Lymphoid Hyperplasia - Pseudotumor of the Orbit, Castleman’s Disease

2003 ◽  
pp. 193-194
Author(s):  
Stanley E. Order ◽  
Sarah S. Donaldson
Keyword(s):  
Castleman’S Disease ◽  
Lymphoid Hyperplasia ◽  
Castleman's Disease

Reactive lymphoid hyperplasia of the liver characterized by an angiofollicular pattern mimicking Castleman's disease

1996 ◽  
Vol 46 (10) ◽  
pp. 782-786 ◽  
Author(s):  
Tohru Tanizawa ◽  
Yoshinobu Eishi ◽  
Ryuichi Kamiyama ◽  
Madoka Nakahara ◽  
Yoshihisa Abo ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Lymphoid Hyperplasia ◽  
Reactive Lymphoid Hyperplasia ◽  
Castleman's Disease

scholarly journals Role of Fine needle aspiration cytology in the diagnosis of Cervical lymphadenopathy

1970 ◽  
Vol 14 (2) ◽  
pp. 63-65 ◽  
Author(s):  
Md Arif Hossain Bhuiyan ◽  
Md Abu Yusuf Fakir ◽  
ABM Tofazzal Hossain ◽  
AHM Zahurul Huq ◽  
Sanjeev Gupta
Keyword(s):  
Frozen Section ◽  
Castleman’S Disease ◽  
Cervical Lymphadenopathy ◽  
Neck Surgery ◽  
Needle Aspiration ◽  
Lymphoid Hyperplasia ◽  
Lymph Node Biopsy ◽  
Castleman's Disease ◽  
Needle Aspiration Cytology ◽  
Set Up

Objective: A study was carried out to know the overall prevalence of various causes responsible for cervical lymphadenopathy of more than 3 weeks duration. FNAC has been evaluated as a diagnostic tool in our clinical set up. We aimed to present 110 cases which we treated in our center within last 3½ years. Methods: A retrospective study has been carried out from June 2005 to December 2008 in the department of Otolaryngology and Head-Neck Surgery at Apollo Hospitals Dhaka. All patients presented with cervical lymphadenopathy of more than 3 weeks duration. FNAC has been done for all suspected cases. CT neck has been done in 4 cases for deep jugular nodes. 55 patients underwent biopsy as FNAC report was non-specific lymphadenitis. For three cases we have done frozen section biopsy. Preoperative workup with routine blood tests, Xray chest and tuberculin tests have been carried out for all cases. Results: Out of 110 FNAC of cervical lymphadenopathy - 55 were non-specific lymphadenitis, 32 were tuberculosis, 12 were metastatic (with 2 occult primary), 6 were lymphomas(Immunocytochemistry proved ) and 5 were abscess. All 55 non-specific lymphadenopathy cases (FNAC report) underwent lymph node biopsy.5 cases were consistent with tuberculosis , 1 was lymphoma and rest were reactive . For 3 cases frozen section biopsy have been done. One was consistent with granulomatous disease and two cases were diagnosed as lymphoid hyperplasia. Both the lymphoid hyperplasia cases have been diagnosed as Castleman's disease after histopathology report. Conclusion: The study concluded the fact that the non-specific infection is the most common cause of cervical lymphadenopathy followed by tuberculosis .Supplemented with routine laboratory investigations, FNAC give very important clue to the physicians among patients presented with cervical lymphadenopathy. Key Words: Lymphadenopathy, lymphoid hyperplasia, tuberculosis, lymphoma, castleman's disease.  DOI: 10.3329/bjo.v14i2.3283 Bangladesh J of Otorhinolaryngology 2008; 14(2) : 63-65

A Long-Term (5-Year) Sustained Efficacy of Tocilizumab for Multicentric Castleman’s Disease and the Effect on Pulmonary Complications.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 646-646 ◽  
Author(s):  
Norihiro Nishimoto ◽  
Osamu Honda ◽  
Hiromitsu Sumikawa ◽  
Takeshi Johkoh ◽  
Katsuyuki Aozasa ◽  
...  
Keyword(s):  
Clinical Improvement ◽  
Castleman’S Disease ◽  
Lymphoid Hyperplasia ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Amyloid A ◽  
Pulmonary Manifestations ◽  
Tract Infections ◽  
Multicentric Castleman's Disease

