Drug Targets: Bile Acids in Motion

2014 ◽  
Author(s):  
Claudia Lupp
Keyword(s):  
Bile Acids ◽  
Drug Targets

scholarly journals Recent advances in understanding and managing cholestasis

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 705 ◽  
Author(s):  
Martin Wagner ◽  
Michael Trauner
Keyword(s):  
Bile Acids ◽  
Drug Targets ◽  
Molecular Mechanisms ◽  
Enterohepatic Circulation ◽  
Farnesoid X Receptor ◽  
Regulatory Mechanisms ◽  
Cholestatic Liver Disease ◽  
Sodium Dependent ◽  
Bile Acid Transporter ◽  
Fibroblast Growth Factor 19

Cholestatic liver diseases are hereditary or acquired disorders with impaired hepatic excretion and enterohepatic circulation of bile acids and other cholephiles. The distinct pathological mechanisms, particularly for the acquired forms of cholestasis, are not fully revealed, but advances in the understanding of the molecular mechanisms and identification of key regulatory mechanisms of the enterohepatic circulation of bile acids have unraveled common and central mechanisms, which can be pharmacologically targeted. This overview focuses on the central roles of farnesoid X receptor, fibroblast growth factor 19, and apical sodium-dependent bile acid transporter for the enterohepatic circulation of bile acids and their potential as new drug targets for the treatment of cholestatic liver disease.

Discovery of Alzheimer's Molecular Pathway Reveals New Drug Targets

ASHA Leader ◽  
2013 ◽  
Vol 18 (3) ◽  
pp. 33-33
Keyword(s):  
Drug Targets ◽  
Molecular Pathway ◽  
New Drug

Discovery of Alzheimer's Molecular Pathway Reveals New Drug Targets

Novel drug targets in 2019

2020 ◽  
Vol 19 (5) ◽  
pp. 300-300 ◽  
Author(s):  
Sorin Avram ◽  
Liliana Halip ◽  
Ramona Curpan ◽  
Tudor I. Oprea
Keyword(s):  
Drug Targets ◽  
Novel Drug ◽  
Novel Drug Targets

The KidsCancerKinome - Validation of Drug Targets for High Risk Childhood Cancers

2010 ◽  
Vol 223 (01) ◽  
Author(s):  
HN Caron ◽  
EM Westerhout ◽  
M Kool ◽  
JJ Molenaar ◽  
PJ Stroeken ◽  
...  
Keyword(s):  
High Risk ◽  
Drug Targets ◽  
Childhood Cancers

Docking analyses of aryltetralin lignans on Leishmania enzyme-based drug targets

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
E Coy-Barrera ◽  
I Valdés ◽  
G Delgado
Keyword(s):  
Drug Targets

Gut permeability and serum bile acids in metabolic syndrome

2013 ◽  
Vol 51 (05) ◽  
Author(s):  
B Leber ◽  
N Tripolt ◽  
A Horvath ◽  
S Lemesch ◽  
T Stojakovic ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bile Acids ◽  
Gut Permeability ◽  
Serum Bile Acids

Plasma bile acids show a positive correlation with body mass index which may play a role in eating behavior

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
P Prinz ◽  
T Hofmann ◽  
A Ahnis ◽  
U Elbelt ◽  
M Goebel-Stengel ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Bile Acids ◽  
Body Mass ◽  
Eating Behavior ◽  
Positive Correlation
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