A New In Vitro Test System and Phototoxicological Studies on Cell Cultures Based on the Melamine Substrate Foil

1993 ◽  
pp. 324-333
Author(s):  
C. Westphal Frösch ◽  
A. Rück
Keyword(s):  
Cell Cultures ◽  
Test System ◽  
In Vitro Test ◽  
Vitro Test

In vitro test system for compounds affecting cholesterol pathway: Studies in primary rat liver cell cultures

1988 ◽  
Vol 1 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Johannes Pill ◽  
Johannes Aufenanger ◽  
Barbara Frey ◽  
Albrecht Frey ◽  
Gisela Johne ◽  
...  
Keyword(s):  
Rat Liver ◽  
Cell Cultures ◽  
Liver Cell ◽  
Test System ◽  
In Vitro Test ◽  
Vitro Test

An in vitro test system for compounds that modulate human inflammatory macrophage polarization

2018 ◽  
Vol 833 ◽  
pp. 328-338 ◽  
Author(s):  
Hiromi Shiratori ◽  
Carmen Feinweber ◽  
Sonja Luckhardt ◽  
Nadja Wallner ◽  
Gerd Geisslinger ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Test System ◽  
In Vitro Test ◽  
Vitro Test ◽  
Inflammatory Macrophage

Biomimetic in vitro test system for evaluation of dental implant materials

2020 ◽  
Vol 36 (8) ◽  
pp. 1059-1070
Author(s):  
Franziska Ehlicke ◽  
Jonathan Berndt ◽  
Nina Marichikj ◽  
Doris Steinmüller-Nethl ◽  
Heike Walles ◽  
...  
Keyword(s):  
Dental Implant ◽  
Test System ◽  
In Vitro Test ◽  
Implant Materials ◽  
Vitro Test

scholarly journals Prediction of in Vivo Cytotoxicity of Chemotherapeutic Agents by Their Effect on Malignant Leukocytes in Vitro

Blood ◽  
1967 ◽  
Vol 30 (2) ◽  
pp. 176-188 ◽  
Author(s):  
MARTIN J. CLINE
Keyword(s):  
Test System ◽  
Chemotherapeutic Agents ◽  
Response To Treatment ◽  
In Vitro Test ◽  
Malignant Cells ◽  
Vitro Test ◽  
In Vitro Effects ◽  
In Vivo Cytotoxicity

Abstract In order to develop a test system for predicting the response to chemotherapeutic agents, leukocytes from patients with leukemia and leukolymphosarcoma were cultured in vitro and the effect of several drugs on the incorporation of H3-uridine into ribonucleic acid was measured. Cortisol, vincristine and cytosine arabinoside at concentrations near the therapeutic range produced inhibition of H3-uridine incorporation in sensitive leukocytes. The in vitro effects of 6-mercaptopurine and methotrexate were variable. In 39 trials on 25 patients with leukemia or lymphosarcoma, the in vitro test was used successfully to predict the response to treatment with prednisone and vincristine. It was concluded that the in vitro test system can predict the in vivo cytotoxicity of certain drugs for malignant cells, although it cannot be used to predict the likelihood of the induction of remissions with these drugs.

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