Comparable Inhibitory Action of PGE1 and 13,14-dihydro-PGE1 on Smooth Muscle Cell Activity and Extracellular Matrix Production

1991 ◽  
pp. 33-38
Author(s):  
I. Neumann ◽  
P. Fitscha ◽  
J. O’grady ◽  
B. A. Peskar ◽  
H. Sinzinger
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Inhibitory Action ◽  
Cell Activity ◽  
Extracellular Matrix Production ◽  
Matrix Production

Impact of Endothelial Cells and Mechanical Conditioning on Smooth Muscle Cell Extracellular Matrix Production and Differentiation

2009 ◽  
Vol 15 (4) ◽  
pp. 815-825 ◽  
Author(s):  
Allen S. Bulick ◽  
Dany J. Muñoz-Pinto ◽  
Xin Qu ◽  
Mousami Mani ◽  
Deissy Cristancho ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Mechanical Conditioning ◽  
Extracellular Matrix Production ◽  
Matrix Production

Extracellular matrix control of smooth muscle cell activity

1993 ◽  
pp. 364-370
Author(s):  
M. Thie ◽  
B. Harrach ◽  
B. Redecker ◽  
J. Rauterberg ◽  
H. Robenek
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Activity ◽  
Matrix Control

scholarly journals Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification

2009 ◽  
Vol 21 (1) ◽  
pp. 103-112 ◽  
Author(s):  
Rukshana C. Shroff ◽  
Rosamund McNair ◽  
Jeremy N. Skepper ◽  
Nichola Figg ◽  
Leon J. Schurgers ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Adaptation

scholarly journals In Silico Prediction of the Mechanobiological Response of Arterial Tissue: Application to Angioplasty and Stenting

2011 ◽  
Vol 133 (8) ◽  
Author(s):  
Colin J. Boyle ◽  
Alexander B. Lennon ◽  
Patrick J. Prendergast
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Time Course ◽  
Neointimal Hyperplasia ◽  
Cell Activity ◽  
Tissue Response ◽  
Cell Phenotype ◽  
Modeling Approach ◽  
Arterial Tissue

One way to restore physiological blood flow to occluded arteries involves the deformation of plaque using an intravascular balloon and preventing elastic recoil using a stent. Angioplasty and stent implantation cause unphysiological loading of the arterial tissue, which may lead to tissue in-growth and reblockage; termed “restenosis.” In this paper, a computational methodology for predicting the time-course of restenosis is presented. Stress-induced damage, computed using a remaining life approach, stimulates inflammation (production of matrix degrading factors and growth stimuli). This, in turn, induces a change in smooth muscle cell phenotype from contractile (as exists in the quiescent tissue) to synthetic (as exists in the growing tissue). In this paper, smooth muscle cell activity (migration, proliferation, and differentiation) is simulated in a lattice using a stochastic approach to model individual cell activity. The inflammation equations are examined under simplified loading cases. The mechanobiological parameters of the model were estimated by calibrating the model response to the results of a balloon angioplasty study in humans. The simulation method was then used to simulate restenosis in a two dimensional model of a stented artery. Cell activity predictions were similar to those observed during neointimal hyperplasia, culminating in the growth of restenosis. Similar to experiment, the amount of neointima produced increased with the degree of expansion of the stent, and this relationship was found to be highly dependant on the prescribed inflammatory response. It was found that the duration of inflammation affected the amount of restenosis produced, and that this effect was most pronounced with large stent expansions. In conclusion, the paper shows that the arterial tissue response to mechanical stimulation can be predicted using a stochastic cell modeling approach, and that the simulation captures features of restenosis development observed with real stents. The modeling approach is proposed for application in three dimensional models of cardiovascular stenting procedures.

scholarly journals A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy

2011 ◽  
Vol 54 (1) ◽  
pp. 182-191.e24 ◽  
Author(s):  
Richard D. Kenagy ◽  
Seung-Kee Min ◽  
Eileen Mulvihill ◽  
Alexander W. Clowes
Keyword(s):  
Extracellular Matrix ◽  
Cell Death ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Matrix Degradation ◽  
Extracellular Matrix Degradation

HSP70 increases extracellular matrix production by human vascular smooth muscle through TGF-β1 up-regulation

2013 ◽  
Vol 45 (2) ◽  
pp. 232-242 ◽  
Author(s):  
Marta González-Ramos ◽  
Laura Calleros ◽  
Susana López-Ongil ◽  
Viviana Raoch ◽  
Mercedes Griera ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Extracellular Matrix Production ◽  
Matrix Production ◽  
Tgf Β1
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