The Development of Extracellular Vesicle-Integrated Biomaterials for Bone Regeneration

Faculty Opinions recommendation of Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727471342.793531985 ◽

2017 ◽

Author(s):

Hermann Agis ◽

Michael Edelmayer

Keyword(s):

Bone Regeneration ◽

Bone Matrix ◽

Extracellular Vesicle ◽

Decalcified Bone Matrix

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Extracellular vesicle and mesenchymal stem cells in bone regeneration: recent progress and perspectives

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.36518 ◽

2018 ◽

Vol 107 (1) ◽

pp. 243-250 ◽

Cited By ~ 13

Author(s):

Chenyu Chu ◽

Shimin Wei ◽

Yuanjing Wang ◽

Yufei Wang ◽

Yi Man ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Bone Regeneration ◽

Recent Progress ◽

Extracellular Vesicle

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Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities

Scientific Reports ◽

10.1038/srep45622 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 46

Author(s):

Hui Xie ◽

Zhenxing Wang ◽

Liming Zhang ◽

Qian Lei ◽

Aiqi Zhao ◽

...

Keyword(s):

Bone Regeneration ◽

Bone Matrix ◽

Extracellular Vesicle ◽

Decalcified Bone Matrix

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Faculty Opinions recommendation of Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727471342.793570774 ◽

2020 ◽

Author(s):

Warren Grayson

Keyword(s):

Bone Regeneration ◽

Bone Matrix ◽

Extracellular Vesicle ◽

Decalcified Bone Matrix

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Decellularized bone extracellular matrix in skeletal tissue engineering

Biochemical Society Transactions ◽

10.1042/bst20190079 ◽

2020 ◽

Vol 48 (3) ◽

pp. 755-764

Author(s):

Benjamin B. Rothrauff ◽

Rocky S. Tuan

Keyword(s):

Tissue Engineering ◽

Bone Regeneration ◽

Tissue Regeneration ◽

Animal Studies ◽

Tumor Resection ◽

Regenerative Capacity ◽

Skeletal Tissue ◽

Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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