Transkarbams: Transdermal Penetration-Enhancing Carbamates

Enhancement of the transdermal penetration of different active agents is an important research goal. Our aim was to establish a novelin vivoexperimental model which provides a possibility for exact measurement of the quantity of penetrated drug. The experiments were performed on SKH-1 hairless mice. A skin fold in the dorsal region was fixed with two fenestrated titanium plates. A circular wound was made on one side of the skin fold. A metal cylinder with phosphate buffer was fixed into the window of the titanium plate. The concentration of penetrated drug was measured in the buffer. The skin fold was morphologically intact and had a healthy microcirculation. The drug appeared in the acceptor buffer after 30 min, and its concentration exhibited a continuous increase. The presence of ibuprofen was also detected in the plasma. In conclusion, this model allows an exactin vivostudy of drug penetration and absorption.

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Synthesis of Esters of 6-(2,5-Dioxopyrrolidin-1-yl)-2-(2-oxoazepan-1-yl)hexanoic Acid as Potential Transdermal Penetration Enhancers

10.3390/ecsoc-14-00417 ◽

2010 ◽

Author(s):

Katerina Brychtova ◽

Jozef Csollei ◽

Josef Jampilek ◽

Lukas Placek ◽

Radka Opatrilova

Keyword(s):

Hexanoic Acid ◽

Penetration Enhancers ◽

Transdermal Penetration

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Layer-by-Layer 3D Constructs of Fibroblasts in Hydrogel for Examining Transdermal Penetration Capability of Nanoparticles

SLAS TECHNOLOGY Translating Life Sciences Innovation ◽

10.1177/2211068216655753 ◽

2016 ◽

Vol 22 (4) ◽

pp. 447-453 ◽

Cited By ~ 6

Author(s):

Xiaochun Hou ◽

Shiying Liu ◽

Min Wang ◽

Christian Wiraja ◽

Wei Huang ◽

...

Keyword(s):

Transdermal Delivery ◽

Three Dimensional ◽

Layer By Layer ◽

Surface Charges ◽

Skin Model ◽

Collagen Hydrogel ◽

Penetration Ability ◽

Charged Nanoparticles ◽

Transdermal Penetration ◽

Positively Charged

Nanoparticles are emerging transdermal delivery systems. Their size and surface properties determine their efficacy and efficiency to penetrate through the skin layers. This work utilizes three-dimensional (3D) bioprinting technology to generate a simplified artificial skin model to rapidly screen nanoparticles for their transdermal penetration ability. Specifically, this model is built through layer-by-layer alternate printing of blank collagen hydrogel and fibroblasts. Through controlling valve on-time, the spacing between printing lines could be accurately tuned, which could enable modulation of cell infiltration in the future. To confirm the effectiveness of this platform, a 3D construct with one layer of fibroblasts sandwiched between two layers of collagen hydrogel is used to screen silica nanoparticles with different surface charges for their penetration ability, with positively charged nanoparticles demonstrating deeper penetration, consistent with the observation from an existing study involving living skin tissue.

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