Clinical and Immunological Recovery of Children with Acute Lymphocytic Leukemia Admitted to “Total Therapy” Studies

1973 ◽  
pp. 145-150 ◽  
Author(s):  
L. Borella ◽  
A. A. Green ◽  
R. J. A. Aur ◽  
J. V. Simone ◽  
D. Pinkel
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Immunological Recovery ◽  
Total Therapy ◽  
Therapy Studies

Total therapy of acute lymphocytic leukemia

JAMA ◽  
1972 ◽  
Vol 222 (9) ◽  
pp. 1170-1170 ◽  
Author(s):  
D. Pinkel
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Total Therapy

NINE YEARS' EXPERIENCE WITH "TOTAL THERAPY" OF CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA

PEDIATRICS ◽  
1972 ◽  
Vol 50 (2) ◽  
pp. 246-251
Author(s):  
Donald Pinkel ◽  
Joseph Simone ◽  
H. Omar Hustu ◽  
Rhomes J. A. Aur
Keyword(s):  
High Frequency ◽  
Acute Lymphocytic Leukemia ◽  
Cranial Irradiation ◽  
Lymphocytic Leukemia ◽  
Intrathecal Methotrexate ◽  
Combined Chemotherapy ◽  
Incurable Disease ◽  
The Central Nervous System ◽  
Total Therapy ◽  
Hematological Remission

Experience with combined chemotherapy and radiotherapy of acute lymphocytic leukemia (ALL) in children is reviewed. Multiple anti-metabolite chemotherapy is effective in prolonging duration of continuous hematological remission. Craniospinal irradiation or cranial irradiation combined with intrathecal methotrexate in adequate doses inhibits relapse in the central nervous system. The high frequency of lengthy continuous complete remission achieved with "total therapy" indicates that ALL in children cannot be considered an incurable disease. Palliation is no longer an acceptable approach to its initial treatment.

scholarly journals “Total therapy” of childhood acute lymphocytic leukemia

1971 ◽  
Vol 5 (8) ◽  
pp. 408-408
Author(s):  
Donald P Pinkel ◽  
Joseph V Simone ◽  
H Omar Hustu ◽  
Rhomes J
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Total Therapy

Motility of leukemic lymphocytes

1990 ◽  
Vol 48 (3) ◽  
pp. 368-369
Author(s):  
Manoj Raje ◽  
Karvita B. Ahluwalia
Keyword(s):  
Quantitative Data ◽  
Laser Doppler Velocimetry ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Cellular Space ◽  
Differentiated Cells ◽  
Poorly Differentiated ◽  
Solid Tissues ◽  
Well Differentiated ◽  
Reduced Mobility

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia

2001 ◽  
Vol 2 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Simone Boehrer ◽  
Kai U Chow ◽  
Elena Puccetti ◽  
Martin Ruthardt ◽  
Shahrzad Godzisard ◽  
...  
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Response Gene ◽  
Gene 4

New Therapeutic Approach to Reduce Methotrexate Toxicity after High-Dose Chemotherapy in a Child with Acute Lymphocytic Leukemia: Efficacy and Safety of Hemoadsorption with HA-230 Adsorber

2021 ◽  
pp. 1-5
Author(s):  
Vitaliy Sazonov ◽  
Zaure Tobylbayeva ◽  
Askhat Saparov ◽  
Bolatbek Jubaniyazov ◽  
Samat Issakov ◽  
...  
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Pediatric Patients ◽  
High Dose Chemotherapy ◽  
The Body ◽  
Lymphocytic Leukemia ◽  
High Dose ◽  
Successful Implementation ◽  
Efficacy And Safety ◽  
Related Complication ◽  
Dose Methotrexate

Background: High-dose methotrexate (HDMTX) is likely to cause a number of side effects and manifest itself as hepatotoxicity, nephrotoxicity, mucositis, and neurotoxicity. A several studies demonstrated the efficacy of extracorporeal detoxification methods such as plasma exchange, hemodialysis (HD), HD filtration, and hemoperfusion for the treatment of MTX delayed clearance. However, none of the existing methods as effective as expected and limited for general implementation due to a procedure-related complication. Case Report: Here, we report a successful implementation of HA-230 hemoadsorption procedure to remove cumulated MTX from the body and reduce its toxicity in a child with ALL after high-dose chemotherapy. Results and Conclusion: Based on our results, single-hemoadsorption procedure with the HA-230 adsorber in case of delayed methotrexate clearance was safe and well-tolerated in a pediatric patient with ALL and would significantly improve the patient’s condition. Further studies need to demonstrate its safety and efficacy in a large number of pediatric patients.

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