Abstract Multicentric Castleman’s disease (MCD) is an atypical lymphoproliferative disease, which is closely associated with dysregulated overproduction of interleukin-6 (IL-6). These patients have numerous complications including secondary amyloidosis, paraneoplastic mucocutaneous disease, renal failure, and pulmonary manifestations such as diffuse lymphoid hyperplasia. We previously reported on a 60 weeks study of the humanized anti-human IL-6 receptor monoclonal antibody tocilizumab (TCZ) in patients with MCD and showed that TCZ provides rapid clinical improvement in constitutional symptoms as well as biochemical markers such as c-reactive protein, erythrocyte sedimentation rate, serum amyloid A, hemoglobin, and albumin levels. In this long-term follow-up over 5 years, we investigated the efficacy and safety of TCZ. Patients received TCZ monotherapy at 8 mg/kg intravenously every 2 weeks for 5 years. The dose and dosing interval were allowed to be adjusted according to disease activity. Pulmonary diffuse lymphoid hyperplasia was examined by high resolution computed tomography (HRCT) and evaluated and scored by 2 independent radiologists who were blinded to the time sequence of the images and clinical response of each patient. This study complied with all provisions of the Declaration of Helsinki and was conducted in accordance with Good Clinical Practice guidelines. Thirty-five patients were enrolled in this clinical trial and 30 patients (86%) continued TCZ treatment over the period of 5 years. The reduction in size of enlarged lymph nodes as reported previously was sustained. Clinical improvement in constitutional symptoms as well as the improvement of laboratory markers was maintained. Twenty-two patients had received corticosteroids at baseline (mean corticosteroid dose was 16.5 mg/day prednisolone equivalent), and 11 patients (50%) were able to discontinue corticosteroid therapy without flare. Pulmonary diffuse lymphoid hyperplasia was identified in 31 patients at baseline. Significant improvement was observed in the scores of centrilobular nodules, interlobular septal thickening, bronchovascular bundle thickening and ground glass attenuation with 50 to 60% reductions evaluated by HRCT over the 5 year period. No statistically significant change was observed in scores of cyst and airspace consolidation. TCZ was generally well tolerated during this 5 years treatment. The majority of adverse events (AEs) were mild to moderate in severity. Most frequently reported AEs were mild to moderate infections such as common cold and urinary tract infections (2.3 AEs / patient year). In conclusion, in this 5 years extension study tocilizumab demonstrated an excellent long term efficacy on inflammatory manifestations and pulmonary diffuse lymphoid hyperplasia. Tocilizumab treatment also showed a very good safety profile.

scholarly journals Angiofollicular Lymphoid Hyperplasia (Castleman's Disease) in Two Mice Treated with Polyoma Virus or Urethane

1993 ◽  
Vol 21 (1) ◽  
pp. 26-34 ◽  
Author(s):  
A. Olufemi Williams ◽  
Peter M. Banks ◽  
Annabel G. Liebelt ◽  
Harold L. Stewart ◽  
Umberto Saffiotti
Keyword(s):  
Castleman’S Disease ◽  
Lymphoid Hyperplasia ◽  
Polyoma Virus ◽  
Castleman's Disease

scholarly journals A rare disease with pregnancy: Castleman case report

2021 ◽  
Vol 33 (4) ◽  
pp. 300-302
Author(s):  
Özen Esra Karaman ◽  
Çetin Kılıççı ◽  
Pelin Özdemir Önder
Keyword(s):  
Rare Disease ◽  
Preoperative Diagnosis ◽  
Perioperative Management ◽  
Castleman’S Disease ◽  
Lymphoid Hyperplasia ◽  
Lymphoproliferative Disease ◽  
Pathological Examination ◽  
Diagnostic Tools ◽  
Unknown Etiology ◽  
Castleman's Disease

Castleman’s disease was first described by Castleman et al. in 1956 as a non-lymphoproliferative disease. Castleman’s disease (CD), or angiofollicular lymphoid hyperplasia, is a rare disease with unknown etiology that can be easily misdiagnosed as lymphoma, neoplasm, or infection. Very few cases of pelvic origin and observed in pregnancy have been reported in the literature and are usually asymptomatic. Preoperative diagnosis is very difficult due to nonspecific imaging findings and rarity; most cases are diagnosed based on postoperative pathological examination. In this paper, a case of a 36-year-old pregnant woman suspected of adnexal origin in the uterine posterolateral, which was detected incidentally by ultrasound, was presented. The patient underwent a successful mass excision. Pathology of mass observed to be in the pelvic retroperitoneum was detected as localized unicentric and hyaline vascular CD. The study was conducted to discuss the diagnostic tools and perioperative management needed to identify the retroperitoneal unicentric Castleman case

Lymphoid hyperplasia of the thymus showing Castleman’s disease in a patient with myasthenia gravis

2011 ◽  
Vol 32 (11) ◽  
pp. 3695-3697 ◽  
Author(s):  
Masaru Kojima ◽  
Kazuhiko Shimizu ◽  
Yuko Kaneko ◽  
Nobuhide Masawa ◽  
Naoya Nakamura
Keyword(s):  
Myasthenia Gravis ◽  
Castleman’S Disease ◽  
Lymphoid Hyperplasia ◽  
Castleman's Disease

scholarly journals Idiopathic multicentric Castleman’s disease, infrequent cause of Lupus-like. Case Report.

