The Role of Lipid Peroxidation in Ischemic Central Nervous System Injury

1989 ◽  
pp. 49-65
Author(s):  
E. D. Means ◽  
J. M. Braughler ◽  
E. D. Hall
Keyword(s):  
Lipid Peroxidation ◽  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Injury

The Neuroprotective Role of Reactive Astrocytes after Central Nervous System Injury

2020 ◽  
Vol 37 (5) ◽  
pp. 681-691 ◽  
Author(s):  
Anthony George Boghdadi ◽  
Leon Teo ◽  
James Andrew Bourne
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Injury ◽  
Reactive Astrocytes

Role of Wnt Signaling in Central Nervous System Injury

2015 ◽  
Vol 53 (4) ◽  
pp. 2297-2311 ◽  
Author(s):  
Catherine Lambert ◽  
Pedro Cisternas ◽  
Nibaldo C. Inestrosa
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Wnt Signaling ◽  
Central Nervous System Injury

scholarly journals Role of Agmatine on Neuroglia in Central Nervous System Injury

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Sumit Barua ◽  
Jong Youl Kim ◽  
Jong Eun Lee
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Injury

scholarly journals Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases

2021 ◽  
Vol 22 (18) ◽  
pp. 9902
Author(s):  
Xintong Wang ◽  
Zixu Wang ◽  
Jing Cao ◽  
Yulan Dong ◽  
Yaoxing Chen
Keyword(s):  
Lipid Peroxidation ◽  
Central Nervous System ◽  
Cell Death ◽  
Nervous System ◽  
Glutathione Metabolism ◽  
Intracellular Iron ◽  
System Disease ◽  
And Function ◽  
The Brain

Ferroptosis is a newly recognized type of cell death that is different from traditional forms of cell death, such as apoptosis, autophagy, and necrosis. It is caused by the accumulation of intracellular iron, promoting lipid peroxidation and leading to cell death. Iron is essential as a redox metal in several physiological functions. The brain is one of the organs known to be affected by iron homeostatic balance disruption. An increased concentration of iron in the central nervous system has been associated with oxidative stress, lipid peroxidation of proteins, and cell death. The hippocampus is an important brain region for learning, memory, and emotional responses, and is also a sensitive part of the brain to the dysfunctional homeostasis of transition metals. Damage of hippocampal structure and function are intimately involved in the pathogenic mechanisms underlying neurodegenerative diseases. Currently, ferroptosis is playing an increasingly important role in treatment areas of central nervous system diseases. Thus, we provide an overview of ferroptosis regulatory mechanisms, such as lipid metabolism, glutathione metabolism, and iron metabolism in this review. We also highlight the role of ferroptosis in hippocampal-related diseases and investigate a theoretical basis for further research on the role of ferroptosis in nervous system disease treatment.

Role of connexin43 in central nervous system injury

2010 ◽  
Vol 225 (2) ◽  
pp. 250-261 ◽  
Author(s):  
Shenton S.L. Chew ◽  
Cameron S. Johnson ◽  
Colin R. Green ◽  
Helen V. Danesh-Meyer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Injury
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