchus ◽

Deon Bezuidenhout ◽

Eleanor Harrison‐Moench ◽

Elly Kourany‐Lefoll ◽

Peter Wolna ◽

...

Keyword(s):

Phase I ◽

Relative Bioavailability ◽

Two Phase ◽

Phase I Studies ◽

Dispersible Tablet ◽

Tablet Formulations

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Mixed methods study protocol to examine perceptions of family medicine among long-term patients of a family medicine clinic in Japan

BMJ Open ◽

10.1136/bmjopen-2020-037113 ◽

2020 ◽

Vol 10 (9) ◽

pp. e037113

Author(s):

Kotaro Sato ◽

Ryoko Michinobu ◽

Tesshu Kusaba

Keyword(s):

Primary Care ◽

Mixed Methods ◽

Family Medicine ◽

Phase I ◽

Phase Ii ◽

Medical Specialty ◽

Structured Interviews ◽

Two Phase ◽

Care Systems

IntroductionFamily physicians or general practitioners play central roles in many countries’ primary care systems, but family medicine (FM) remains relatively unestablished in Japan. Previous studies in Japan have examined the general population’s understanding of FM as a medical specialty, but none have explored this topic using actual FM clinic patients. Here, we describe a protocol to explore the perceptions of FM among long-term patients of one of Japan’s oldest FM clinics.Methods and analysisThe study will be conducted at the Motowanishi Family Clinic in Hokkaido, Japan, using patients who have attended the clinic for over 10 years. The analysis will adopt a two-phase explanatory sequential mixed methods design. During phase I, quantitative data from participants’ medical records will be collected and reviewed, and patients’ perceptions of FM will be assessed through a questionnaire. The correlations between participants’ knowledge that the clinic specialises in FM and various characteristics will be examined. In phase II, qualitative data will be collected through semi-structured interviews of approximately 10 participants selected using maximum variation sampling based on phase I results. A thematic analysis will be conducted in phase II to identify patients’ perceptions and changes in perceptions. Finally, each theme identified in phase II will be transformed into a quantitative variable to analyse the relationships between the phases. A joint display will be used to integrate the phases’ findings and examine how phase II results explain phase I results.Ethics and disseminationThe institutional review board of the Japan Primary Care Association has approved this research (2019-003). The results will be presented at the association’s annual academic meeting and submitted for publication in relevant journals. The findings will also be provided to the patients via the clinic’s internal newsletter.

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Stereobody radiotherapy for nodal recurrences in oligometastatic patients: a pooled analysis from two phase I clinical trials

Clinical & Experimental Metastasis ◽

10.1007/s10585-020-10039-x ◽

2020 ◽

Vol 37 (4) ◽

pp. 519-529

Author(s):

Francesco Deodato ◽

Milena Ferro ◽

Savino Cilla ◽

Anna Ianiro ◽

Milly Buwenge ◽

...

Keyword(s):

Clinical Trials ◽

Phase I ◽

Pooled Analysis ◽

Phase I Clinical Trials ◽

Two Phase

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COVID-19 and radiation oncology: the experience of a two-phase plan within a single institution in central Italy

Radiation Oncology ◽

10.1186/s13014-020-01670-9 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Luciana Caravatta ◽

Consuelo Rosa ◽

Maria Bernadette Di Sciascio ◽

Andrea Tavella Scaringi ◽

Angelo Di Pilla ◽

...

Keyword(s):

Phase I ◽

Phase Ii ◽

Central Italy ◽

Significant Risk ◽

Tumor Board ◽

Radiotherapy Planning ◽

Two Phase ◽

Hospital Environments ◽

Two Phases

Abstract Background COVID-19 in Italy has led to the need to reorganize hospital protocols with a significant risk of interruption to cancer treatment programs. In this report, we will focus on a management model covering the two phases of the COVID-19 emergency, namely lockdown-phase I and post-lockdown-phase II. Methods The following steps were taken in the two phases: workload during visits and radiotherapy planning, use of dedicated routes, measures for triage areas, management of suspected and positive COVID-19 cases, personal protective equipment, hospital environments and intra-institutional meetings and tumor board management. Due to the guidelines set out by the Ministry of Health, oncological follow-up visits were interrupted during the lockdown-phase I; consequently, we set about contacting patients by telephone, with laboratory and instrumental exams being viewed via telematics. During the post-lockdown-phase II, the oncological follow-up clinic reopened, with two shifts operating daily. Results By comparing our radiotherapy activity from March 9 to May 4 2019 with the same period in 2020 during full phase I of the COVID-19 emergency, similar results were achieved. First radiotherapy visits, Simulation Computed Tomography and Linear Accelerator treatments amounted to 123, 137 and 151 in 2019 compared with 121, 135 and 170 in 2020 respectively. There were no cases of COVID-19 positivity recorded either in patients or in healthcare professionals, who were all negative to the swab tests performed. Conclusion During both phases of the COVID-19 emergency, the planned model used in our own experience guaranteed both continuity in radiotherapy treatments whilst neither reducing workload nor interrupting treatment and, as such, it ensured the safety of cancer patients, hospital environments and staff.

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Outliers in L2 Research in Applied Linguistics: A Synthesis and Data Re-Analysis

Annual Review of Applied Linguistics ◽

10.1017/s0267190520000057 ◽

2020 ◽

Vol 40 ◽

pp. 26-55 ◽

Cited By ~ 1

Author(s):

Christopher Nicklin ◽

Luke Plonsky

Keyword(s):

Phase I ◽

Relative Effectiveness ◽

Reaction Time Data ◽

Future Research ◽

Time Data ◽

Two Phase ◽

Raw Data ◽

Study Results ◽

Using Data ◽

The Impact

AbstractData from self-paced reading (SPR) tasks are routinely checked for statistical outliers (Marsden, Thompson, & Plonsky, 2018). Such data points can be handled in a variety of ways (e.g., trimming, data transformation), each of which may influence study results in a different manner. This two-phase study sought, first, to systematically review outlier handling techniques found in studies that involve SPR and, second, to re-analyze raw data from SPR tasks to understand the impact of those techniques. Toward these ends, in Phase I, a sample of 104 studies that employed SPR tasks was collected and coded for different outlier treatments. As found in Marsden et al. (2018), wide variability was observed across the sample in terms of selection of time and standard deviation (SD)-based boundaries for determining what constitutes a legitimate reading time (RT). In Phase II, the raw data from the SPR studies in Phase I were requested from the authors. Nineteen usable datasets were obtained and re-analyzed using data transformations, SD boundaries, trimming, and winsorizing, in order to test their relative effectiveness for normalizing SPR reaction time data. The results suggested that, in the vast majority of cases, logarithmic transformation circumvented the need for SD boundaries, which blindly eliminate or alter potentially legitimate data. The results also indicated that choice of SD boundary had little influence on the data and revealed no meaningful difference between trimming and winsorizing, implying that blindly removing data from SPR analyses might be unnecessary. Suggestions are provided for future research involving SPR data and the handling of outliers in second language (L2) research more generally.

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