Effect of Aging on the ß-Adrenergic Signal Transduction System in Rat Kidney, Lung, and Mononuclear Leukocytes

1991 ◽  
pp. 193-206 ◽  
Author(s):  
N. Fraeyman ◽  
E. Van de Velde ◽  
P. Vanscheeuwijck
Keyword(s):  
Signal Transduction ◽  
Rat Kidney ◽  
Mononuclear Leukocytes ◽  
Signal Transduction System

Effect of maturation and aging on β-adrenergic signal transduction in rat kidney and liver

2000 ◽  
Vol 60 (12) ◽  
pp. 1787-1795 ◽  
Author(s):  
Norbert Fraeyman ◽  
Eric Van de Velde ◽  
Ann Van Ermen ◽  
Ariane Bazan ◽  
Patrick Vanderheyden ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Rat Kidney

scholarly journals Dissection of a Hypoxia-induced, Nitric Oxide–mediated Signaling Cascade

2009 ◽  
Vol 20 (18) ◽  
pp. 4083-4090 ◽  
Author(s):  
Pascale F. Dijkers ◽  
Patrick H. O'Farrell
Keyword(s):  
Nitric Oxide ◽  
Signal Transduction ◽  
Signaling Cascade ◽  
S2 Cells ◽  
Signal Transduction System ◽  
Signaling Systems ◽  
Calcium Dependent ◽  
Drosophila S2 Cells ◽  
Oxide Synthase ◽  
Multiple Signaling

Befitting oxygen's key role in life's processes, hypoxia engages multiple signaling systems that evoke pervasive adaptations. Using surrogate genetics in a powerful biological model, we dissect a poorly understood hypoxia-sensing and signal transduction system. Hypoxia triggers NO-dependent accumulation of cyclic GMP and translocation of cytoplasmic GFP-Relish (an NFκB/Rel transcription factor) to the nucleus in Drosophila S2 cells. An enzyme capable of eliminating NO interrupted signaling specifically when it was targeted to the mitochondria, arguing for a mitochondrial NO signal. Long pretreatment with an inhibitor of nitric oxide synthase (NOS), L-NAME, blocked signaling. However, addition shortly before hypoxia was without effect, suggesting that signaling is supported by the prior action of NOS and is independent of NOS action during hypoxia. We implicated the glutathione adduct, GSNO, as a signaling mediator by showing that overexpression of the cytoplasmic enzyme catalyzing its destruction, GSNOR, blocks signaling, whereas knockdown of this activity caused reporter translocation in the absence of hypoxia. In downstream steps, cGMP accumulated, and calcium-dependent signaling was subsequently activated via cGMP-dependent channels. These findings reveal the use of unconventional steps in an NO pathway involved in sensing hypoxia and initiating signaling.

Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system

2018 ◽  
Vol 11 (525) ◽  
pp. eaaq0825 ◽  
Author(s):  
Gareth S. A. Wright ◽  
Akane Saeki ◽  
Takaaki Hikima ◽  
Yoko Nishizono ◽  
Tamao Hisano ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Oxygen Sensing ◽  
Signal Transduction System ◽  
Two Component ◽  
Two Component Signal Transduction

scholarly journals Characterization of changes of pain behavior and signal transduction system in food-deprived mice

2018 ◽  
Vol 22 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Sang-Pil Jang ◽  
Seong-Hwan Park ◽  
Jun-Sub Jung ◽  
Hee-Jung Lee ◽  
Jung-Woo Hong ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Pain Behavior ◽  
Signal Transduction System
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