A Molecular Basis for Multidrug-Resistance and Reversal of the Resistance

1991 ◽  
pp. 63-72
Author(s):  
Shin-Ichi Akiyama ◽  
Akihiko Yoshimura ◽  
Misako Ichikawa ◽  
Tomoyuki Sumizawa ◽  
Tatsuhiko Furukawa
Keyword(s):  
Multidrug Resistance ◽  
Molecular Basis

scholarly journals Development of modulators of multidrug resistance: A pharmacoinformatic approach

2004 ◽  
Vol 76 (5) ◽  
pp. 997-1005 ◽  
Author(s):  
G. F. Ecker ◽  
Peter Chiba
Keyword(s):  
Neural Networks ◽  
Multidrug Resistance ◽  
Molecular Basis ◽  
Tumor Therapy ◽  
3D Qsar ◽  
Drug Efflux ◽  
Qsar Studies ◽  
P Glycoprotein ◽  
Drug Efflux Pumps ◽  
2D And 3D

Inhibition of drug efflux pumps such as P-glycoprotein represents a versatile approach for overcoming multidrug resistance in tumor therapy. Although numerous compounds have been identified as being able to inhibit P-glycoprotein, only little is known on the molecular basis of the drug–protein interaction. This article gives an overview of the different pharmacoinformatic approaches we used to develop new propafenone-type modulators of P-glycoprotein. These include 2D-and 3D-QSAR studies, artificial neural networks, and photoaffinity labeling studies.

Molecular basis of polyspecificity of the Small Multidrug Resistance Efflux Pump AbeS from Acinetobacter baumannii

2016 ◽  
Vol 428 (3) ◽  
pp. 644-657 ◽  
Author(s):  
Iryna Lytvynenko ◽  
Shlomo Brill ◽  
Christine Oswald ◽  
Klaas M. Pos
Keyword(s):  
Multidrug Resistance ◽  
Acinetobacter Baumannii ◽  
Molecular Basis ◽  
Efflux Pump ◽  
Small Multidrug Resistance

scholarly journals Fungicide-Driven Evolution and Molecular Basis of Multidrug Resistance in Field Populations of the Grey Mould Fungus Botrytis cinerea

2009 ◽  
Vol 5 (12) ◽  
pp. e1000696 ◽  
Author(s):  
Matthias Kretschmer ◽  
Michaela Leroch ◽  
Andreas Mosbach ◽  
Anne-Sophie Walker ◽  
Sabine Fillinger ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Botrytis Cinerea ◽  
Molecular Basis ◽  
Grey Mould ◽  
Mould Fungus

scholarly journals The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research

FEBS Letters ◽  
2005 ◽  
Vol 580 (4) ◽  
pp. 998-1009 ◽  
Author(s):  
Michael M. Gottesman ◽  
Victor Ling
Keyword(s):  
Multidrug Resistance ◽  
Molecular Basis ◽  
Early Years ◽  
P Glycoprotein

The Molecular Basis of the Action of Disulfiram as a Modulator of the Multidrug Resistance-Linked ATP Binding Cassette Transporters MDR1 (ABCB1) and MRP1 (ABCC1)

2004 ◽  
Vol 65 (3) ◽  
pp. 675-684 ◽  
Author(s):  
Zuben E. Sauna ◽  
Xiang-Hong Peng ◽  
Krishnamachary Nandigama ◽  
Samrawit Tekle ◽  
Suresh V. Ambudkar
Keyword(s):  
Multidrug Resistance ◽  
Molecular Basis ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

scholarly journals Antibiotic-resistant staphylococci from the wastewater treatment plant and grey-water samples in Obafemi Awolowo University, Ile-Ife, Nigeria

2020 ◽  
Vol 18 (6) ◽  
pp. 890-898
Author(s):  
Tomiwa Olumide Adesoji ◽  
Beverly Egyir ◽  
Adebayo Osagie Shittu
Keyword(s):  
Wastewater Treatment ◽  
Multidrug Resistance ◽  
Wastewater Treatment Plant ◽  
Water Samples ◽  
Molecular Basis ◽  
Treatment Plant ◽  
Grey Water ◽  
Antibiotic Resistant ◽  
Microbiological Techniques ◽  
Human Animal

Abstract This study examined the occurrence and molecular basis for antibiotic-resistant staphylococci from the wastewater treatment plant and grey-water samples in Obafemi Awolowo University, Nigeria. Standard microbiological techniques and molecular methods were utilized. The species identified (MALDI score >1.7) comprised S. saprophyticus (19), S. cohnii (8), S. sciuri (7), S. aureus (4), S. epidermidis (3), S. warneri (2), S. equorum (1), S. haemolyticus (1), S. nepalensis (1), S. condimenti (1), and S. pasteuri (1). Resistance to trimethoprim, tetracycline and cefoxitin were observed in 78.3% (47/60), 36.7% (22/60) and 25% (15/60) of the isolates, respectively. The rate of multidrug resistance was 53.3% (32/60) and observed in eight species from different sampling sites. Seven (S. sciuri; n = 5; S. aureus; n = 1; S. warneri; n = 1) of the 20 selected (representing the various staphylococcal species and antibiotypes) isolates were mecA-positive. Furthermore, the tetK gene was detected in nine isolates, six with dfrA, and four were positive for the dfrG gene. One S. aureus was mecA, tetK and dfrG gene positive. The study provides insights on antibiotic-resistant staphylococci from a non-clinical setting and highlights the need for active surveillance to understand the burden of antimicrobial resistance in Nigeria. This is key to improve synergy across the human, animal and environmental health sectors in Nigeria.

Sign in / Sign up

Export Citation Format

Share Document