PET–CT Imaging of Lung Cancer: The Current Status and Future Potentials

2014 ◽  
pp. 91-112
Author(s):  
Sunita Sonavane ◽  
Sandip Basu
Keyword(s):  
Lung Cancer ◽  
Ct Imaging ◽  
Current Status ◽  
Pet Ct

Automating Lung Cancer Identification in PET/CT Imaging

2018 ◽  
Author(s):  
E. D'Arnese ◽  
E. Del Sozzo ◽  
A. Chiti ◽  
T. Berger-Wolf ◽  
M. D. Santambrogio
Keyword(s):  
Lung Cancer ◽  
Ct Imaging ◽  
Pet Ct

scholarly journals Dynamic PET/CT Imaging of 68Ga-FAPI-04 in Chinese Subjects

2021 ◽  
Vol 11 ◽  
Author(s):  
Shuailiang Wang ◽  
Xin Zhou ◽  
Xiaoxia Xu ◽  
Jin Ding ◽  
Teli Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Body Mass ◽  
Fdg Pet ◽  
Radiation Dosimetry ◽  
Ct Imaging ◽  
Lung Cancer Patients ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Chinese Subjects

This study aims to further explore dynamic 68Ga-FAPI-04 PET/CT imaging of healthy Chinese subjects and lung cancer patients. Moreover, the variability of 68Ga-FAPI-04 uptake in normal organs was measured to provide a basis for analyzing its biological distribution, interpreting auxiliary images, determining the reliability of image quantification, and monitoring treatment. Six patients (3 subjects without tumors and 3 lung cancer patients) separately underwent 68Ga-FAPI-04 and 2-[18F]FDG PET/CT imaging within 1 week. The biodistribution and internal radiation dosimetry were reported and compared with data previously obtained from Caucasian patients. Moreover, the mean SUV (standardized uptake value) was normalized to body mass or to lean body mass (SUL), and the coefficients of variation (CVs) were calculated and compared for each volume of interest. The average whole-body effective dose was calculated to be 1.27E-02 mSv/MBq, which was comparable with previously reported results of 68Ga-FAPI-04 probes. Furthermore, the SUVmean was slightly higher than the SULmean in most organs; however, the CV of the SULmean for most organs was higher than that of the SUVmean at later time points. In the liver, the CV of the SUVmean was lower (12.7%) than that of the SULmean and was similar to the CV for corresponding 2-[18F]FDG PET/CT value (11.8%). In addition, 68Ga-FAPI-04 PET/CT showed good efficacy for diagnosing lung cancer patients in this study. A comparison of the radiation dosimetry obtained before from a Caucasian population demonstrated no clinically significant differences between these two populations after 68Ga-FAPI-04 injection. The variability in most organs was slightly lower for SUVmean than for SULmean, suggesting that SUVmean may be the preferable parameter for quantifying images obtained with 68Ga-FAPI-04. In addition, 68Ga-FAPI-04 PET/CT imaging is expected to be a promising tool for diagnosing lung cancer.

scholarly journals PET/CT imaging in lung cancer: indications and findings

2015 ◽  
Vol 41 (3) ◽  
pp. 264-274 ◽  
Author(s):  
Bruno Hochhegger ◽  
Giordano Rafael Tronco Alves ◽  
Klaus Loureiro Irion ◽  
Carlos Cezar Fritscher ◽  
Leandro Genehr Fritscher ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Nodules ◽  
Cancer Staging ◽  
Ct Imaging ◽  
Inappropriate Treatment ◽  
Pet Ct ◽  
Disease Staging ◽  
Anatomical Information ◽  
Work Up

The use of PET/CT imaging in the work-up and management of patients with lung cancer has greatly increased in recent decades. The ability to combine functional and anatomical information has equipped PET/CT to look into various aspects of lung cancer, allowing more precise disease staging and providing useful data during the characterization of indeterminate pulmonary nodules. In addition, the accuracy of PET/CT has been shown to be greater than is that of conventional modalities in some scenarios, making PET/CT a valuable noninvasive method for the investigation of lung cancer. However, the interpretation of PET/CT findings presents numerous pitfalls and potential confounders. Therefore, it is imperative for pulmonologists and radiologists to familiarize themselves with the most relevant indications for and limitations of PET/CT, seeking to protect their patients from unnecessary radiation exposure and inappropriate treatment. This review article aimed to summarize the basic principles, indications, cancer staging considerations, and future applications related to the use of PET/CT in lung cancer.

