Outcomes of Diabetic Microvascular Complications After Bariatric Surgery

2017 ◽  
pp. 137-144
Author(s):  
Helen M. Heneghan ◽  
Carel W. le Roux
Keyword(s):  
Bariatric Surgery ◽  
Microvascular Complications ◽  
Complications After Bariatric Surgery ◽  
Diabetic Microvascular Complications

Obesity, Metabolic Syndrome and the Risk of Microvascular Complications in Patients with Diabetes mellitus

2019 ◽  
Vol 25 (18) ◽  
pp. 2051-2059 ◽  
Author(s):  
Niki Katsiki ◽  
Panagiotis Anagnostis ◽  
Kalliopi Kotsa ◽  
Dimitrios G. Goulis ◽  
Dimitri P. Mikhailidis
Keyword(s):  
Diabetes Mellitus ◽  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Kidney Disease ◽  
Microvascular Complications ◽  
Atherogenic Dyslipidemia ◽  
Cardiac Autonomic Neuropathy ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Diabetic Microvascular Complications

Background:: Obesity frequently co-exists with type 2 diabetes mellitus (T2DM), leading to the socalled “diabesity epidemic”. The metabolic syndrome (MetS), a cluster of central obesity, hypertension, dysglycemia, insulin resistance and/or atherogenic dyslipidemia, as well as non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of MetS, has been associated with increased cardiovascular disease (CVD), T2DM and chronic kidney disease (CKD) incidence. However, the association between obesity, MetS (including NAFLD) and diabetic microvascular complications is less evident. Methods:: The present narrative review discusses the associations of obesity, MetS and NAFLD with diabetic kidney disease (DKD), diabetic retinopathy (DR) and diabetic peripheral neuropathy (DPN) as well as cardiac autonomic neuropathy (CAN). The available data on the effects of lifestyle measures and bariatric surgery on these diabetic complications are also briefly discussed. Results: : Overall, both obesity and MetS have been related to DKD, DR and DPN, although conflicting results exist. Links between NAFLD and diabetic microvascular complications have also been reported but data are still limited. Lifestyle intervention and bariatric surgery may prevent the development and/or progression of these microvascular complications but more evidence is needed. Conclusion:: Clinicians should be aware of the frequent co-existence of MetS and/or NAFLD in T2DM patients to prevent or treat these metabolic disorders, thus potentially minimizing the risk for both CVD and diabetic microvascular complications.

N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications

2003 ◽  
Vol 20 (5) ◽  
pp. 419-420 ◽  
Author(s):  
H. Pang ◽  
Y. Koda ◽  
S.-I. Yamagishi ◽  
S. Amano ◽  
Y. Inagaki ◽  
...  
Keyword(s):  
Microvascular Complications ◽  
Diabetic Microvascular Complications

Effects of obesity and bariatric surgery on HDL functionality and microvascular complications of obesity

2016 ◽  
Vol 252 ◽  
pp. e221-e222 ◽  
Author(s):  
Y. Liu ◽  
T. Siahmansur ◽  
J.D. Schofield ◽  
S. Hama ◽  
R. Yadav ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Microvascular Complications ◽  
Hdl Functionality

scholarly journals Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes

Diabetologia ◽  
2015 ◽  
Vol 59 (3) ◽  
pp. 472-480 ◽  
Author(s):  
Valma Harjutsalo ◽  
◽  
Christine Maric-Bilkan ◽  
Carol Forsblom ◽  
Per-Henrik Groop
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications ◽  
Age At Menarche ◽  
Diabetic Microvascular Complications

Association Between Serum Fibrinogen Levels and Diabetic Microvascular Complications in Type 2 Diabetes Mellitus

2007 ◽  
Vol 17 (6) ◽  
pp. 306-308 ◽  
Author(s):  
Huseyin Demirci ◽  
Husamettin Erdamar ◽  
Ayhan Karakoc ◽  
Fusun Balos Toruner ◽  
Mehmet Akif Ozturk ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Diabetic Microvascular Complications

