Intraoperative Microdialysis and Tissue-pO2 Measurement in Human Glioma

1998 ◽  
pp. 241-243 ◽  
Author(s):  
S. Baunach ◽  
Jürgen Meixensberger ◽  
M. Gerlach ◽  
J. Lan ◽  
K. Roosen
Keyword(s):  
Human Glioma ◽  
Tissue Po2 ◽  
Po2 Measurement

Brain Ischemia Detected by Tissue-PO2 Measurement and the Lactate-Oxygen Index in Head Injury

1998 ◽  
pp. 170-171 ◽  
Author(s):  
Matthias Holzschuh ◽  
C. Metz ◽  
C. Woertgen ◽  
R. D. Rothörl ◽  
A. Brawanski
Keyword(s):  
Head Injury ◽  
Brain Ischemia ◽  
Oxygen Index ◽  
Tissue Po2 ◽  
Po2 Measurement

Effect of Electrode Dimensions on Tissue pO2 Measurement in vivo

Nature ◽  
1964 ◽  
Vol 201 (4925) ◽  
pp. 1227-1228 ◽  
Author(s):  
DANA JAMIESON ◽  
H. A. S. VAN DEN BRENK
Keyword(s):  
Tissue Po2 ◽  
Po2 Measurement

Performance evaluation of recessed microcathodes: criteria for tissue PO2 measurement

1985 ◽  
Vol 58 (4) ◽  
pp. 1400-1405 ◽  
Author(s):  
D. W. Crawford ◽  
M. A. Cole
Keyword(s):  
Performance Evaluation ◽  
Diameter Ratio ◽  
Radial Diffusion ◽  
In Vivo Studies ◽  
External Diameter ◽  
O2 Consumption ◽  
Tissue Po2 ◽  
Po2 Measurement

Measurement of local tissue PO2 using recessed microcathodes has again been criticized. Therefore, we reexamined electrode performance. Sharply beveled electrodes (3 micron external diameter) were fabricated with several tip recess lengths (4–10 micron), and some recesses were filled with hydrated polymer. In vitro, 2-mm agar (3%) sheets were equilibrated with solution of known PO2 (continuously flowing). Electrode currents at 100-micron intervals through the agar and of convected superfusion solution were compared. At the longest recess lumen length-to-diameter ratio of 10, minimum response midagar (1 mm) averaged 98%. Performance improved with the use of recess polymer and increased recess length. For in vivo studies, microcathodes (ratio approximately 10) were fluid calibrated, and PO2 was measured at 10–20 micron through canine femoral artery walls. PO2 distribution fit a model for radial diffusion with medial O2 consumption. After local cyanide application to the femoral wall, PO2 fit a model for radial diffusion without tissue O2 consumption. Carefully designed microcathodes and experiments measure accurate tissue PO2.

Electrode size and tissue pO2 measurement in rats exposed to air or high pressure oxygen

1965 ◽  
Vol 20 (3) ◽  
pp. 514-518 ◽  
Author(s):  
Dana Jamieson ◽  
H. A. S. Van Den Brenk
Keyword(s):  
Tissue Damage ◽  
High Pressures ◽  
Pure Oxygen ◽  
Rat Tissues ◽  
Large Area ◽  
Pressure Oxygen ◽  
Tissue Po2 ◽  
High Pressure Oxygen ◽  
Electrode Insertion ◽  
Po2 Measurement

A comparison has been made of values of pO2 recorded in several rat tissues with 60-μ or 330-μ flexible gold electrodes. Although qualitatively both sizes of electrodes give similar results, the quantitative values of pO2differ. Such large differences as are found in some cases between electrodes varying only in physical dimensions are thought to reflect the amount of trauma caused in the tissue under investigation due to electrode insertion. Errors in pO2 estimations due to tissue damage are considered to outweigh any other errors such as those due to electrode calibration. Soft, highly vascular tissues, such as liver, kidney, and spleen, which show macroscopic bruising over quite a large area when electrodes are inserted, show the greatest difference in estimations of the pO2 value. Recordings of tissue pO2 were made while animals breathed air and when compressed to 4 or 5 atm in pure oxygen, and the pattern of response of tissue pO2 to such exposure of the animal to high pressures of oxygen is described. values of pO2; flexible electrodes; tissue damage; compressed in pure oxygen Submitted on July 24, 1964