PET/CT imaging in response evaluation of patients with small cell lung cancer

Lung Cancer ◽  
2006 ◽  
Vol 54 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Barbara M. Fischer ◽  
Jann Mortensen ◽  
Seppo W. Langer ◽  
Annika Loft ◽  
Anne K. Berthelsen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Ct Imaging ◽  
Small Cell ◽  
Response Evaluation ◽  
Small Cell Lung ◽  
Pet Ct

Etiology of Solitary Extrapulmonary Positron Emission Tomography and Computed Tomography Findings in Patients With Lung Cancer

2005 ◽  
Vol 23 (28) ◽  
pp. 6846-6853 ◽  
Author(s):  
Didier Lardinois ◽  
Walter Weder ◽  
Marina Roudas ◽  
Gustav K. von Schulthess ◽  
Michaela Tutic ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Positron Emission Tomography ◽  
Ct Imaging ◽  
Emission Tomography ◽  
Whole Body ◽  
Benign Tumors ◽  
Positron Emission ◽  
Pet Ct ◽  
The Impact

Purpose The aim of this prospective study was to assess the incidence and the nature of solitary extrapulmonary [18F] fluorodeoxyglucose (FDG) accumulations in patients with non–small-cell lung cancer (NSCLC) staged with integrated positron emission tomography and computed tomography (PET/CT) and to evaluate the impact on management. Patients and Methods A total of 350 patients with NSCLC underwent whole-body PET/CT imaging. All solitary extrapulmonary FDG accumulations were evaluated by histopathology, further imaging, or clinical follow-up. Results PET/CT imaging revealed extrapulmonary lesions in 110 patients. In 72 patients (21%), solitary lesions were present. A diagnosis was obtained in 69 of these patients, including 37 (54%) with solitary metastases and 32 (46%) with lesions unrelated to the lung primary. Histopathologic examinations of these 32 lesions revealed a second clinically unsuspected malignancy or a recurrence of a previous diagnosed carcinoma in six patients (19%) and a benign tumor or inflammatory lesion in 26 patients (81%). The six malignancies consisted of carcinoma of the breast in two patients, and carcinoma of the orbit, esophagus, prostate, and non-Hodgkin's lymphoma in one patient each. Benign tumors and inflammatory lesions included eight colon adenomas, four Warthin's tumors, one granuloma of the lower jaw, one adenoma of the thyroid gland, one compensatory muscle activity due to vocal chord palsy, two occurrences of arthritis, three occurrences of reflux esophagitis, two occurrences of pancreatitis, two occurrences of diverticulitis, one hemorrhoidal inflammation, and one rib fracture. Conclusion Solitary extrapulmonary FDG accumulations in patients with newly diagnosed lung cancer should be analyzed critically for correct staging and optimal therapy, given that up to half of the lesions may represent unrelated malignancies or benign disease.

scholarly journals 18F-RGD PET/CT imaging reveals characteristics of angiogenesis in non-small cell lung cancer

2020 ◽  
Vol 9 (4) ◽  
pp. 1324-1332 ◽  
Author(s):  
Li Li ◽  
Wei Zhao ◽  
Xiaorong Sun ◽  
Ning Liu ◽  
Yue Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Ct Imaging ◽  
Small Cell ◽  
Small Cell Lung ◽  
Pet Ct

scholarly journals A Rare Case of Penile Metastases as a Harbinger of Primary Pulmonary Adenosquamous Carcinoma

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Partha Hota ◽  
Tejas N. Patel ◽  
Xiaofeng Zhao ◽  
Carrie Schneider ◽  
Omar Agosto
Keyword(s):  
Lung Cancer ◽  
Small Bowel ◽  
Mr Imaging ◽  
Rare Case ◽  
Adenosquamous Carcinoma ◽  
Ct Imaging ◽  
Subscapularis Muscle ◽  
Pet Ct ◽  
The Right ◽  
Penile Metastases

Although lung cancer has a high propensity for distant metastatic disease, penile metastases from primary lung neoplasms are considered particularly rare. A 71-year-old male presented to our hospital with a rapidly enlarging hard palpable penile mass. MR imaging demonstrated two penile masses centered in the left and right corpus cavernosa. Subsequent CT imaging revealed a spiculated pulmonary mass in the right upper lobe with PET/CT, MRI, and surgical exploration, demonstrating evidence of metastases to the left adrenal gland, right subscapularis muscle, brain, and small bowel. Tissue sampling of lesions in the small bowel, right subscapularis muscle, and penis demonstrated histopathology consistent with an adenosquamous carcinoma which in combination with the appearance of the right upper lobe mass on PET/CT imaging suggested the patient’s lung cancer as the primary lesion. Prior to our case, pulmonary adenosquamous carcinoma metastasizing to the penis has only been reported once in the literature. Herein, we report a rare case of penile metastases as the presenting sign of metastatic pulmonary adenosquamous carcinoma characterized with PET/CT and MR imaging.

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