Capillary density and oxygen supply in human dilated cardiomyopathy

1988 ◽  
pp. 255-259 ◽  
Author(s):  
H. R. Figulla ◽  
F. Vetterlein ◽  
V. Wiegand ◽  
S. Schüler ◽  
H. Kreuzer
Keyword(s):  
Dilated Cardiomyopathy ◽  
Oxygen Supply ◽  
Capillary Density

scholarly journals Upregulation of VEGF-A Without Angiogenesis in a Mouse Model of Dilated Cardiomyopathy Caused by Mitochondrial Dysfunction

2002 ◽  
Vol 50 (7) ◽  
pp. 935-944 ◽  
Author(s):  
Emma Tham ◽  
Jianming Wang ◽  
Fredrik Piehl ◽  
Günther Weber
Keyword(s):  
Transcription Factor ◽  
Dilated Cardiomyopathy ◽  
Capillary Density ◽  
Vascular Endothelial ◽  
Protein Levels ◽  
Mitochondrial Transcription Factor ◽  
Mitochondrial Transcription Factor A ◽  
Respiratory Chain Activity ◽  
Endothelial Growth Factor

Angiogenesis is implicated in a variety of human pathologies and may also play a role in the progression of heart failure. We have studied the expression of members of the vascular endothelial growth factor (VEGF) and the angiopoietin families and their receptors in mice lacking the mitochondrial transcription factor A. These mice lack functional respiratory chain activity in their myocytes and develop dilated cardiomyopathy (DCM) postnatally. We studied the hearts of the knockout mice by in situ hybridization, Western blotting analysis, and immunohistochemistry. VEGF-A mRNA and protein levels were elevated in the myocardium of the knockouts. Levels of the hypoxia inducible transcription factor 1 alpha (HIF1α) and of glyceraldehyde-3-phosphate dehydrogenase transcripts were also increased, whereas those of angiopoietin−1 and −2 were reduced. Despite the striking upregulation of VEGF-A, there was no increase in capillary density in the knockout hearts. This study suggests that a disturbance in angiogenesis may contribute to the pathogenesis of DCM.

Capillary density in mammals in relation to body size and oxygen consumption

1961 ◽  
Vol 200 (4) ◽  
pp. 746-750 ◽  
Author(s):  
Knut Schmidt-Nielsen ◽  
Pamela Pennycuik
Keyword(s):  
Oxygen Consumption ◽  
Body Size ◽  
Small Mammals ◽  
Oxygen Delivery ◽  
Oxygen Supply ◽  
Size Range ◽  
Small Animal ◽  
Capillary Density ◽  
High Rate ◽  
High Metabolic Rate

The high metabolic rate per gram of tissue in small mammals requires that oxygen be supplied to the tissues at a higher rate than in larger animals. The high rate of oxygen delivery in the small animal can be accomplished by a) higher capillary density and b) higher unloading tension for oxygen. Both these factors in the oxygen supply vary with body size in such a manner that delivery of oxygen to the tissues is facilitated in the small animal. This paper gives comparative data on capillary density in muscles from 10 mammals of various size. The smallest mammals have significantly higher capillary densities, but the trend is not evident throughout the size range examined. It is therefore reasonable to assume that the factors that relate capillary density and body size are overshadowed by variables such as activity, domestication, cold acclimation, etc., and, perhaps primarily, the size of the muscle fibers, which (although dependent on body size) varies considerably with the type of muscle and its use.

Microvascular adaptations during maturation of striated muscle

1981 ◽  
Vol 241 (3) ◽  
pp. H317-H324 ◽  
Author(s):  
I. H. Sarelius ◽  
D. N. Damon ◽  
B. R. Duling
Keyword(s):  
Oxygen Supply ◽  
Striated Muscle ◽  
Important Determinant ◽  
Capillary Density ◽  
Cremaster Muscle ◽  
Tissue Oxygen ◽  
Functional Reserve ◽  
Parallel Pattern ◽  
Muscle Changes ◽  
Tissue Oxygen Supply

It is well known that capillary density in striated muscle changes during maturation. Capillary density is an important determinant of tissue oxygen supply, the other principal determinants being capillary erythrocyte flow and capillary hematocrit. The microcirculation of the hamster cremaster muscle was studied at different stages of development. We found that the microcirculation of juvenile animals was characterized by small intercapillary distances, short capillary lengths, and tortuous vessels. During maturation, the capillaries elongated and developed the more “typical” parallel pattern. Capillary density decreased from 1,626 +/- 60 capillaries . mm-3 at 35 days of age to 696 +/- 65 capillaries . mm-3 at 132 days; erythrocyte flow per capillary decreased from 1,441 +/- 135 to 583 +/- 47 micrometers 3 . s-1; and capillary hematocrit decreased from 21.5 +/- 0.7 to 14.6 +/- 0.6%. Concomitant with these decreases, the functional reserve increased; in adult muscles, capillary density could increase by 42%, erythrocyte flow per capillary by 457.2%, and capillary hematocrit by 112.4%, compared with 7.7, 20.3, and 24.1%, respectively, in immature animals. These observations show that age significantly modifies microvascular parameters related to tissue oxygen supply and provides an explanation for some conflicting observations in the literature.

Studies on Ultrastructure and Cytochemistry of Right Ventricular Endomyocardial Biopsy

1990 ◽  
Vol 48 (3) ◽  
pp. 256-257
Author(s):  
Xia Mingyu ◽  
Ma Wengshu ◽  
Wu Xiangh ◽  
Chen Dong
Keyword(s):  
Light Microscopy ◽  
Right Ventricular ◽  
Dilated Cardiomyopathy ◽  
Endomyocardial Biopsy ◽  
Heart Diseases ◽  
Ultrastructural Localization ◽  
Controlled Study ◽  
Myocardial Biopsy ◽  
Morphological Assessment ◽  
Rheumatic Heart

This paper describes morphological and cytochemistry changes of endomyocardial biopsy in 94 patients. The samples of myoicardium were taken from 32 patients with dilated cardiomyopathy, and sdudied with light and electron microscop. The cytochemical studies in some of these patients were performed at histological and ultrastructure level. This paper also reported the result of myocardial biopsy in 33 patients with serious dysrythmia.The result of this controlled study indicates that morphological assessment in both cardiomyopathy and congenital or rheumatic heart diseases showed no special changes. In patients of dilated cardiomyopathy, the decreased activity of myosin ATPase was secondary to cardial failure. The change of succinate dehydrogenase (SDHase) was not significant with light microscopy. But ultrastructural localization of SDHase activity is valuable. Its activity was found to be localized in endomembrane and ridge of the mitochondria, the activity of this enzyme was decrease, normal, or increase. SDHase activity was more intense in cardial myocytes well-functioning, or ultrastructurally well preserved hearts.

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