EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma

2017 ◽  
pp. 75-90 ◽  
Author(s):  
Jun Zhang ◽  
Lin Jia ◽  
Chi Man Tsang ◽  
Sai Wah Tsao
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Glucose Metabolism ◽  
Ebv Infection

scholarly journals The initial study of EBNA-2 polymorphisms in nasopharyngeal carcinoma in Vietnam

2020 ◽  
Vol 8 (1) ◽  
pp. 60-67
Author(s):  
Ngo Dong Kha ◽  
Huynh Thi Mong Tuyen ◽  
Lam Hong Ngoc ◽  
Thieu Hong Hue ◽  
Le Quang Anh Tuan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Initial Data ◽  
Epstein Barr Virus ◽  
Initial Study ◽  
Nucleotide Sequencing ◽  
Potential Contribution ◽  
Barr Virus ◽  
Ebv Infection ◽  
Vietnamese Population ◽  
Epstein Barr

Epstein-Barr virus (EBV) infection is the main cause of Nasopharyngeal Carcinoma (NPC). EBNA-2, one of the most important genes participating in the formation of NPC, also helps EBV evade an attack on the immune system. EBNA-2 has 4 variants including E2-A, E2-B, E2-C and E-2D, of which E2-A and E2-C are the characterized variants for NPC. This study aimed to evaluate the variations of EBNA-2 in NPC biopsy samples of Vietnamese patients. This initial study used 10 biopsy samples, which were positively confirmed to NPC, collected from Cho Ray Hospital. Nested PCR – nucleotide sequencing was applied to analyze the variants of EBNA-2. The results showed that 8 out of 10 samples, accounting for 80%, were positive to EBNA-2. Additionally, only two variants, E-2A and E-2C were detected in our study, in which, E2-A subtype was identified as the predominant subtype. These findings would provide initial data about potential contribution of EBNA-2 polymorphisms to etiology of NPC in Vietnamese population.

scholarly journals CORRELATION BETWEEN NUCLEUS FACTOR KAPPA B AND MICROVESSEL DENSITY IN NASOPHARYNGEAL CARCINOMA

2020 ◽  
Vol 2 (02) ◽  
pp. 40-43
Author(s):  
Farrel ◽  
Izry Naomi Tobing ◽  
Fahat ◽  
Rizalina A Asnir ◽  
Adlin Adnan
Keyword(s):  
Head And Neck Cancer ◽  
Nasopharyngeal Carcinoma ◽  
Microvessel Density ◽  
Nuclear Factor Kappa B ◽  
Nuclear Proliferation ◽  
Nonparametric Test ◽  
Tumor Promoter ◽  
Nuclear Factor ◽  
Research Needs ◽  
Ebv Infection

Abstract Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer, mostly associated with EBV infection. Nuclear factor kappa B (NF-κB) is transcription factors that act as a tumor promoter, especially in inflammation-associated cancer. It also attracts angiogenesis. Microvessel Density (MVD) is widely used as an index for tumor angiogenesis. There have been no studies found about the correlation of NF-κB and MVD expression in NPC. Objective: The aim of this study is to investigate the correlation of NF-κB and MVD expression that may affect targeted therapies in NPC patients Methods: A total of 30 paraffin blocks of NPC patients biopsies were assessed immunohistochemically for NF-κB expression and MVD. Data were analyzed using the Spearman's nonparametric test to assess the correlation between NF-κB expression and MVD. Results: Positive NF-κB expression was found in 22 (73.33%) patients and negative in 8 (26.67%) patients. High MVD expression in 17 (56.67%) patients and low MVD expression in 13 (43.33%) patients. There was no significant correlation found between NF-κB and MVD. Conclusion: This study has not confirmed any correlation between NF-κB and MVD. Further research needs to be done to get a better assessment on nuclear proliferation rates and tumor-related angiogenesis in NPC.

scholarly journals Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma Carcinogenesis

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2441 ◽  
Author(s):  
Timmy Richardo ◽  
Pongphol Prattapong ◽  
Chawalit Ngernsombat ◽  
Nurulfitri Wisetyaningsih ◽  
Hisashi Iizasa ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Southeast Asia ◽  
Signaling Pathways ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Ebv Infection ◽  
Non Coding Rnas ◽  
Epstein Barr ◽  
Exact Relationship

Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which is Epstein-Barr virus (EBV) infection. Although evidence demonstrates that EBV infection plays a key role in NPC carcinogenesis, the exact relationship between EBV and dysregulation of signaling pathways in NPC needs to be clarified. This review focuses on the interplay between EBV and NPC cells and the corresponding signaling pathways, which are modulated by EBV oncoproteins and non-coding RNAs. These altered signaling pathways could be critical for the initiation and progression of NPC.

scholarly journals Link of Nasopharyngeal Carcinoma and Epstein-Barr Virus

2018 ◽  
Vol 7 (2) ◽  
pp. 51-55
Author(s):  
Sugiyanto Sugiyanto ◽  
Lina Aryati ◽  
Fajar Adi Kusumo ◽  
Mardiah Suci Hardianti
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Carcinoma Cells ◽  
Lymphoid Cells ◽  
Epithelial Tissue ◽  
Barr Virus ◽  
Ebv Infection ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Basic Level