Mutant IκBα Suppresses Hypoxia-Induced VEGF Expression Through Downregulation of HIF-1α and COX-2 in Human Glioma Cells

2005 ◽  
Vol 15 (3) ◽  
pp. 139-149 ◽  
Author(s):  
Yoshihira Kimba ◽  
Tatsuya Abe ◽  
Jian Liang Wu ◽  
Ryo Inoue ◽  
Minoru Fukiki ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Vegf Expression ◽  
Cox 2

Down Regulated Expression of Claudin-1 and Claudin-5 and Up Regulation of β-Catenin: Association with Human Glioma Progression

2014 ◽  
Vol 13 (8) ◽  
pp. 1413-1426 ◽  
Author(s):  
Hanuma Karnati ◽  
Manas Panigrahi ◽  
Noor Shaik ◽  
Nigel Greig ◽  
S. Bagadi ◽  
...  
Keyword(s):  
Human Glioma ◽  
Regulated Expression ◽  
Glioma Progression

Excess oxygen delivery during muscle contractions in spontaneously hypertensive rats

1995 ◽  
Vol 78 (1) ◽  
pp. 101-111 ◽  
Author(s):  
J. M. Lash ◽  
H. G. Bohlen
Keyword(s):  
Blood Flow ◽  
Oxygen Saturation ◽  
Oxygen Delivery ◽  
Spontaneously Hypertensive Rats ◽  
Muscle Contractions ◽  
Hypertensive Rats ◽  
Hemoglobin Oxygen Saturation ◽  
Spontaneously Hypertensive ◽  
Tissue Po2 ◽  
Wistar Kyoto

These experiments determined whether a deficit in oxygen supply relative to demand could account for the sustained decrease in tissue PO2 observed during contractions of the spinotrapezius muscle in spontaneously hypertensive rats (SHR). Relative changes in blood flow were determined from measurements of vessel diameter and red blood cell velocity. Venular hemoglobin oxygen saturation measurements were performed by using in vivo spectrophotometric techniques. The relative dilation [times control (xCT)] of arteriolar vessels during contractions was as large or greater in SHR than in normotensive rats (Wistar-Kyoto), as were the increases in blood flow (2 Hz, 3.50 +/- 0.69 vs. 3.00 +/- 1.05 xCT; 4 Hz, 10.20 +/- 3.06 vs. 9.00 +/- 1.48 xCT; 8 Hz, 16.40 +/- 3.95 vs. 10.70 +/- 2.48 xCT). Venular hemoglobin oxygen saturation was lower in the resting muscle of SHR than of Wistar-Kyoto rats (31.0 +/= 3.0 vs. 43.0 +/- 1.9%) but was higher in SHR after 4- and 8-Hz contractions (4 Hz, 52.0 +/- 4.8 vs. 43.0 +/- 3.6%; 8 Hz, 51.0 +/- 4.6 vs. 41.0 +/- 3.6%). Therefore, an excess in oxygen delivery occurs relative to oxygen use during muscle contractions in SHR. The previous and current results can be reconciled by considering the possibility that oxygen exchange is limited in SHR by a decrease in anatomic or perfused capillary density, arteriovenular shunting of blood, or decreased transit time of red blood cells through exchange vessels.

scholarly journals Differential expression and role of p21cip/waf1 and p27kip1 in TNF-α-induced inhibition of proliferation in human glioma cells

2007 ◽  
Vol 6 (1) ◽  
pp. 42 ◽  
Author(s):  
Pabbisetty Kumar ◽  
Anjali Shiras ◽  
Gowry Das ◽  
Jayashree C Jagtap ◽  
Vandna Prasad ◽  
...  
Keyword(s):  
Differential Expression ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Inhibition Of Proliferation ◽  
Tnf Α
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