Possible Role of the Friend Virus Life Cycle in Differentiating Friend Leukemia Cells Treated with Interferon

1979 ◽  
pp. 307-311
Author(s):  
A. Dolei ◽  
M. R. Capobianchi ◽  
L. Cioé ◽  
G. Colletta ◽  
G. Vecchio ◽  
...  
Keyword(s):  
Life Cycle ◽  
Leukemia Cells ◽  
Friend Virus ◽  
Virus Life Cycle ◽  
Friend Leukemia

scholarly journals Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle

2021 ◽  
Vol 22 (9) ◽  
pp. 4438
Author(s):  
Jessica Proulx ◽  
Kathleen Borgmann ◽  
In-Woo Park
Keyword(s):  
Immune Response ◽  
Life Cycle ◽  
Deubiquitinating Enzyme ◽  
Deubiquitinating Enzymes ◽  
Antiviral Immune Response ◽  
Cellular Processes ◽  
Virus Life Cycle ◽  
Infected Cells ◽  
Dependent Processes

The ubiquitin (Ub) proteasome system (UPS) plays a pivotal role in regulation of numerous cellular processes, including innate and adaptive immune responses that are essential for restriction of the virus life cycle in the infected cells. Deubiquitination by the deubiquitinating enzyme, deubiquitinase (DUB), is a reversible molecular process to remove Ub or Ub chains from the target proteins. Deubiquitination is an integral strategy within the UPS in regulating survival and proliferation of the infecting virus and the virus-invaded cells. Many viruses in the infected cells are reported to encode viral DUB, and these vial DUBs actively disrupt cellular Ub-dependent processes to suppress host antiviral immune response, enhancing virus replication and thus proliferation. This review surveys the types of DUBs encoded by different viruses and their molecular processes for how the infecting viruses take advantage of the DUB system to evade the host immune response and expedite their replication.

Interferon-induced antiviral actions in Friend leukemia cells: Role of membrane gangliosides

Virology ◽  
1982 ◽  
Vol 117 (2) ◽  
pp. 391-400 ◽  
Author(s):  
F. Belardelli ◽  
A. Aliberti ◽  
B. Santurbano ◽  
G. Antonelli ◽  
G. D'Agnolo ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Friend Leukemia

Reduced maturation of friend virus in adhesive mutants of friend leukemia cells

1987 ◽  
Vol 92 (1-2) ◽  
pp. 151-164
Author(s):  
C. Amici ◽  
C. Oppi ◽  
G. Fiorucci ◽  
A. Battistini ◽  
W. Djaczenko ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Friend Virus ◽  
Friend Leukemia

scholarly journals The role of Ran-binding protein 3 during influenza A virus replication

2013 ◽  
Vol 94 (5) ◽  
pp. 977-984 ◽  
Author(s):  
Rey Predicala ◽  
Yan Zhou
Keyword(s):  
Life Cycle ◽  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
Binding Protein ◽  
Late Phase ◽  
Nuclear Retention ◽  
Interacting Protein ◽  
Virus Life Cycle

Influenza A virus vRNP nuclear export is CRM1-dependent. Ran-binding protein 3 (RanBP3) is a Ran-interacting protein that is best known for its role as a cofactor of CRM1-mediated cargo nuclear export. In this study, we investigated the role of RanBP3 during the influenza A virus life cycle. We found that RanBP3 was phosphorylated at Ser58 in the early and late phases of infection. Knockdown of RanBP3 expression led to vRNP nuclear retention, suggesting that RanBP3 is involved in vRNP nuclear export. Moreover, we demonstrated that the function of RanBP3 during vRNP nuclear export is regulated by phosphorylation at Ser58, and that RanBP3 phosphorylation is modulated by both PI3K/Akt and Ras/ERK/RSK pathways in the late phase of viral infection.

scholarly journals The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1161
Author(s):  
Nawal Al Burtamani ◽  
Alwin Paul ◽  
Ariberto Fassati
Keyword(s):  
Life Cycle ◽  
Small Molecules ◽  
Reverse Transcription ◽  
Nuclear Import ◽  
Protein A ◽  
Host Factors ◽  
Virus Life Cycle ◽  
Experimental Approaches ◽  
Hiv 1

In recent years, major advances in research and experimental approaches have significantly increased our knowledge on the role of the HIV-1 capsid in the virus life cycle, from reverse transcription to integration and gene expression. This makes the capsid protein a good pharmacological target to inhibit HIV-1 replication. This review covers our current understanding of the role of the viral capsid in the HIV-1 life cycle and its interaction with different host factors that enable reverse transcription, trafficking towards the nucleus, nuclear import and integration into host chromosomes. It also describes different promising small molecules, some of them in clinical trials, as potential targets for HIV-1 therapy.

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