Functional Relations Between Dorsal Medullary Inspiratory Neurons and Phrenic Motoneurons

1983 ◽  
pp. 175-184
Author(s):  
M. I. Cohen ◽  
J. L. Feldman ◽  
D. F. Donnelly
Keyword(s):  
Functional Relations ◽  
Phrenic Motoneurons ◽  
Inspiratory Neurons

Excitatory connections between upper cervical inspiratory neurons and phrenic motoneurons in cats

1994 ◽  
Vol 77 (2) ◽  
pp. 679-683 ◽  
Author(s):  
Y. Nakazono ◽  
M. Aoki
Keyword(s):  
Phrenic Nerve ◽  
Respiratory Neurons ◽  
Transmission Delays ◽  
Phrenic Motoneurons ◽  
Inspiratory Neurons ◽  
Upper Cervical ◽  
Cervical Segment ◽  
Focal Cooling ◽  
Descending Influences ◽  
Phrenic Motoneuron

This study aimed to determine whether upper cervical inspiratory neurons (UCINs), which are localized in the intermediolateral part of the gray matter of the upper cervical segments, have propriospinal connections to phrenic motoneurons of the ipsilateral lower cervical segment in anesthetized cats. Unit action potentials of UCINs were extracellularly recorded simultaneously with ipsilateral phrenic nerve activity. To eliminate the descending influences from medullary respiratory neurons to phrenic motoneurons, bulbospinal conduction paths were temporarily blocked by focal cooling applied to the ventral caudal medulla at the pyramidal decussation level by means of a cooling thermode (1 mm tip diam). By using a spike-triggered method, during cooling phrenic nerve activities were evoked by UCIN spikes that were elicited by microinjection of L-glutamate for 20 of the 55 (36%) UCIN units examined. The onset latencies of these phrenic motoneuron responses ranged from 1.5 to 7.1 ms (mean 3.6 ms), depending on synaptic transmission delays. These results clearly demonstrate that UCINs have, at least in part, excitatory mono- and paucisynaptic connections with ipsilateral phrenic motoneurons.

Synaptic connections between medullary inspiratory neurons and phrenic motoneurons as revealed by cross-correlation

1974 ◽  
Vol 81 (2) ◽  
pp. 319-324 ◽  
Author(s):  
Morton I. Cohen ◽  
Montford F. Piercey ◽  
Phyllis M. Gootman ◽  
Paul Wolotsky
Keyword(s):  
Cross Correlation ◽  
Synaptic Connections ◽  
Phrenic Motoneurons ◽  
Inspiratory Neurons

Bo¨tzinger expiratory neurons may inhibit phrenic motoneurons and medullary inspiratory neurons during vomiting

1990 ◽  
Vol 521 (1-2) ◽  
pp. 352-354 ◽  
Author(s):  
Alan D. Miller ◽  
Satoshi Nonaka
Keyword(s):  
Phrenic Motoneurons ◽  
Inspiratory Neurons ◽  
Expiratory Neurons

Bilateral connections from ventral group inspiratory neurons to phrenic motoneurons in the rat determined by cross-correlation

1995 ◽  
Vol 694 (1-2) ◽  
pp. 55-60 ◽  
Author(s):  
James Duffin ◽  
Jane van Alphen
Keyword(s):  
Cross Correlation ◽  
Phrenic Motoneurons ◽  
Inspiratory Neurons

Projections from inspiratory neurons of the nucleus retroambigualis to phrenic motoneurons in the cat

1989 ◽  
Vol 105 (3) ◽  
pp. 306-310 ◽  
Author(s):  
L. Fedorko ◽  
R.W. Hoskin ◽  
J. Duffin
Keyword(s):  
Phrenic Motoneurons ◽  
Inspiratory Neurons

Case Formulation and Design of Behavioral Treatment Programs

2003 ◽  
Vol 19 (3) ◽  
pp. 164-174 ◽  
Author(s):  
Stephen N. Haynes ◽  
Andrew E. Williams
Keyword(s):  
Functional Analysis ◽  
Behavior Problems ◽  
Behavioral Treatment ◽  
Clinical Case ◽  
Relative Magnitude ◽  
Mechanisms Of Action ◽  
Treatment Programs ◽  
Case Formulation ◽  
Functional Relations ◽  
Causal Variables

Summary: We review the rationale for behavioral clinical case formulations and emphasize the role of the functional analysis in the design of individualized treatments. Standardized treatments may not be optimally effective for clients who have multiple behavior problems. These problems can affect each other in complex ways and each behavior problem can be influenced by multiple, interacting causal variables. The mechanisms of action of standardized treatments may not always address the most important causal variables for a client's behavior problems. The functional analysis integrates judgments about the client's behavior problems, important causal variables, and functional relations among variables. The functional analysis aids treatment decisions by helping the clinician estimate the relative magnitude of effect of each causal variable on the client's behavior problems, so that the most effective treatments can be selected. The parameters of, and issues associated with, a functional analysis and Functional Analytic Clinical Case Models (FACCM) are illustrated with a clinical case. The task of selecting the best treatment for a client is complicated because treatments differ in their level of specificity and have unequally weighted mechanisms of action. Further, a treatment's mechanism of action is often unknown.