Nasopharyngeal Carcinoma (NPC) is a cancer that occurs in nasopharynx which is associated with Epstein-Barr Virus (EBV). Mutation agents in nasopharyngeal neoplasms occur because of EBV infection. Transformation of B-cells due to EBV causes hormone imbalance in lymphoid cells or nasopharyngeal epithelial tissue. Rates of EBV infection have been shown to be prognostic to NPC. The basic level of EBV DNA can be used for stratification prognosis, with higher titers showing greater disease severity and worse outcomes. With mathematical models, there is a correlation between the increase in Epstein-Barr Virus and the increase in Invasive Carcinoma Cells or increase in Nasopharyngeal Carcinoma Cells.

scholarly journals Reconstitution of Nasopharyngeal Carcinoma–Type EBV Infection Induces Tumorigenicity

2008 ◽  
Vol 68 (4) ◽  
pp. 1030-1036 ◽  
Author(s):  
Eri Seto ◽  
Tadamasa Ooka ◽  
Jaap Middeldorp ◽  
Kenzo Takada
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Ebv Infection

scholarly journals Role of Epstein-Barr virus in the development of nasopharyngeal carcinoma

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 171-176 ◽  
Author(s):  
Hui Zhang ◽  
Jing Wang ◽  
Dan Yu ◽  
Yan Liu ◽  
Kai Xue ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Ebv Infection ◽  
Micro Rnas ◽  
Total Cancer ◽  
Epstein Barr

AbstractSouthern China experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. Risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which Epstein-Barr virus (EBV) infection is the mostly investigated. The study into mechanism of EBV in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. The pathophysiology in making of EBV into a cancerogen includes proteins as latent membrane protein 1 (LMPs) and nucleic acids as micro-RNAs. In this paper, we reviewed till date studies focusing on relationship between EBV and nasopharyngeal carcinoma.

scholarly journals Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells

2015 ◽  
Vol 89 (15) ◽  
pp. 7612-7624 ◽  
Author(s):  
Laura R. Wasil ◽  
Leizhen Wei ◽  
Christopher Chang ◽  
Li Lan ◽  
Kathy H. Y. Shair
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Dna Repair ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Combined Effects ◽  
Barr Virus ◽  
Ebv Infection ◽  
Dna Damage Signaling ◽  
Epstein Barr

ABSTRACTNasopharyngeal carcinoma (NPC) is closely associated with latent Epstein-Barr virus (EBV) infection. Although EBV infection of preneoplastic epithelial cells is not immortalizing, EBV can modulate oncogenic and cell death mechanisms. The viral latent membrane proteins 1 (LMP1) and LMP2A are consistently expressed in NPC and can cooperate in bitransgenic mice expressed from the keratin-14 promoter to enhance carcinoma development in an epithelial chemical carcinogenesis model. In this study, LMP1 and LMP2A were coexpressed in the EBV-negative NPC cell line HK1 and examined for combined effects in response to genotoxic treatments. In response to DNA damage activation, LMP1 and LMP2A coexpression reduced γH2AX (S139) phosphorylation and caspase cleavage induced by a lower dose (5 μM) of the topoisomerase II inhibitor etoposide. Regulation of γH2AX occurred before the onset of caspase activation without modulation of other DNA damage signaling mediators, including ATM, Chk1, or Chk2, and additionally was suppressed by inducers of DNA single-strand breaks (SSBs) and replication stress. Despite reduced DNA damage repair signaling, LMP1-2A coexpressing cells recovered from cytotoxic doses of etoposide; however, LMP1 expression was sufficient for this effect. LMP1 and LMP2A coexpression did not enhance cell growth, with a moderate increase of cell motility to fibronectin. This study supports that LMP1 and LMP2A jointly regulate DNA repair signaling and cell death activation with no further enhancement in the growth properties of neoplastic cells.IMPORTANCENPC is characterized by clonal EBV infection and accounts for >78,000 annual cancer cases with increased incidence in regions where EBV is endemic, such as southeast Asia. The latent proteins LMP1 and LMP2A coexpressed in NPC can individually enhance growth or survival properties in epithelial cells, but their combined effects and potential regulation of DNA repair and checkpoint mechanisms are relatively undetermined. In this study, LMP1-2A coexpression suppressed activation of the DNA damage response (DDR) protein γH2AX induced by selective genotoxins that promote DNA replication stress or SSBs. Expression of LMP1 was sufficient to recover cells, resulting in outgrowth of LMP1 and LMP1-2A-coexpressing cells and indicating distinct LMP1-dependent effects in the restoration of replicative potential. These findings demonstrate novel properties for LMP1 and LMP2A in the cooperative modulation of DDR and apoptotic signaling pathways, further implicating both proteins in the progression of NPC and epithelial malignancies.

scholarly journals The effect of functionalMAPKAPK2copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection

2013 ◽  
Vol 35 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Lei Yang ◽  
Bin Liu ◽  
Fuman Qiu ◽  
Binfang Huang ◽  
Yinyan Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Ebv Infection ◽  
Number Variation ◽  
Carcinoma Risk
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