Mean Platelet Volume and Platelet Distribution Width Correlate with Microvascular Complications in Egyptian People with Type 2 Diabetes Mellitus

2021 ◽  
Vol 17 ◽  
Author(s):  
Mohammed I. Abd El-Ghany ◽  
Nahed Abdallah ◽  
Waleed Eldars
Keyword(s):  
Type 2 Diabetes ◽  
Mean Platelet Volume ◽  
Microvascular Complications ◽  
Fasting Blood Glucose ◽  
Vascular Complications ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Diabetic Microvascular Complications

Background: Type 2 diabetes is a part of metabolic syndrome associated with a higher risk of vascular complications. Diabetes is characterized by changes in platelet morphology, function, and platelet hyperactivity so, it's considered a prothrombotic condition. Morbidity and mortality in people with type 2 diabetes-related to micro and macrovascular complications. Novel biomarkers are needed to identify and treat people at higher risk. Objective: The main objective of this controlled cross-sectional study was to evaluate Platelet volume indices (PVI) in subjects with type 2 diabetes with and without complications in comparison to subjects without diabetes. Methods: Hundred and thirty-five subjects aged from 35 to 60 years were subdivided into 3 groups. Group A includes 55 subjects with type 2 diabetes with complications. Group B includes 45 subjects with type 2 diabetes without complications. Group C includes 35 normal healthy subjects. Detailed clinical history was taken. Also, PVI, fasting blood glucose (FBG), hemoglobin A1c, and creatinine were obtained. Results: Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), and Platelet large cell ratio (P-LCR) were significantly higher among subjects with retinopathy, nephropathy, and neuropathy than other subjects with diabetes who didn't develop complications (P<0.001). At cutoff value > 11.9 fL, MPV have diagnostic sensitivity 80% and specificity 97.8%. Whereas PDW >16.9fL has a sensitivity of 74.5% and specificity of 100% for diabetic microvascular complications (retinopathy, nephropathy, and neuropathy). Conclusion: MPV and PDW may be considered as possible biomarkers for the early detection of diabetic microvascular complications.

scholarly journals To study levels of serum fibrinogen in type 2 diabetes mellitus and its association with diabetic microvascular complications

2017 ◽  
Vol 4 (1) ◽  
pp. 10
Author(s):  
Gurinder Mohan ◽  
Ranjeet Kaur ◽  
Aakash Aggarwal ◽  
Parminder Singh
Keyword(s):  
Diabetes Mellitus ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
High Serum ◽  
Diabetic Patients ◽  
Coagulation Disorder ◽  
Urine Albumin ◽  
Group A ◽  
Diabetic Microvascular Complications ◽  
Group B

Background: Diabetes mellitus is a hypercoagulable state associated with atherosclerosis leading to development of vascular complications, including microvascular complications.Methods: In our study a total of 60 diabetic patients with duration of diabetes more than 5 years, attending the OPD/ indoor of SGRDIMSR, Amritsar, Punjaqqb, India were included. They were divided in two groups, group A of 30 patients including diabetics with any of the three microvascular complications (diabetic nephropathy, diabetic retinopathy and diabetic neuropathy) and group B of 30 patients including diabetics without any microvascular complication. Group C comprised of 30 age and sex matched non-diabetic subjects who served as controls. Subjects with liver cirrhosis, malignancy or coagulation disorder were excluded. After taking the consent, detailed history taking and detailed physical examination and relevant investigations were done. The serum fibrinogen (hemostasis marker), HBA1C and UACR (urine albumin creatinine ratio) along with routine investigations were measured.Results: It was observed that serum fibrinogen levels were significantly higher in diabetic patients (266.16±54.73 mg/dl) as compared to non-diabetic controls (174.66±18.32 mg/dl); p <0.001.Further, serum fibrinogen levels were found to be significantly higher in diabetic patients with microvascular complications (293.43±51.09 mg/dl) as compared to those without microvascular complications (238.90±44.12); p<0.001.Conclusions: Significantly high serum fibrinogen level was found in diabetic patients as compared to controls and was in positive correlation with development of microvascular complications.

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