Skeletal Myogenesis in the Zebrafish and Its Implications for Muscle Disease Modelling

2014 ◽  
pp. 49-76 ◽  
Author(s):  
David Gurevich ◽  
Ashley Siegel ◽  
Peter D. Currie
Keyword(s):  
Muscle Disease ◽  
Disease Modelling ◽  
Skeletal Myogenesis

scholarly journals The transcription coactivator ASC-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease

2016 ◽  
Vol 25 (8) ◽  
pp. 1559-1573 ◽  
Author(s):  
Laurianne Davignon ◽  
Claire Chauveau ◽  
Cédric Julien ◽  
Corinne Dill ◽  
Isabelle Duband-Goulet ◽  
...  
Keyword(s):  
Muscle Disease ◽  
Skeletal Myogenesis ◽  
Transcription Coactivator

scholarly journals Fine-tuning of the PAX-SIX-EYA-DACH network by multiple microRNAs controls embryo myogenesis

2020 ◽  
Author(s):  
Camille Viaut ◽  
Andrea Münsterberg
Keyword(s):  
Transcription Factors ◽  
Negative Impact ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Muscle Disease ◽  
Fine Tuning ◽  
Skeletal Myogenesis ◽  
Candidate Target

AbstractMicroRNAs (miRNAs), short non-coding RNAs, which act post-transcriptionally to regulate gene expression, are of widespread significance during development and disease, including muscle disease. Advances in sequencing technology and bioinformatics led to the identification of a large number of miRNAs in vertebrates and other species, however, for many of these miRNAs specific roles have not yet been determined. LNA in situ hybridisation has revealed expression patterns of somite-enriched miRNAs, here we focus on characterising the functions of miR-128. We show that antagomir-mediated knock-down (KD) of miR-128 in developing chick somites has a negative impact on skeletal myogenesis. Computational analysis identified the transcription factor EYA4 as a candidate target consistent with the observation that miR-128 and EYA4 display similar expression profiles. Luciferase assays confirmed that miR-128 interacts with the EYA4 3’UTR. Furthermore, in vivo experiments suggest that EYA4 is regulated by miR-128, as EYA4 expression is derepressed after antagomir-mediated inhibition of miR-128. EYA4 is a member of the PAX-SIX-EYA-DACH (PSED) network of transcription factors. Therefore, we identified additional candidate miRNA binding sites in the 3’UTR of SIX1/4, EYA1/2/3 and DACH1. Using the miRanda algorithm, we found sites for miR-128, as well as for other myogenic miRNAs, miR-1a, miR-206 and miR-133a, some of these were experimentally confirmed as functional miRNA-target sites. Our results reveal that miR-128 is involved in regulating skeletal myogenesis by targeting EYA4 transcripts and moreover that the PSED network of transcription factors is co-regulated by multiple muscle-enriched microRNAs.

scholarly journals Functions and Regulatory Mechanisms of lncRNAs in Skeletal Myogenesis, Muscle Disease and Meat Production

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 1107 ◽  
Author(s):  
Shanshan Wang ◽  
Jianjun Jin ◽  
Zaiyan Xu ◽  
Bo Zuo
Keyword(s):  
Muscle Development ◽  
Chromatin Modification ◽  
Muscle Disease ◽  
Meat Production ◽  
Biological Processes ◽  
Skeletal Myogenesis ◽  
Skeletal Muscle Development ◽  
Complex Biological Process ◽  
Agricultural Animal ◽  
Microrna Sponge

Myogenesis is a complex biological process, and understanding the regulatory network of skeletal myogenesis will contribute to the treatment of human muscle related diseases and improvement of agricultural animal meat production. Long noncoding RNAs (lncRNAs) serve as regulators in gene expression networks, and participate in various biological processes. Recent studies have identified functional lncRNAs involved in skeletal muscle development and disease. These lncRNAs regulate the proliferation, differentiation, and fusion of myoblasts through multiple mechanisms, such as chromatin modification, transcription regulation, and microRNA sponge activity. In this review, we presented the latest advances regarding the functions and regulatory activities of lncRNAs involved in muscle development, muscle disease, and meat production. Moreover, challenges and future perspectives related to the identification of functional lncRNAs were also discussed.

Z-line degradation and phagocytosis of sarcomeric fragments in myonecrosis

1983 ◽  
Vol 41 ◽  
pp. 790-791
Author(s):  
Melinda L. Estes ◽  
Samuel M. Chou
Keyword(s):  
Vastus Lateralis ◽  
Inflammatory Myopathy ◽  
Muscle Disease ◽  
White Female ◽  
Inflammatory Cell Infiltrate ◽  
Limb Weakness ◽  
Muscle Diseases ◽  
History Of ◽  
The Right ◽  
Mononuclear Inflammatory Cell

Many muscle diseases show common pathological features although their etiology is different. In primary muscle diseases a characteristic finding is myofiber necrosis. The mechanism of myonecrosis is unknown. Polymyositis is a primary muscle disease characterized by acute and subacute degeneration as well as regeneration of muscle fibers coupled with an inflammatory infiltrate. We present a case of polymyositis with unusual ultrastructural features indicative of the basic pathogenetic process involved in myonecrosis.The patient is a 63-year-old white female with a one history of proximal limb weakness, weight loss and fatigue. Examination revealed mild proximal weakness and diminished deep tendon reflexes. Her creatine kinase was 1800 mU/ml (normal < 140 mU/ml) and electromyography was consistent with an inflammatory myopathy which was verified by light microscopy on biopsy muscle. Ultrastructural study of necrotizing myofiber, from the right vastus lateralis, showed: (1) degradation of the Z-lines with preservation of the adjacent Abands including M-lines and H-bands, (Fig. 1), (2) fracture of the sarcomeres at the I-bands with disappearance of the Z-lines, (Fig. 2), (3) fragmented sarcomeres without I-bands, engulfed by invading phagocytes, (Fig. 3, a & b ), and (4) mononuclear inflammatory cell infiltrate in the endomysium.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

Wurmartige Muskelbewegungen bei elektrischer Stille – Rippling Muscle Disease

2009 ◽  
Vol 36 (S 02) ◽  
Author(s):  
C Eggers ◽  
S Iglseder ◽  
S Weis ◽  
C Kubisch ◽  
BGH Schoser
Keyword(s):  
Muscle Disease
Sign in / Sign up

Export Citation Format

Share Document