5-Fluorouracil Versus a Combination of BCNU, Adriamycin, 5- FU and Mitomycin C in Advanced Gastric Cancer: A Prospective Randomized Study of the Italian Clinical Research Oncology Group

1988 ◽  
pp. 212-218 ◽  
Author(s):  
V. De Lisi ◽  
G. Cocconi ◽  
M. Tonato ◽  
F. Di Costanzo ◽  
F. Leonardi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Research ◽  
Advanced Gastric Cancer ◽  
Mitomycin C ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Oncology Group

scholarly journals A Cooperative Randomized Study on Tegafur plus Mitomycin C versus Combined Tegafur and Uracil plus Mitomycin C in the Treatment of Advanced Gastric Cancer

1991 ◽  
Vol 82 (5) ◽  
pp. 613-620 ◽  
Author(s):  
Minoru Kurihara ◽  
Tuguhiko Izumi ◽  
Shigeaki Yoshida ◽  
Toshiharu Ohkubo ◽  
Shoji Suga ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Mitomycin C ◽  
Randomized Study

A Prospective Randomized Study Comparing Open versus Laparoscopy-Assisted D2 Radical Gastrectomy in Advanced Gastric Cancer

2011 ◽  
Vol 28 (5-6) ◽  
pp. 331-337 ◽  
Author(s):  
J. Cai ◽  
D. Wei ◽  
C.F. Gao ◽  
C.S. Zhang ◽  
H. Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Radical Gastrectomy ◽  
Open Versus

scholarly journals Evaluation of the efficacy and toxicity of protocol cisplatin, 5-fluorouracil, leucovorin compared to protocol fluorouracil, doxorubicin and mitomycin C in locally advanced and metastatic gastric cancer

2012 ◽  
Vol 140 (5-6) ◽  
pp. 305-312 ◽  
Author(s):  
Zoran Andric ◽  
Tomislav Randjelovic ◽  
Vladimir Kovcin ◽  
Jasmina Gutovic ◽  
Slobodanka Crevar ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Mitomycin C ◽  
Randomized Study ◽  
Locally Advanced ◽  
Progression Free Survival ◽  
Metastatic Gastric Cancer ◽  
Rank Test ◽  
Significant Difference ◽  
New Strategies

Introduction. Still there is no consensus on the choice of the most efficient and the least toxic chemotherapy regimen in the treatment of advanced gastric cancer. Nowadays few therapy protocols are available for treating this disease. Objective. Study was conducted to compare the efficacy and toxicity of FAM (flurouracil, doxorubicin, mitomycin C) with CDDP and FU/FA (cisplatin, 5-fluorouracil, leucovorin) protocols in patients with locally advanced and metastatic gastric cancer. Methods. This randomized study involved a group of 50 patients with locally advanced or metastatic gastric cancer, who had not previously undergone chemotherapy treatment. Progression free survival, overall survival and drug toxicity were evaluated. For statistical analysis chi-square test, Kaplan-Meier curve and the log rank test were used. Results. The overall response rate was 20% in the group treated with FAM and 24% in the group treated with CDDP, FU/FA (4% of patients from each group had complete response), but without significant statistical difference. Median survival was 10.9 months in the FAM group and 11.8 months in CDDP, FU/FA group, with no statistically significant difference. Non-haematological and haematological toxicities of CDDP, FU/FA were considerably less frequent than of FAM, and there was no treatment related deaths in any of the groups. Conclusion. Both investigated regimens demonstrated moderate efficacy. The study shows in favour of justified application of both protocols, while in regard to toxicity CDDP and FU/FA can be recommended as preferable treatment for locally advanced and metastatic gastric cancer. New strategies should be considered for better efficacy in the treatment of advanced gastric cancer. New strategies are necessary with the goal to achieve a better therapeutic effect.

Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study

2013 ◽  
Vol 20 (12) ◽  
pp. 3912-3918 ◽  
Author(s):  
Luigi Marano ◽  
Raffaele Porfidia ◽  
Modestino Pezzella ◽  
Michele Grassia ◽  
Marianna Petrillo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Total Gastrectomy ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Gastric Cancer Patients
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