Primary Ocular HSV Infections in Adults

Herpes simplex virus (HSV) infections are among the most common viral infections and usually last for a lifetime. The virus can potentially be controlled with vaccines since humans are the only known host. However, despite the development and trial of many vaccines, this has not yet been possible. This is normally attributed to the high latency potential of the virus. Numerous immune cells, particularly the natural killer cells and interferon gamma and pathways that are used by the body to fight HSV infections have been identified. On the other hand, the virus has developed different mechanisms, including using different microRNAs to inhibit apoptosis and autophagy to avoid clearance and aid latency induction. Both traditional and new methods of vaccine development, including the use of live attenuated vaccines, replication incompetent vaccines, subunit vaccines and recombinant DNA vaccines are now being employed to develop an effective vaccine against the virus. We conclude that this review has contributed to a better understanding of the interplay between the immune system and the virus, which is necessary for the development of an effective vaccine against HSV.

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Brincidofovir (CMX-001) for refractory and resistant CMV and HSV infections in immunocompromised cancer patients: A single-center experience

Antiviral Research ◽

10.1016/j.antiviral.2016.08.024 ◽

2016 ◽

Vol 134 ◽

pp. 58-62 ◽

Cited By ~ 24

Author(s):

Danielle El-Haddad ◽

Firas El Chaer ◽

Jackapat Vanichanan ◽

Dimpy P. Shah ◽

Ella J. Ariza-Heredia ◽

...

Keyword(s):

Cancer Patients ◽

Single Center ◽

Single Center Experience ◽

Hsv Infections

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Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

Viruses ◽

10.3390/v10090473 ◽

2018 ◽

Vol 10 (9) ◽

pp. 473 ◽

Cited By ~ 20

Author(s):

Giuseppe Annunziata ◽

Maria Maisto ◽

Connie Schisano ◽

Roberto Ciampaglia ◽

Viviana Narciso ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Bioactive Compounds ◽

Antiviral Agents ◽

Mechanisms Of Action ◽

The Body ◽

Human Virus ◽

Simplex Virus ◽

Different Parts ◽

Hsv Infections

The herpes simplex virus (HSV) is a common human virus affecting many people worldwide. HSV infections manifest with lesions that occur in different parts of the body, including oral, ocular, nasal, and genital skin and mucosa. In rare cases, HSV infections can be serious and lethal. Several anti-HSV drugs have been developed, but the existence of mutant viruses resistant to these drugs led to the individuation of novel antiviral agents. Plant-derived bioactive compounds, and more specifically polyphenols, have been demonstrated to exert marked anti-HSV activity and, among these, resveratrol (RSV) would be considered a good candidate. The purpose of this manuscript is to review the available literature elucidating the efficacy of RSV against HSV and the main demonstrated mechanisms of action.

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