2019 ◽  
Vol 6 (1) ◽  
pp. 14-17
Author(s):  
Juan Manuel Zapata ◽  
Fernando Andrés Lillo ◽  
Antonio Fabian Cabezas ◽  
Santiago Felipe Andrés Riquelme
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lymph Node ◽  
Lupus Erythematosus ◽  
Castleman’S Disease ◽  
Human Herpesvirus ◽  
Lymphoid Hyperplasia ◽  
Castleman's Disease ◽  
Systemic Lupus ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Systemic Inflammatory Disease

Castleman’s disease (CD) or angiofollicular lymph node hyperplasia includes a heterogeneous mix of reactive lymphoproliferative processes with well-defined histological features. However, they differ in their localization patterns, clinical expression and etiopathogenesis. There are 4 types, one of them is the multicentric CD that is not associated with any viruses and has recently been called idiopathic MCD (iMCD). iMCD is a lymphoproliferative disorder with specific histopathological characteristics, more than one region of affected lymph nodes and absence of infection associated to human herpesvirus 8 and human immunodeficiency virus (HIV). iMCD covers multiple differential diagnoses and might simulate autoimmune diseases such as systemic lupus erythematosus. The aim of this article is to report the case of a patient with Castleman’s disease and lupus-like presentation. We present the case of a 38-year-old man without morbid history, who presented lumbago, fever, diaphoresis and asthenia with two months of evolution, associated to bilateral cervical adenopathies. General examinations result negative, antinuclear antibodies at a dilution of 1/640 were positive, and extractable nuclear antigens were positive suggesting moderate Systemic Lupus Erythematosus (SLE) plus secondary Sjögren’s. Methylprednisolone and Hydroxycloroquine boli were thus initiated. The patient evolved with anasarca, severe anemia, acidosis, polyserositis and multiple mediastinal adenopathies. Immunoglobulin and cyclophosphamide were thus initiated. He later presented fever, thrombocytopenia and nephrotic syndrome. Biopsy of cervical lymph node reported lymphadenitis with polyclonal plasmacytosis and concentric lymphoid hyperplasia, in agreement with iMCD. Treatment with Rituximab was initiated, which led to the favorable evolution of the patient. iMCD is a systemic inflammatory disease, its presentation corresponds to a constitutional syndrome resulting in a wide differential diagnosis. Every time suspicious adenopathies appear, they must be biopsied since this might lead to a definitive diagnosis.

Castleman's Disease Masquerading as Sigmoid Colon Tumor and Hodgkin Lymphoma

Swiss Surgery ◽  
2002 ◽  
Vol 8 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Altinli ◽  
Pekmezci ◽  
Balkan ◽  
Somay ◽  
M. Akif Buyukbese ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Sigmoid Colon ◽  
Castleman’S Disease ◽  
Malignant Potential ◽  
Colon Tumor ◽  
Rare Entity ◽  
Castleman's Disease ◽  
Mediastinal Lymph Nodes ◽  
Histologic Types

Castleman's disease is a benign lymphoid neoplasm first reported as hyperplasia of mediastinal lymph nodes. Some authors referred to the lesions as isolated tumors, described as a variant of Hodgkin's disease with a possibility of a malignant potential and others proposed that the lymphoid masses were of a hamartomatous nature. Three histologic variants and two clinical types of the disease have been described. The disease may occur in almost any area in which lymph nodes are normally found. The most common locations are thorax (63%), abdomen (11%) and axilla (4%). We report two separate histologic types of Castleman's disease which were rare in the literature, mimicking sigmoid colon tumor and Hodgkin lymphoma. The diagnostic and therapeutic aspects of this rare entity is discussed.

A Case of Spontaneous Resolution of Castleman's Disease in the Neck

2012 ◽  
Vol 55 (11) ◽  
pp. 736
Author(s):  
Seong-Hyun Yun ◽  
Soo-Ryang Chae ◽  
Dong-Joon Yoo ◽  
Young-Hoon Joo
Keyword(s):  
Castleman’S Disease ◽  
Spontaneous Resolution ◽  
Castleman's Disease
Sign in / Sign up

Export Citation Format

Share Document