Chemokines as drug targets

2007 ◽  
pp. 45-59
Author(s):  
Amanda E. I. Proudfoot ◽  
Christine A. Power ◽  
Matthias Schwarz ◽  
Timothy N. C. Wells
Keyword(s):  
Drug Targets

Discovery of Alzheimer's Molecular Pathway Reveals New Drug Targets

ASHA Leader ◽  
2013 ◽  
Vol 18 (3) ◽  
pp. 33-33
Keyword(s):  
Drug Targets ◽  
Molecular Pathway ◽  
New Drug

Discovery of Alzheimer's Molecular Pathway Reveals New Drug Targets

Novel drug targets in 2019

2020 ◽  
Vol 19 (5) ◽  
pp. 300-300 ◽  
Author(s):  
Sorin Avram ◽  
Liliana Halip ◽  
Ramona Curpan ◽  
Tudor I. Oprea
Keyword(s):  
Drug Targets ◽  
Novel Drug ◽  
Novel Drug Targets

The KidsCancerKinome - Validation of Drug Targets for High Risk Childhood Cancers

2010 ◽  
Vol 223 (01) ◽  
Author(s):  
HN Caron ◽  
EM Westerhout ◽  
M Kool ◽  
JJ Molenaar ◽  
PJ Stroeken ◽  
...  
Keyword(s):  
High Risk ◽  
Drug Targets ◽  
Childhood Cancers

Docking analyses of aryltetralin lignans on Leishmania enzyme-based drug targets

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
E Coy-Barrera ◽  
I Valdés ◽  
G Delgado
Keyword(s):  
Drug Targets

Understanding Schizophrenia: Genetic Causes and Treatment

2019 ◽  
Vol 1 (1) ◽  
pp. 6-12
Author(s):  
Fatima Javeria ◽  
Shazma Altaf ◽  
Alishah Zair ◽  
Rana Khalid Iqbal
Keyword(s):  
Copy Number ◽  
Drug Targets ◽  
Disease Risk ◽  
Mental Disease ◽  
Copy Number Variants ◽  
Aminobutyric Acid ◽  
Epigenetic Mechanisms ◽  
Gamma Aminobutyric Acid ◽  
Wide Range ◽  
Severe Mental Disease

Schizophrenia is a severe mental disease. The word schizophrenia literally means split mind. There are three major categories of symptoms which include positive, negative and cognitive symptoms. The disease is characterized by symptoms of hallucination, delusions, disorganized thinking and speech. Schizophrenia is related to many other mental and psychological problems like suicide, depression, hallucinations. Including these, it is also a problem for the patient’s family and the caregiver. There is no clear reason for the disease, but with the advances in molecular genetics; certain epigenetic mechanisms are involved in the pathophysiology of the disease. Epigenetic mechanisms that are mainly involved are the DNA methylation, copy number variants. With the advent of GWAS, a wide range of SNPs is found linked with the etiology of schizophrenia. These SNPs serve as ‘hubs’; because these all are integrating with each other in causing of schizophrenia risk. Until recently, there is no treatment available to cure the disease; but anti-psychotics can reduce the disease risk by minimizing its symptoms. Dopamine, serotonin, gamma-aminobutyric acid, are the neurotransmitters which serve as drug targets in the treatment of schizophrenia. Due to the involvement of genetic and epigenetic mechanisms, drugs available are already targeting certain genes involved in the etiology of the disease.

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