Impact of Endothelial Cells and Mechanical Conditioning on Smooth Muscle Cell Extracellular Matrix Production and Differentiation

2009 ◽  
Vol 15 (4) ◽  
pp. 815-825 ◽  
Author(s):  
Allen S. Bulick ◽  
Dany J. Muñoz-Pinto ◽  
Xin Qu ◽  
Mousami Mani ◽  
Deissy Cristancho ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Mechanical Conditioning ◽  
Extracellular Matrix Production ◽  
Matrix Production

scholarly journals Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification

2009 ◽  
Vol 21 (1) ◽  
pp. 103-112 ◽  
Author(s):  
Rukshana C. Shroff ◽  
Rosamund McNair ◽  
Jeremy N. Skepper ◽  
Nichola Figg ◽  
Leon J. Schurgers ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Adaptation

Cyclic strain induces expression of specific smooth muscle cell markers in human endothelial cells

2006 ◽  
Vol 74 (9-10) ◽  
pp. 552-561 ◽  
Author(s):  
Manuel Cevallos ◽  
Gordon M. Riha ◽  
Xinwen Wang ◽  
Hui Yang ◽  
Shaoyu Yan ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cyclic Strain ◽  
Human Endothelial Cells ◽  
Cell Markers

scholarly journals A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy

2011 ◽  
Vol 54 (1) ◽  
pp. 182-191.e24 ◽  
Author(s):  
Richard D. Kenagy ◽  
Seung-Kee Min ◽  
Eileen Mulvihill ◽  
Alexander W. Clowes
Keyword(s):  
Extracellular Matrix ◽  
Cell Death ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Matrix Degradation ◽  
Extracellular Matrix Degradation

HSP70 increases extracellular matrix production by human vascular smooth muscle through TGF-β1 up-regulation

2013 ◽  
Vol 45 (2) ◽  
pp. 232-242 ◽  
Author(s):  
Marta González-Ramos ◽  
Laura Calleros ◽  
Susana López-Ongil ◽  
Viviana Raoch ◽  
Mercedes Griera ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Extracellular Matrix Production ◽  
Matrix Production ◽  
Tgf Β1

scholarly journals Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Maarten M. Brandt ◽  
Christian G. M. van Dijk ◽  
Ranganath Maringanti ◽  
Ihsan Chrifi ◽  
Rafael Kramann ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Microvascular Endothelial Cell ◽  
Human Endothelial Cells ◽  
Morphological Adaptation ◽  
Tgfβ Signaling ◽  
Adaptation Pathway ◽  
Extracellular Matrix Production ◽  
Matrix Production

Abstract Microvascular homeostasis is strictly regulated, requiring close interaction between endothelial cells and pericytes. Here, we aimed to improve our understanding of how microvascular crosstalk affects pericytes. Human-derived pericytes, cultured in absence, or presence of human endothelial cells, were studied by RNA sequencing. Compared with mono-cultured pericytes, a total of 6704 genes were differentially expressed in co-cultured pericytes. Direct endothelial contact induced transcriptome profiles associated with pericyte maturation, suppression of extracellular matrix production, proliferation, and morphological adaptation. In vitro studies confirmed enhanced pericyte proliferation mediated by endothelial-derived PDGFB and pericyte-derived HB-EGF and FGF2. Endothelial-induced PLXNA2 and ACTR3 upregulation also triggered pericyte morphological adaptation. Pathway analysis predicted a key role for TGFβ signaling in endothelial-induced pericyte differentiation, whereas the effect of signaling via gap- and adherens junctions was limited. We demonstrate that endothelial cells have a major impact on the transcriptional profile of pericytes, regulating endothelial-induced maturation, proliferation, and suppression of ECM production.

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