Diagnostics of perfusion-functional relations in lacrimal gland pathology

Reflection ◽  
2018 ◽  
Vol 6 (1) ◽  
pp. 188-193
Author(s):  
Y. V. Falina ◽  
◽  
V. A. Obodov ◽  
V. V. Pankin ◽  
A. A. Smirnov ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Functional Relations

scholarly journals Characterization of Gas Transport Properties of Compacted Solid Waste Materials

Environments ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 26
Author(s):  
Muhammad Rashid Iqbal ◽  
Hiniduma Liyanage Damith Nandika ◽  
Yugo Isobe ◽  
Ken Kawamoto
Keyword(s):  
Hydraulic Conductivity ◽  
Solid Waste ◽  
Gas Transport ◽  
Bottom Ash ◽  
Gas Diffusion ◽  
Saturated Hydraulic Conductivity ◽  
Dry Density ◽  
Transport Parameters ◽  
Functional Relations ◽  
Mixed Waste

Gas transport parameters such as gas diffusivity (Dp/D0), air permeability (ka), and their dependency on void space (air-filled porosity, ε) in a waste body govern convective air and gas diffusion at solid waste dumpsites and surface emission of various gases generated by microbial processes under aerobic and anaerobic decompositions. In this study, Dp/D0(ε) and ka(ε) were measured on dumping solid waste in Japan such as incinerated bottom ash and unburnable mixed waste as well as a buried waste sample (dumped for 20 years). Sieved samples with variable adjusted moistures were compacted by a standard proctor method and used for a series of laboratory tests for measuring compressibility, saturated hydraulic conductivity, and gas transport parameters. Results showed that incinerated bottom ash and unburnable mixed waste did not give the maximum dry density and optimum moisture content. Measured compressibility and saturated hydraulic conductivity of tested samples varied widely depending on the types of materials. Based on the previously proposed Dp/D0(ε) models, the diffusion-based tortuosity (T) was analyzed and unique power functional relations were found in T(ε) and could contribute to evaluating the gas diffusion process in the waste body compacted at different moisture conditions.

Physiological Properties of Late Inspiratory Neurons and Their Possible Involvement in Inspiratory Off-Switching in Cats

2002 ◽  
Vol 87 (2) ◽  
pp. 1057-1067 ◽  
Author(s):  
Akira Haji ◽  
Mari Okazaki ◽  
Hiromi Yamazaki ◽  
Ryuji Takeda
Keyword(s):  
Nmda Receptors ◽  
Gaba Release ◽  
Membrane Depolarization ◽  
Inhibitory Neurons ◽  
Acid Decarboxylase ◽  
Postsynaptic Potentials ◽  
Inspiratory Neurons ◽  
Small Constant ◽  
Physiological Properties ◽  
Decerebrate Cats

To assess the functional significance of late inspiratory (late-I) neurons in inspiratory off-switching (IOS), membrane potential and discharge properties were examined in vagotomized, decerebrate cats. During spontaneous IOS, late-I neurons displayed large membrane depolarization and associated discharge of action potentials that started in late inspiration, peaked at the end of inspiration, and ended during postinspiration. Depolarization was decreased by iontophoresis of dizocilpine and eliminated by tetrodotoxin. Stimulation of the vagus nerve or the nucleus parabrachialis medialis (NPBM) also evoked depolarization of late-I neurons and IOS. Waves of spontaneous chloride-dependent inhibitory postsynaptic potentials (IPSPs) preceded membrane depolarization during early inspiration and followed during postinspiration and stage 2 expiration of the respiratory cycle. Iontophoresed bicuculline depressed the IPSPs. Intravenous dizocilpine caused a greatly prolonged inspiratory discharge of the phrenic nerve (apneusis) and suppressed late-inspiratory depolarization as well as early-inspiratory IPSPs, resulting in a small constant depolarization throughout the apneusis. NPBM or vagal stimulation after dizocilpine produced small, stimulus-locked excitatory postsynaptic potentials (EPSPs) in late-I neurons. Neurobiotin-labeled late-I neurons revealed immunoreactivity for glutamic acid decarboxylase as well as N-methyl-d-aspartate (NMDA) receptors. These results suggest that late-I neurons are GABAergic inhibitory neurons, while the effects of bicuculline and dizocilpine indicate that they receive periodic waves of GABAergic IPSPs and glutamatergic EPSPs. The data lead to the conclusion that late-I neurons play an important inhibitory role in IOS. NMDA receptors are assumed to augment and/or synchronize late-inspiratory depolarization and discharge of late-I neurons, leading to GABA release and consequently off-switching of bulbar inspiratory neurons and phrenic motoneurons.

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